Results 31 to 40 of about 11,186 (252)

Changes in the virulence ofMycobacterium aviumafter passage through embryonated hens’ eggs [PDF]

FEMS Microbiology Letters, 2000
Eight-day-old embryonated hen's eggs were used as a model to study Mycobacterium avium virulence. Strains isolated from human patients caused 20-90% mortality when eggs were infected by injection of bacterial suspensions into the amniotic sac. Virulence of examined strains subsequently decreased with passage through eggs to between 0 and 40% mortality ...
E G, Long, E P, Ewing, J H, Bartlett, C R, Horsburgh, K A, Birkness, M A, Yakrus, G W, Newman, F D, Quinn   +7 more
openaire   +3 more sources

MDCK-Adaptive Mutation of A169S Changes Glycosylation Pattern of Hemagglutinin and Enhances MDCK-Based H7N9 Vaccine Virus Production without Loss of Antigenicity and Immunogenicity

Vaccines
The adaptation of egg-derived H7N9 candidate vaccine virus (CVV) in the mammalian cell line is an approach to developing a high-growth virus strain for the mass production of vaccine manufacturing.
Po-Ling Chen, Tsai-Chuan Weng, Chia-Chun Lai, Tsai-Teng Tzeng, Min-Han Lin, Kai-Chieh Hu, Alan Yung-Chih Hu, Min-Shi Lee, Wang-Chou Sung   +8 more
doaj   +1 more source

Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytes. [PDF]

, 1987
Legionella pneumophila, the causative agent of Legionnaires' disease, is a Gram-negative bacterium and a facultative intracellular parasite that multiplies in human monocytes and alveolar macrophages. In this paper, mutants of L.
Horwitz, MA
core  

Quantitative Mass Spectrometry‐Based Biodistribution of Monoclonal Antibodies: An Alternative to Radio‐Biodistribution

Advanced Science, EarlyView.
Monoclonal antibodies are powerful anticancer therapeutics targeting tumor‐associated antigens. Mass spectrometry enables precise and accurate quantification of mAbs in tumor plasma and healthy organs. Unlike ligand binding assay and radioactivity, mass spectrometry does not suffer from matrix effects and labelling artefacts while facilitating method ...
Domenico Ravazza, Sheila Dakhel Plaza, Samuele Cazzamalli, Andrea Ciamarone, Andrea Galbiati, Riccardo Stucchi, Frederik Peissert, Emanuele Puca, Dario Neri, Ettore Gilardoni   +9 more
wiley   +1 more source

Pathogenic, Molecular, and Immunological Properties of a Virus Associated with Sea Turtle Fibropapillomatosis. Phase II : Viral Pathogenesis and Development of Diagnostic Assays [PDF]

, 2000
Research conducted under this RWO from July 1, 1997 through June 30, 2000 has provided important new information about the pathogenesis, virology, and immunology of marine turtle fibropapillomatosis. In particular, we have provided strong evidence for
Bjorndal, Karen A., Bolten, Alan, Brown, Daniel R., Coberley, Sadie, Ehrhart, Llewellyn, Herbst, Lawrence H., Klein, Paul A., Lackovich, Joel K., Moretti, Ritchie H.   +8 more
core  

Failure to infect laboratory rodent hosts with human isolates of Rodentolepis(= Hymenolepis) nana [PDF]

, 2002
Confusion exists over the species status and host-specificity of the tapeworm Rodentolepis (= Hymenolepis) nana. It has been described as one species, R. nana, found in both humans and rodents. Others have identified a subspecies; R. nana var.
Andreassen, Arme, Baer, Baily, Czaplinski, Ito, J.M. Behnke, Kennedy, Lloyd, M.G. Macnish, Maki, Meloni, Pawlowski, R.C.A. Thompson, Ronald, Smyth, Spasskii, Tena, U.M. Morgan, Voge, Yamaguti   +20 more
core   +3 more sources

Passage of Testosterone-4-C14 from the Egg Shell to the Albumin

Poultry Science, 1971
Abstract A variety of substances may be introduced into the egg by immersing 2-4 cm. of the pointed end into prepared solutions (Seltzer, 1956). We have inhibited or eliminated the development of the bursa of Fabricius by dipping the egg into varying concentrations of testosterone propionate (Glick, 1964). We have attempted to determine the amount of
J A, Wilson, N, Mitlin, B, Glick
openaire   +2 more sources

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

Advanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang, Weiyong Song, Heng Yin, Yi Wang, Yi Zou, Yuling Li, Yue Luo, Chao Xiang, Xiaoqin Liu, Yan Xiong, Yong Wang, Ke Jiang   +11 more
wiley   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Function of Bmpr1a in ES cell differentiation and cell competition [PDF]

, 2010
Bone morphogenetic protein (BMP) 4 signalling via BMPR1A is required for the maintenance of the epiblast in the early embryo, and for self-renewal of pluripotent mouse embryonic stem (ES) cells by inhibiting neural differentiation.
Sancho, Maria Margarida Gouveia, Sancho, Maria Margarida Gouveia   +1 more
core   +1 more source