Results 31 to 40 of about 478,784 (306)

Simulation of the regulation of EGFR endocytosis and EGFR‐ERK signaling by endophilin‐mediated RhoA‐EGFR crosstalk [PDF]

FEBS Letters, 2008
Deregulations of EGFR endocytosis in EGFR‐ERK signaling are known to cause cancers and developmental disorders. Mutations that impaired c‐Cbl–EGFR association delay EGFR endocytosis and produce higher mitogenic signals in lung cancer. ROCK, an effector of small GTPase RhoA was shown to negatively regulate EGFR endocytosis via endophilin A1.
Ung, C.Y., Li, H., Ma, X.H., Jia, J., Li, B.W., Low, B.C., Chen, Y.Z.   +6 more
openaire   +2 more sources

Discovery of a novel EGFR ligand DPBA that degrades EGFR and suppresses EGFR-positive NSCLC growth [PDF]

Signal Transduction and Targeted Therapy, 2020
AbstractEpidermal growth factor receptor (EGFR) activation plays a pivotal role in EGFR-driven non-small cell lung cancer (NSCLC) and is considered as a key target of molecular targeted therapy. EGFR tyrosine kinase inhibitors (TKIs) have been canonically used in NSCLC treatment.
Nan Yao, Chen-Ran Wang, Ming-Qun Liu, Ying-Jie Li, Wei-Min Chen, Zheng-Qiu Li, Qi Qi, Jin-Jian Lu, Chun-Lin Fan, Min-Feng Chen, Ming Qi, Xiao-Bo Li, Jian Hong, Dong-Mei Zhang, Wen-Cai Ye   +14 more
openaire   +2 more sources

Incomplete reversibility of eGFR following tenofovir exposure [PDF]

, 2014
Background. Tenofovir disoproxil fumarate (TDF) has been linked to renal impairment but the extent to which this impairment is reversible is unclear. We aimed to investigate the reversibility of renal decline on TDF.Methods.
Lisa Hamzah, Richard Gilson, Lucy J. Campbell, John Walsh, Jones, R, Chadwick, D, Frank A. Post, Post, FA, Leen, Clifford, Sophie Jose, Hill, Teresa, Campbell, Lucy J, Jose, Sophie, Campbell, Lucy J., Nitsch, D, Sabin, Caroline, Sabin, Caroline A, Dorothea Nitsch, Rachael Jones, UK Collaborative HIV Cohort Study Steering Committee, Campbell, LJ, Hay, Phillip, Johnson, M, Martin Fisher, Sabin, Caroline A., Gilson, Richard, Fisher, M, ?, ?, Johnson, Margaret, Post, Frank A, Gilson, R, Hay, P, Post, Frank A., Caroline A. Sabin, Phillip Hay, Nelson, Mark, Teresa Hill, Hamzah, L, Mark Nelson, Fisher, Martin, Walsh, J, Hill, T, Chadwick, David, Hamzah, Lisa, Margaret Johnson, David Chadwick, Sabin, CA, Walsh, John, Nelson, M, Jones, Rachael, Clifford Leen, Campbell, Lucy, Post, Frank, Jose, S, Nitsch, Dorothea, Leen, C   +55 more
core   +1 more source

Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR [PDF]

Oncogene, 2012
Epidermal growth factor receptor (EGFR)-mediated cell signaling is critical for mammary epithelial cell growth and survival; however, targeting EGFR has shown no or only minimal therapeutic benefit in patients with breast cancer. Here, we report a novel regulatory mechanism of EGFR signaling that may explain the low response rates. We found that breast
Li, X, Lu, Y, Liang, K, Hsu, J -M., Albarracin, C, Mills, G B, Hung, M-C, Fan, Z   +7 more
openaire   +2 more sources

Epidermal growth factor receptor-mutated non-small-cell lung cancer: A primer on contemporary management

