Results 61 to 70 of about 7,056 (256)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Ego-Vehicle Speed Correction for Automotive Radar Systems Using Convolutional Neural Networks

Sensors
The development of autonomous driving vehicles has increased the global demand for robust and efficient automotive radar systems. This study proposes an automotive radar-based ego-vehicle speed detection network (AVSD Net) model using convolutional ...
Sunghoon Moon, Daehyun Kim, Younglok Kim
doaj   +1 more source

N ETWORK C ARDS AS A W AY OF D ISCOVERING THE R EFLECTIVE T HINKING OF T EACHER T RAINEES: THE R ELEVANCIES OF A Q UALITATIVE A NALYSIS [PDF]

PedActa, 2018
In this paper we are going to analyse the reflections of teacher trainees about teaching activities with th e help of ego - centred networks. The primary goal was to connect reflective thinking and the topics of ego - centred networks in a ...
Sántha, Kálmán
doaj  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Persistent Homology Combined with Machine Learning for Social Network Activity Analysis

Entropy
Currently, the rapid development of social media enables people to communicate more and more frequently in the network. Classifying user activities in social networks helps to better understand user behavior in social networks.
Zhijian Zhang, Yuqing Sun, Yayun Liu, Lin Jiang, Zhengmi Li   +4 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Effect of genetype on anxiety and nociceptive sensitivity: An ego network analysis approach

Molecular Pain, 2017
Purpose The aim of this study was to predict key genes and their relationships for anxiety and nociceptive sensitivity related to Comt1 genetype. Methods The raw data of E-GEOD-20160 related to anxiety and nociceptive sensitivity were obtained.
Wenzheng Li, Shoutao Zhao, Zhenhong Zhang   +2 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Bot Detection on Social Networks Using Persistent Homology

Mathematical and Computational Applications, 2020
The growth of social media in recent years has contributed to an ever-increasing network of user data in every aspect of life. This volume of generated data is becoming a vital asset for the growth of companies and organizations as a powerful tool to ...
Minh Nguyen, Mehmet Aktas, Esra Akbas
doaj   +1 more source