Results 171 to 180 of about 291,615 (215)
Frog virus 3-induced translational shut-off: activation of an eIF-2 kinase in virus-infected cells
Virus Research, 1989 Infection of susceptible fathead minnow or Friend erythroleukemia cells with either infectious or heat-inactivated frog virus 3 led to the rapid inhibition of cellular protein synthesis. As seen in other cells, translational shut-off was accompanied by the dissociation of polysomes, but not the degradation of irreversible inactivation of cellular mRNAs.
V. Gregory Chinchar, J N Dholakia
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A ribosomal protein mediates eIF-2 phosphorylation by interferon-induced kinase [PDF]
Nature, 1980 We have previously reported that treatment of mouse L cells with interferon (IFN) induces a reduction of initiation factor (eIF-2) activity (ternary complex formation of eIF-2 with Met-tRNAf and GTP)1, and that the reduction of eIF-2 activity involves the phosphorylation of eIF-2 by an IFN-induced protein kinase2.
Kenzo Ohtsuki +4 more
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Biochemistry, 1991
A highly purified preparation of heme-regulated inhibitor (HRI), an eIF-2 alpha kinase, from rabbit reticulocyte lysates has been used for generating monoclonal antibodies (mAB).
J. Pal, J. J. Chen, I. London
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A highly purified preparation of heme-regulated inhibitor (HRI), an eIF-2 alpha kinase, from rabbit reticulocyte lysates has been used for generating monoclonal antibodies (mAB).
J. Pal, J. J. Chen, I. London
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Biochemistry, 1987
Highly purified preparations of the heme-controlled eIF-2 alpha (eukaryotic peptide initiation factor 2 alpha subunit) kinase of rabbit reticulocytes contain an abundant 90-kilodalton (kDa) peptide that is immunologically cross-reactive with spectrin and
D. W. Rose +4 more
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Highly purified preparations of the heme-controlled eIF-2 alpha (eukaryotic peptide initiation factor 2 alpha subunit) kinase of rabbit reticulocytes contain an abundant 90-kilodalton (kDa) peptide that is immunologically cross-reactive with spectrin and
D. W. Rose +4 more
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Biochemistry, 1993
The heme-regulated inhibitor (HRI) of protein synthesis becomes activated in rabbit reticulocyte lysates in response to a variety of conditions including heme-deficiency, addition of oxidants, and heat shock.
R. Matts, Robin Hurst, Zuoyu Xu
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The heme-regulated inhibitor (HRI) of protein synthesis becomes activated in rabbit reticulocyte lysates in response to a variety of conditions including heme-deficiency, addition of oxidants, and heat shock.
R. Matts, Robin Hurst, Zuoyu Xu
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Virology, 1988
A series of clones has been derived from an interferon-resistant murine cell line, Ltk- aprt-, and their antiviral properties have been characterized. In the parental Ltk- aprt- line interferon is unable to establish antiviral properties or to increase the levels of 2,5-oligo(A) synthetase, the 2,5-oligo(A)-activated endonuclease F, 2',5 ...
J. Lewis
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A series of clones has been derived from an interferon-resistant murine cell line, Ltk- aprt-, and their antiviral properties have been characterized. In the parental Ltk- aprt- line interferon is unable to establish antiviral properties or to increase the levels of 2,5-oligo(A) synthetase, the 2,5-oligo(A)-activated endonuclease F, 2',5 ...
J. Lewis
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Molecular and Cellular Biochemistry, 2004
Protein kinase CK2 forms complexes with some protein substrates what may be relevant for the physiological control of this protein kinase. In previous studies in rat liver cytosol we had detected that the trimeric form of eukaryotic translation initiation factor 2 (eIF-2) co-eluted with protein kinase CK2.
M. Riera +7 more
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Protein kinase CK2 forms complexes with some protein substrates what may be relevant for the physiological control of this protein kinase. In previous studies in rat liver cytosol we had detected that the trimeric form of eukaryotic translation initiation factor 2 (eIF-2) co-eluted with protein kinase CK2.
M. Riera +7 more
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Biochemical and Biophysical Research Communications, 1988 The eukaryotic initiation factor 2 (eIF-2) from calf brain has been purified to homogeneity and free of endogenous kinase activity. Phosphorylation of eIF-2 factor has been examined with four different protein kinases. Casein kinase II, calcium/phospholipid-dependent protein kinase and cyclic AMP-dependent protein kinase from brain, phosphorylate the ...
Alberto Alcázar +3 more
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Purification of Eukaryotic Initiation Factors elF-2, eIF-2B and elF-2a Kinase from Bovine Liver
Preparative Biochemistry, 1993Eukaryotic initiation factors 2 and 2B (eIF-2; eIF-2B) are components of the rate-limiting step in the initiation of eukaryotic protein synthesis and are involved in the regulation of this process. When the alpha-subunit of eIF-2 is phosphorylated by an eIF-2 alpha kinase, the phosphorylated eIF-2 alpha (eIF-2 alpha(P)) binds tightly to eIF-2B and ...
Anne M. Karinch +3 more
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Current Biotechnology
Fungi infections are responsible for more than 1.6 million deaths per year worldwide. Treatment is time-consuming, compromising the kidney and liver functions.
C. B. Assunção +6 more
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Fungi infections are responsible for more than 1.6 million deaths per year worldwide. Treatment is time-consuming, compromising the kidney and liver functions.
C. B. Assunção +6 more
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