Results 41 to 50 of about 327 (91)

Human activities link fruit bat presence to Ebola virus disease outbreaks

Mammal Review, Volume 50, Issue 1, Page 1-10, January 2020., 2020
Forest loss and fragmentation and outbreaks of Ebola virus disease (EVD) in humans are linked. Deforestation may alter the natural circulation of viruses and change the composition, abundance, behaviour and possibly viral exposure of reservoir species. This in turn might increase contact between infected animals and humans.
Jesús Olivero, Julia E. Fa, Miguel Á. Farfán, Ana L. Márquez, Raimundo Real, F. Javier Juste, Siv A. Leendertz, Robert Nasi   +7 more
wiley   +1 more source

Natural reservoir Rousettus aegyptiacus bat host model of orthonairovirus infection identifies potential zoonotic spillover mechanisms

Scientific Reports, 2022
The human-pathogenic Kasokero virus (KASV; genus Orthonairovirus) has been isolated from the sera of Egyptian rousette bats (ERBs; Rousettus aegyptiacus) captured in Uganda and unengorged Ornithodoros (Reticulinasus) faini ticks collected from the rock ...
Amy J. Schuh, Brian R. Amman, Jonathan C. Guito, James C. Graziano, Tara K. Sealy, Shannon G. M. Kirejczyk, Jonathan S. Towner   +6 more
doaj   +1 more source

Histopathologic and Immunohistochemical Evaluation of Induced Lesions, Tissue Tropism and Host Responses following Experimental Infection of Egyptian Rousette Bats (Rousettus aegyptiacus) with the Zoonotic Paramyxovirus, Sosuga Virus

Viruses, 2022
Ecological and experimental infection studies have identified Egyptian rousette bats (ERBs; Rousettus aegyptiacus: family Pteropodidae) as a reservoir host for the zoonotic rubula-like paramyxovirus Sosuga virus (SOSV). A serial sacrifice study of colony-
Shannon G. M. Kirejczyk, Brian R. Amman, Amy J. Schuh, Tara K. Sealy, César G. Albariño, Jian Zhang, Corrie C. Brown, Jonathan S. Towner   +7 more
doaj   +1 more source

Development of a reverse genetics system for Sosuga virus allows rapid screening of antiviral compounds. [PDF]

PLoS Neglected Tropical Diseases, 2018
Sosuga virus (SOSV) is a recently discovered zoonotic paramyxovirus isolated from a single human case in 2012; it has been ecologically and epidemiologically associated with transmission by the Egyptian rousette bat (Rousettus aegyptiacus).
Stephen R Welch, Ayan K Chakrabarti, Lisa Wiggleton Guerrero, Harley M Jenks, Michael K Lo, Stuart T Nichol, Christina F Spiropoulou, César G Albariño   +7 more
doaj   +1 more source

Paramyxo- and Coronaviruses in Rwandan Bats

Tropical Medicine and Infectious Disease, 2019
A high diversity of corona- and paramyxoviruses have been detected in different bat species at study sites worldwide, including Africa, however no biosurveillance studies from Rwanda have been reported.
Wanda Markotter, Marike Geldenhuys, Petrus Jansen van Vuren, Alan Kemp, Marinda Mortlock, Antoine Mudakikwa, Louis Nel, Julius Nziza, Janusz Paweska, Jacqueline Weyer   +9 more
doaj   +1 more source

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): Ebola virus disease

EFSA Journal, Volume 15, Issue 7, July 2017., 2017
Abstract Ebola virus disease has been assessed according to the criteria of the Animal Health Law (AHL), in particular criteria of Article 7 on disease profile and impacts, Article 5 on the eligibility of Ebola virus disease to be listed, Article 9 for the categorisation of Ebola virus disease according to disease prevention and control rules as in ...
EFSA Panel on Animal Health and Welfare (AHAW), Simon More, Anette Bøtner, Andrew Butterworth, Paolo Calistri, Klaus Depner, Sandra Edwards, Bruno Garin‐Bastuji, Margaret Good, Christian Gortázar Schmidt, Virginie Michel, Miguel Angel Miranda, Søren Saxmose Nielsen, Mohan Raj, Liisa Sihvonen, Hans Spoolder, Jan Arend Stegeman, Hans‐Hermann Thulke, Antonio Velarde, Preben Willeberg, Christoph Winckler, Francesca Baldinelli, Alessandro Broglia, Beatriz Beltrán Beck, Lisa Kohnle, Joana Morgado, Dominique Bicout   +26 more
wiley   +1 more source

