Results 81 to 90 of about 660,894 (299)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Binary black hole spectroscopy

, 2007
We study parameter estimation with post-Newtonian (PN) gravitational waveforms for the quasi-circular, adiabatic inspiral of spinning binary compact objects. The performance of amplitude-corrected waveforms is compared with that of the more commonly used
, Anand S Sengupta, Arun K G, Arun K G, Arun K G, Babak S, Babak S Cokelaer T Sathyaprakash B S Sengupta A S, Berti E, Blanchet L, Blanchet L, Chris Van Den Broeck, Dhurandhar S V, Dhurandhar S V, Dreyer O, Grishchuk L P, Gürsel Y Tinto M Ashby N, Hellings R W, Helstrom C W, Itoh Y, Kokkotas K D, Mielke E W Schunck F E Piran T, Punturo M, Röver C Meyer R Christensen N, Sintes A M Vecchio A Dumarchez J, Sintes A M Vecchio A Meshkov S, Thorne K S, Van Den Broeck C, Van Den Broeck C   +27 more
core   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Filhos da mãe - Animus da mãe na vida do filho

Self, 2019
Este artigo tem por objetivo refletir sobre as pessoas nascidas no contexto da ausência paterna, os “filhos da mãe”. A partir do entendimento do inestimável valor do fenômeno relacional humano e do funcionamento psíquico, este trabalho aplica os ...
Irene Pereira Gaeta
doaj   +1 more source

Egomunities, Exploring Socially Cohesive Person-based Communities [PDF]

, 2011
In the last few years, there has been a great interest in detecting overlapping communities in complex networks, which is understood as dense groups of nodes featuring a low outbound density.
Chelius, Guillaume, Fleury, Eric, Friggeri, Adrien   +2 more
core   +4 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Subjetividad y reflexión en las lecciones tempranas de Friburgo (1919-1923) de Martin Heidegger

Pensamiento. Revista de Investigación e Información Filosófica
En el presente trabajo nos proponemos trazar la distinción entre la subjetividad preteórica y el sujeto cognoscente en las lecciones tempranas de Friburgo de Martin Heidegger desde el punto de vista de la función metodológica y el carácter ontológico de ...
Danila Suárez Tomé
doaj   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

La filosofia di Descartes è una filosofia del soggetto?

Lexicon Philosophicum
Il presente articolo mira a chiarire l’uso e il significato della nozione cartesiana di soggetto, domandando anzitutto la legittimità del suo impiego in relazione alla filosofia di Descartes, muovendo dalle critiche che tradizionalmente le sono state ...
Alberto De Vita
doaj   +1 more source