Results 251 to 260 of about 598,741 (306)

Population pharmacokinetics and dose–response relationships of mitoxantrone in children with acute myeloid leukaemia

British Journal of Clinical Pharmacology, EarlyView.
Background Information on mitoxantrone pharmacokinetics in children is lacking and reduced dosing regimens applied to infants are supported by limited scientific rationale. The current study characterized mitoxantrone pharmacokinetics in a childhood acute myeloid leukaemia patient population and provides a data‐informed assessment of dosing.
Andrew M. Brandon, Hinke Huisman‐Siebinga, Shelby Barnett, Paul Wetherell, Pamela Kearns, Brenda Gibson, Nicholas Heaney, Owen Smith, André Baruchel, Arnaud Petit, Andrew Moore, Kayode Ogungbenro, Alwin D. R. Huitema, Gareth J. Veal   +13 more
wiley   +1 more source

Integrated analysis of therapeutic strategies and prognostic factors in advanced lung adenocarcinoma: Retrospective study with emphasis on gene assays, multimodality treatment approaches and predictive machine learning models. [PDF]

Oncol Lett
You S, Chen SW, Chen I, Chen WT.
europepmc   +1 more source

Pharmacokinetics of dolutegravir, tenofovir and lamivudine during venous–venous extracorporeal membrane oxygenation (VV‐ECMO): A case report

British Journal of Clinical Pharmacology, EarlyView.
While providing potentially life‐saving cardiorespiratory support for critically ill patients, extracorporeal membrane oxygenation (ECMO) may detrimentally affect pharmacokinetic (PK) performance and concurrent drug efficacy and safety. We describe a patient with Pneumocystis jirovecii pneumonia (PJP) in the context of acquired immunodeficiency ...
Tom C. Zwart, Emiel Leegwater, Thomas H. Ottens, Emile F. Schippers, Erik B. Wilms, David M. Burger, Cees van Nieuwkoop, Liesbeth B. E. Bosma   +7 more
wiley   +1 more source

IL‑37/IL‑1R8 blocks keratinocyte acantholysis via suppressing ADAM17/EGFR. [PDF]

Int J Mol Med
Hu F, Chen W, Wang Q, Zhang X, Xiao F, Zhang J, Liang J.   +6 more
europepmc   +1 more source

Tacrolimus exposure during pregnancy in kidney and liver transplantation recipients: A comparison between whole blood and plasma concentration‐to‐dose ratios

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tacrolimus monitoring is generally performed in whole blood (WB). Most (>85%) of circulating tacrolimus is bound to red blood cells. During pregnancy, WB monitoring might be suboptimal because of physiological changes including increased plasma volume and decreased haematocrit.
Jildau R. Meinderts, Paola Mian, Frederike G. I. van Vilsteren, Karien M. H. van de Wetering, Jelmer R. Prins, Stefan P. Berger, Daan J. Touw, Margriet F. C. de Jong   +7 more
wiley   +1 more source

Analysis of EGFR signaling pathway; miRNAs and inflammatory biomarkers in a high-risk oral cancer population in Pakistan - An exploratory study. [PDF]

PLoS One
Anwar N, Pervez S, Moatter T, Stark M, Chundriger Q, Ali TS, Awan S, Antonsson A.   +7 more
europepmc   +1 more source

Targeting tumor suppressor gene co-mutations in EGFR-mutant nonsmall cell lung cancer: How ACROSS2 sharpens the case for early intensification. [PDF]

CA Cancer J Clin
Gunturu KS, Khan H, de Lima Lopes G.
europepmc   +1 more source

Prediction of estimated glomerular filtration rate slope and kidney prognosis of patients with chronic kidney disease. [PDF]

Sci Rep
Nagasu H, Nakashima T, Ihara K, Fujimori R, Goto T, Nitta D, Kishi S, Sasaki T, Kashihara N.   +8 more
europepmc   +1 more source

Germ-line exon 21 EGFR V831H mutation in advanced NSCLC resistance to almonertinib: a case report. [PDF]

Front Oncol
Cai D, Lou J, Zhu Y, Wang Y.
europepmc   +1 more source