Interferon Alpha Characterization and Its Comparative Expression in PBM Cells of Capra hircus and Antelope cervicapra Cultured in the Presence of TLR9 Agonist

Molecular Biology International, Volume 2010, Issue 1, 2010., 2010
TLR9 plays pivotal role in innate immune responses through upregulation of costimulatory molecules and induction of proinflammatory cytokines like type I interferons including interferon alpha (IFNA). The present study characterized IFNA cDNA and predicted protein sequences in goat and black buck. Response of the PBM cells to TLR9 agonist CpG ODN C and
Ramesh Doreswamy, Mohini Saini, Devendra Swarup, Vivek Kumar Singh, Suchitra Upreti, Asit Das, Praveen K. Gupta, Yogesh C. Awasthi   +7 more
wiley   +1 more source

Species-specific gene programs define divergent antiviral responses in Marburg virus reservoir bats and humans

Cell Reports
Summary: Bats tolerate viruses that cause severe disease in humans. Egyptian rousette bats, the natural reservoirs of Marburg virus (MARV), sustain asymptomatic infection, whereas humans develop severe and fatal disease.
André Filipe Pastor, Shruti Shirsathe, Santiago Vidal-Freire, Natalia M. Ferressini-Gerpe, Jonathan Guito, Rachel Somavarapu, Juan Angel Patiño-Galindo, Elaina Giannetti, Maya Tagliavia, Heng Pan, Gabriella Worwa, Adolfo García-Sastre, Jonathan S. Towner, Jeffrey R. Johnson, Jens H. Kuhn, Mariano Sanchez-Lockhart, Gustavo Palacios   +16 more
doaj   +1 more source

Where Do Core Thalamocortical Axons Terminate in Mammalian Neocortex When There Is No Cytoarchitecturally Distinct Layer 4?

Journal of Comparative Neurology, Volume 532, Issue 7, July 2024.
Immunohistochemical staining for vesicular glutamate transporter 2 reveals the “core” thalamocortical projection to the neocortex in the African elephant. In the elephant and other mammals with unusual skin (such as pachydermatous skin), layer 4 is cytoarchitecturally indistinct, possibly absent, and the thalamocortical input terminates primarily on ...
Adhil Bhagwandin, Zoltán Molnár, Mads F. Bertelsen, Karl Æ. Karlsson, Abdulaziz N. Alagaili, Nigel C. Bennett, Patrick R. Hof, Consolate Kaswera‐Kyamakya, Emmanuel Gilissen, Jaikishan Jayakumar, Paul R. Manger   +10 more
wiley   +1 more source

Establishment of immortalized Egyptian Rousettus bat cell lines

FEBS Open Bio, Volume 14, Issue 4, Page 598-612, April 2024.
Egyptian Rousettus bats serve as a reservoir for pathogens. Fibroblast cell lines K4DT and SV40 were established to overcome the limited cell division of primary bat cells. While three K4DT and one SV40 cell lines were virtually immortalized with normal karyotypes, two SV40 lines had aberrant karyotypes.
Lanlan Bai, Tetsuya Tani, Takeshi Kobayashi, Ryotaro Nouda, Yuta Kanai, Yusuke Sano, Kazutoshi Takami, Hiroshi Tomita, Eriko Sugano, Taku Ozaki, Tohru Kiyono, Tomokazu Fukuda   +11 more
wiley   +1 more source