Cancer Research, Statistics, and Treatment, 2019
Non-small-cell lung cancer (NSCLC) constitutes 85% of patients diagnosed with lung cancer. In metastatic cases, its treatment classically consists of systemic cytotoxic chemotherapy, which resulted in a median overall survival of 7.9 months.
Akhil Rajendra, Vanita Noronha, Amit Joshi, Vijay Maruti Patil, Nandini Menon, Kumar Prabhash   +5 more
doaj   +1 more source

Study of EGFR expression in tumor tissue in patients with locally advanced oral cavity cancer receiving cetuximab therapy

Медицинский совет, 2020
Introduction: Squamous cell carcinoma of the oral cavity is one of the most common head and neck cancers with an aggressive course and high mortality rates.
A. A. Lyanova, L. Yu. Vladimirova, E. P. Ulianova, A. E. Storozhakova, N. A. Abramova, I. L. Popova, M. A. Teplyakova, N. M. Tikhanovskaya, V. S. Myagkova, K. A. Novoselova, L. A. Ryadinskaya, L. K. Strakhova, E. A. Kalabanova   +12 more
doaj   +1 more source

Osimertinib – effective treatment of NSCLC with activating EGFR mutations after progression on EGFR tyrosine kinase inhibitors [PDF]

, 2017
Non-small cell lung cancer (NSCLC) driven by activating mutations in epidermal growth factor receptor (EGFR) constitutes up to 10% of NSCLC cases. According to the NCCN recommendations, all patients (with the exception of smoking patients with squamous ...
Marcin Skrzypski, Amelia Szymanowska-Narloch, Rafał Dziadziuszko   +2 more
core   +1 more source

Interaction of GHK Tripeptide with Receptors Targeted in Some Cancer Studies: A Theoretical Approach with Molecular Docking

Hittite Journal of Science and Engineering, 2023
Cancer, defined as the uncontrolled growth and proliferation of cells, is a serious disease seen in many people around the world. For this reason, a lot of work has been done and continues to be done by scientists for the diagnosis and treatment of ...
Serda Kecel Gunduz, Bilge Bıçak
doaj   +1 more source

Optimized EGFR Blockade Strategies in EGFR Addicted Gastroesophageal Adenocarcinomas [PDF]

Clinical Cancer Research, 2021
Abstract Purpose: Gastric and gastroesophageal adenocarcinomas represent the third leading cause of cancer mortality worldwide. Despite significant therapeutic improvement, the outcome of patients with advanced gastroesophageal adenocarcinoma is poor. Randomized clinical trials failed to show a
Simona Corso, Filippo Pietrantonio, Maria Apicella, Cristina Migliore, Daniela Conticelli, Annalisa Petrelli, Laura D'Errico, Stefania Durando, Daniel Moya-Rull, Sara E. Bellomo, Stefano Ughetto, Maurizio Degiuli, Rossella Reddavid, Uberto Fumagalli, Stefano De Pascale, Giovanni Sgroi, Emanuele Rausa, Gian Luca Baiocchi, Sarah Molfino, Giovanni De Manzoni, Maria Bencivenga, Salvatore Siena, Andrea Sartore-Bianchi, Federica Morano, Salvatore Corallo, Michele Prisciandaro, Maria Di Bartolomeo, Annunziata Gloghini, Silvia Marsoni, Antonino Sottile, Anna Sapino, Caterina Marchiò, Asa Dahle-Smith, Zosia Miedzybrodzka, Jessica Lee, Siraj M. Ali, Jeffrey S. Ross, Brian M. Alexander, Vincent A. Miller, Russell Petty, Alexa B. Schrock, Silvia Giordano   +41 more
openaire   +4 more sources

Hydroxygenkwanin Suppresses Non-Small Cell Lung Cancer Progression by Enhancing EGFR Degradation

Molecules, 2020
Epidermal growth factor receptor (EGFR) is frequently overexpressed and mutated in non-small cell lung cancer (NSCLC), which is the major type of lung cancer.
Yann-Lii Leu, Tong-Hong Wang, Chih-Ching Wu, Kuo-Yen Huang, Yu-Wen Jiang, Yi-Chiung Hsu, Chi-Yuan Chen   +6 more
doaj   +1 more source