Results 31 to 40 of about 85,247 (140)

The Trimeric Artesunate Analog TF27, a Broadly Acting Anti-Infective Model Drug, Exerts Pronounced Anti-SARS-CoV-2 Activity Spanning Variants and Host Cell Types

Pharmaceutics, 2022
Starting in 2019, the spread of respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated pandemic of the corona virus disease (COVID-19) has led to enormous efforts in the development of medical countermeasures.
Friedrich Hahn, Christina Wangen, Sigrun Häge, Lars Herrmann, Alexandra Herrmann, Svetlana B. Tsogoeva, Manfred Marschall   +6 more
doaj   +1 more source

Molnupiravir: A new candidate for COVID‐19 treatment

Pharmacology Research &Perspectives, Volume 10, Issue 1, February 2022., 2022
Molnupiravir in COVID‐19. Abstract The novel coronavirus disease 2019 (COVID‐19) emerged in late December 2019 in china and has rapidly spread to many countries around the world. The effective pharmacotherapy can reduce the mortality of COVID‐19. Antiviral medications are the candidate therapies for the management of COVID‐19.
Fariba Pourkarim, Samira Pourtaghi‐Anvarian, Haleh Rezaee   +2 more
wiley   +1 more source

The recent outbreaks of human coronaviruses: A medicinal chemistry perspective

Medicinal Research Reviews, Volume 41, Issue 1, Page 72-135, January 2021., 2021
Abstract Coronaviruses (CoVs) infect both humans and animals. In humans, CoVs can cause respiratory, kidney, heart, brain, and intestinal infections that can range from mild to lethal. Since the start of the 21st century, three β‐coronaviruses have crossed the species barrier to infect humans: severe‐acute respiratory syndrome (SARS)‐CoV‐1, Middle East
Thanigaimalai Pillaiyar, Lukas L. Wendt, Manoj Manickam, Maheswaran Easwaran   +3 more
wiley   +1 more source

Synthesis of a finite two-terminal network whose driving-point impedance is a prescribed function of frequency

, 1931
Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept.
O. Brune
semanticscholar   +1 more source

Solution of the problem of Plateau

, 1931
ion being made, in case the representation g is improper of the first kind, of the values of 0, at most denumerably infinite in number, where gi(0) is discontinuous.
J. Douglas
semanticscholar   +1 more source

Tropical Forests of the Caribbean

Nature, 1931
THE Spaniard Cortez is known as a brave man, with an indomitable spirit and an almost inhuman quality of endurance. The American Tom Gill, more than four hundred years later, in adventuring the survey of the tropical forests of the Caribbean, required a ...
T. Gill
semanticscholar   +1 more source

Tautomerism‐Governed Two‐Proton‐Coupled Electron Transfer in the Oxidation of a Molnupiravir by Electrogenerated Superoxide Radical Anion in N,N‐Dimethylformamide

ChemistrySelect, Volume 11, Issue 21, 4 June 2026.
Tautomerization‐assisted oxidation of molnupiravir by superoxide (O2•−) in aprotic DMF. The thermodynamically favored oxime tautomer of the N4‐hydroxycytosine moiety forms a prereactive complex (PRC) with O2•− through hydrogen‐bonding interactions.
Tatsushi Nakayama, Kaisei Hara
wiley   +1 more source

Boesenbergia rotunda–Derived Phytochemicals as Potent Inhibitors of SARS‐CoV‐2 Papain–Like Protease (PLpro): Insights From Molecular Docking and Dynamic Simulation

Scientifica, Volume 2026, Issue 1, 2026.
The papain‐like protease (PLpro) of SARS‐CoV‐2 plays fundamental roles in its replication, and its mechanistic inhibition can impede the virus’s replication and infection. Most Plpro inhibitors identified thus far are chemically synthesized and subject to numerous restrictions regarding stability and adverse side effects.
Dhrubo Ahmed Khan, Mohammad Ashik Sheikh, Raihan Rahman Imon, Md. Imtiaz, Shamin Ahmed, Harasit Gharami, Ryan V. Labana, Tajudeen O. Jimoh, Anand Gaurav, Maria L. Pereira, Muhammad Nawaz, Julieta Z. Dungca, Md. Nazmul Hasan, Manik Ghosh, Veeranoot Nissapatorn, Nidhi Chaudhary   +15 more
wiley   +1 more source

A Pyrido‐Quinoxaline Derivative That Downregulates Reticulon 3 Protein Exhibits Potent Antiviral Activity Against Zika Virus

Journal of Medical Virology, Volume 97, Issue 9, September 2025.
ABSTRACT In the wake of the COVID‐19 pandemic, awareness of emerging pathogens has significantly increased, prompting greater investment in research and preparedness. In this context, arboviral diseases are recognized as unmet medical challenges due to their rapid spread. Notably, the geographical range of several flaviviral diseases is expanding: Zika
Erika Plicanti, Andrea Deiana, Silvia Nottoli, Giulia Lottini, Roberta Ibba, Sandra Piras, Carlo Di Marzo, Silvia Vegni, Michele Lai, Mauro Pistello, Antonio Carta, Giulia Freer   +11 more
wiley   +1 more source

On the composite nature of certain potato virus diseases of the mosaic group as revealed by the use of plant indicators.

, 1931
In 1928 some experiments by the writer (1929) on the transmission of a potato mosaic virus to tobacco revealed the curious fact that needle and aphis ( Myzus persicae ) inoculation respectively, from the same mosaic-affected potato plant, produced in ...
K. M. Smith
semanticscholar   +1 more source