Figure S5 from BBT-176, a Novel Fourth-Generation Tyrosine Kinase Inhibitor for Osimertinib-Resistant EGFR Mutations in Non–Small Cell Lung Cancer [PDF]
, 2023 Sun Min Lim +9 more
openalex +1 more source
Advanced Science, EarlyView.A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo +10 more
wiley +1 more source
circ-EGFR is a predictor of response to Cetuximab and a potential target in colorectal cancer [PDF]
Silei Sui +3 more
openalex +1 more source
Inhibition of Tumor Lipogenesis and Growth by Peptide‐Based Targeting of SREBP Activation
Advanced Science, EarlyView.A peptide that replicates the amino acid sequence in Insig1/2 loop 1 inhibits the IGF1‐induced interaction between PCK1 and Insig1/2, PCK1‐mediated phosphorylation of Insig1/2, and SREBP activity‐dependent lipid synthesis. Administration of the LNP‐Insig1/2 loop 1 peptide effectively attenuates tumor growth and sensitizes tumors to the antitumor effect
Shudi Luo +10 more
wiley +1 more source
The epidermal growth factor receptor regulates YAP signalling and promotes diabetic retinal fibrosis by modulating the degradation of SAV1. [PDF]
J Transl MedZhang W, Zhang X, Chen K, Wang Y.
europepmc +1 more source
Classification of patients at risk for chronic kidney disease by use of eGFR and albuminuria
, 2015 Jelena P. Seferović
openalex +2 more sources
AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer.
New England Journal of Medicine, 2015 P. Jänne +18 more
semanticscholar +1 more source
Advanced Science, EarlyView.Repurposing cardiac glycosides (CGs) significantly strengthens the efficacy of anti‐CD47 antibody for lung cancer treatment by boosting macrophage phagocytosis. This novel combination blocks the “don't eat me” signal and increases dual “eat‐me” signals, Fc‐FcγR and cell surface expression of calreticulin (ecto‐CRT).
Zi‐Han Ye +9 more
wiley +1 more source
cGAS Inhibits ALDH2 to Suppress Lipid Droplet Function and Regulate MASLD Progression
Advanced Science, EarlyView.cGAS is a cytosolic DNA sensor known for innate immune defense. cGAS binds and suppresses ALDH2 are showed, limiting acetyl‐CoA production. cGAS loss activates ALDH2, promoting histone acetylation, lipogenesis, and lipid droplets accumulation. cGas‐/‐ mice on a high‐fat diet show signs of worsened MASLD.
Ying Wang +14 more
wiley +1 more source
Immunotherapy in EGFR-mutant non-small cell lung cancer. [PDF]
Clin Exp MedWang L, Xian X, Ke H, Wang K.
europepmc +1 more source