Results 91 to 100 of about 291,615 (215)

Dysregulated ribosome quality control in human diseases

The FEBS Journal, Volume 292, Issue 5, Page 936-959, March 2025.
Ensuring the synthesis of full‐length, correctly folded proteins is vital for maintaining homeostasis. If a translating ribosome stalls, the trailing ribosomes collide into it, which if left unresolved leads to deleterious effects on the cell due to the accumulation of protein aggregates.
Tom McGirr, Okan Onar, Seyed Mehdi Jafarnejad   +2 more
wiley   +1 more source

Lifespan Regulation by Evolutionarily Conserved Genes Essential for Viability [PDF]

, 2011
Evolutionarily conserved mechanisms that control aging are predicted to have prereproductive functions in order to be subject to natural selection. Genes that are essential for growth and development are highly conserved in evolution, but their role in ...
Curran, Sean Patrick, Ruvkun, Gary B.
core   +1 more source

PathVar: A Customisable NGS Variant Calling Algorithm Implicates Novel Candidate Genes and Pathways in Hemiplegic Migraine

Clinical Genetics, Volume 107, Issue 2, Page 157-168, February 2025.
PathVar, a customisable next‐generation sequencing (NGS) variant calling algorithm, has been employed to investigate genes potentially implicated in hemiplegic migraine (HM). This approach enabled the identification of several candidate genes associated with HM, including SLC38A10, AMPD1, APC2, PADI3, FRAS1, SETX, PRAG1 and GSE1.
Mohammed M. Alfayyadh, Neven Maksemous, Heidi G. Sutherland, Rodney A. Lea, Lyn R. Griffiths   +4 more
wiley   +1 more source

Influence of obesity and insulin sensitivity on insulin signaling genes in human omental and subcutaneous adipose tissues⃞

Journal of Lipid Research, 2008
Obesity and insulin resistance are independent risk factors for metabolic syndrome, diabetes, and cardiovascular disease. Adipose tissue samples from nonobese (NO), insulin-sensitive obese (ISO), and insulin-resistant obese (IRO) subjects from ...
R. MacLaren, W. Cui, S. Simard, K. Cianflone   +3 more
doaj  

Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes. [PDF]

, 2019
BackgroundMyriad challenges to the proper folding and structural maturation of secretory pathway client proteins in the endoplasmic reticulum (ER) - a condition referred to as "ER stress" - activate intracellular signaling pathways termed the unfolded ...
Colon-Negron, Kevin, Ghosh, Rajarshi, Papa, Feroz R   +2 more
core   +1 more source

The Role of Cytoplasmic mRNA Cap-Binding Protein Complexes in Trypanosoma brucei and Other Trypanosomatids. [PDF]

, 2017
Trypanosomatid protozoa are unusual eukaryotes that are well known for having unusual ways of controlling their gene expression. The lack of a refined mode of transcriptional control in these organisms is compensated by several post-transcriptional ...
Campbell, David A, de Melo Neto, Osvaldo P, Freire, Eden R, Sturm, Nancy R   +3 more
core   +2 more sources

Selection and Validation of Appropriate Reference Genes for qRT‐PCR Analysis of Iris germanica L. Under Various Abiotic Stresses

Food Science &Nutrition, Volume 13, Issue 1, January 2025.
In this research, we evaluated the expression stability of 9 candidate reference genes by four different algorithms (GeNorm, Normfinder, BestKeeper, and RefFinder). ACT and F3H appeared to be the most reliable reference genes under different abiotic stresses.
Yuan Yuan, Chungui Liu, Jianzhong Bao, Fengtong Li   +3 more
wiley   +1 more source

Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex [PDF]

, 2011
VACV gene C16L encodes a 37-kDa protein that is highly conserved in orthopoxviruses and functions as an immunomodulator. Intranasal infection of mice with a virus lacking C16L (vΔC16) induced less weight loss, fewer signs of illness and increased ...
Peters, Nicholas Edward, Peters, Nicholas Edward   +1 more
core   +1 more source

Plum pox virus: An overview of the potyvirus behind sharka, a harmful stone fruit disease

Annals of Applied Biology, Volume 186, Issue 1, Page 49-75, January 2025.
Plum pox virus is a member of the genus Potyvirus in the family Potyviridae. The significance of this virus is underscored by its large strain diversity, wide host range, broad geographical distribution and the great socio‐economic impact of sharka, the disease it causes. Abstract The study of Potyvirus plumpoxi (plum pox virus, PPV) has a long history,
Juan Antonio García, Bernardo Rodamilans, Sandra Martínez‐Turiño, Adrian A. Valli, Carmen Simón‐Mateo, Mariano Cambra   +5 more
wiley   +1 more source

Proteomic analysis across aged tissues reveals distinct signatures and the crucial involvement of midgut barrier function in the regulation of aging

Aging Cell, Volume 24, Issue 1, January 2025.
Proteomic analysis reveals that instead of specific proteins, different tissues exhibit common dysregulated functional networks. Specifically, the integrity of the midgut barrier function is compromised during aging, which can be restored through the downregulation of the insulin receptor (InR).
Congying Zhang, Jinlong Wang, Tianzhao Yao, Jiaxin Hu, Feifei Sun, Chunlu Feng, Zhendong Sun, Yuzhuo Shao, Zhu Wang, Jiarui Wu, Yunpeng Huang   +10 more
wiley   +1 more source