Results 41 to 50 of about 85,247 (140)

In Vitro Synergistic Antiviral Effects of β‐D‐N4‐hydroxycytidine and Teriflunomide in Combination against a Broad Range of RNA Viruses

Journal of Medical Virology, Volume 97, Issue 7, July 2025.
ABSTRACT Emerging and important endemic viral diseases without effective antiviral are important public health threat. An effective broad‐spectrum antiviral can be a pivotal tool to mitigate future epidemics and provide a solution for endemic viral diseases. Molnupiravir, a pyrimidine analog, is known for the COVID‐19 treatment.
Thanyaporn Sirihongthong, Kunlakanya Jitobaom, Chompunuch Boonarkart, Songkran Thongon, Prasert Auewarakul   +4 more
wiley   +1 more source

Myricetin‐bound crystal structure of the SARS‐CoV‐2 helicase NSP13 facilitates the discovery of novel natural inhibitors

Acta Crystallographica Section D, Volume 81, Issue 6, Page 310-326, June 2025.
The myricetin‐bound crystal structure of the SARS‐CoV‐2 helicase reveals a conserved allosteric binding site. Guided by these structural insights, caffeic acid derivatives identified through virtual screening were experimentally validated as novel natural inhibitors of NSP13.The SARS‐CoV‐2 helicase NSP13 is a highly conserved and essential component of
Patrick Kloskowski, Piotr Neumann, Priya Kumar, Annette Berndt, Matthias Dobbelstein, Ralf Ficner   +5 more
wiley   +1 more source

The Vascular Responses of the Eye

, 1931
The investigations described in this paper follow from the theory sponsored by one of us, that the aqueous humour is a dialysate of the blood and the vitreous body is a simple hydrophilic gel (1927, a and 1930).
P. M. Duke-elder, W. Duke-Elder
semanticscholar   +1 more source

Ecotoxicological data of selected antiviral drugs acting against SARS-CoV-2: Aliivibrio fischeri bioluminescence inhibition, Daphnia magna immobilization, and comparison with in silico predictions

Environmental Sciences Europe
Micropollutants such as pharmaceuticals that are released into the environment after wastewater treatment may have a severe impact on organisms in the aquatic environment.
Indra Bartels, Nazmun Nahar, Esther Smollich, Sonja Zimmermann, Torsten C. Schmidt, Martin Jaeger, Bernd Sures   +6 more
doaj   +1 more source

The Relation between the Pulmonary and Bronchial Vascular Systems

, 1931
Berry, Brailsford and Daly (1931) showed that perfusion of the bronchial vascular system may be carried out ( a ) by way of the posterior bronchial arteries, or ( b ) in conjunction with the thoracic parietes and oesophagus, or with the oesophagus alone,
J. L. Berry, I. D. Daly
semanticscholar   +1 more source

The Extent of Air in the Tracheoles of some Terrestrial Insects

, 1931
Recently a theory was put forward (Wigglesworth, 1930) according to which the extent of air in the tracheal of insects is determined by the osmotic pressure of the tissue fluids in which these capillaries are bathed.
V. Wigglesworth
semanticscholar   +1 more source

EIDD-2801 to EIDD-1931 Equimolar Dose Conversion: Derivation and Peer-Reviewed Basis of the 1.27 Molar Weight Ratio

This technical note provides a transparent, source-referenced derivation of the molar weight conversion factor (1.27) used to calculate equimolar doses of EIDD-1931 (N4-hydroxycytidine, NHC) from established EIDD-2801 (molnupiravir) dosing schedules. The factor is a standard stoichiometric ratio derived from the confirmed molecular weights of EIDD-2801
openaire   +2 more sources

2024 ACVIM Forum Research Abstract Program

Journal of Veterinary Internal Medicine, Volume 38, Issue 5, Page 2840-2970, September/October 2024.
wiley   +1 more source

Radioactivity and Earth Movements.

Nature, 1931
A. Holmes
semanticscholar   +1 more source

Uridine-cytidine kinase 2 potentiates the mutagenic influence of the antiviral β-d-N4-hydroxycytidine. [PDF]

Nucleic Acids Res, 2023
Xu Z, Flensburg C, Bilardi RA, Majewski IJ.   +3 more
europepmc   +1 more source