Results 181 to 190 of about 291,615 (215)

Isolation of a translational inhibitor from wheat germ with protein kinase activity that phosphorylates initiation factor eIF-2

Biochemical and Biophysical Research Communications, 1980
Abstract A translational inhibitor (WGI) has been partially purified from wheat germ extracts. WGI inhibits protein synthesis in rabbit reticulocyte lysates with inhibition kinetics that are similar to those observed in heme-deficiency or by the addition of purified heme-regulated translational inhibitor (HRI).
Rajinder Singh Ranu
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Phosphorylation of Wheat Germ Initiation Factor 2 (eIF-2) byN-Ethylmaleimide-Treated Wheat Germ Lysates and by Purified Casein Kinase II Does Not Affect the Guanine Nucleotide Exchange on eIF-2

Archives of Biochemistry and Biophysics, 1995
Phosphorylation of the small subunit of eukaryotic initiation factor-2 (eIF-2 alpha) impairs protein synthesis in mammalian systems. It is not known, however, if a similar regulatory mechanism exists in plants. Previous reports indicate that one of the wheat germ eIF-2 subunits, the p40-41 doublet, is phosphorylated by heterologous eIF-2 alpha kinases.
Janaki Narahari, Vattem M. Krishna, Kolluru V.A. Ramaiah   +2 more
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Activation of the double-stranded RNA-dependent eIF-2 alpha kinase by cellular RNA from 3T3-F442A cells.

European Journal of Biochemistry, 1991
The interferon induced double-stranded-RNA-dependent eIF-2 alpha kinase has an established role in mediating part of interferons anti-viral effects. Several studies have suggested that it may have additional functions in cells not infected with virus ...
J. Li, R. Petryshyn
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Regulation of the interferon-inducible eIF-2α protein kinase by small RNAs

Biochimie, 1994
This review describes the structure and function of the double-stranded RNA-dependent protein kinase (PKR) and its interaction with RNA activators and inhibitors. The abilities of small virally-encoded RNAs such as VAI RNA of adenovirus, the Epstein-Barr virus encoded (EBER) RNAs and the Tat-responsive region RNA of HIV-1 to bind to and regulate PKR ...
Tyson V. Sharp, Vivienne J. Tilleray, Androulla Elia, Volker Matys, Ken Laing, Ian W. Jeffrey, Michael J. Clemens, Marion C. James, Andrea Schofield   +8 more
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Regulation of eukaryotic protein synthesis by protein kinases that phosphorylate initiation factor eIF-2: Further evidence for a common mechanism of inhibition of protein synthesis

Biochemical and Biophysical Research Communications, 1982
Abstract The role of reversing factor (RF) in the regulation of protein synthesis by inhibitory protein kinases that phosphorylate the 38,000-dalton subunit of initiation factor eIF-2 has been examined. Results show that as with the heme-regulated protein kinase (HRI), RF restores protein synthesis in reticulocyte lysates inhibited by translational ...
Rajinder Singh Ranu
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elF-2 kinases: regulators of general and gene-specific translation initiation

Trends in Biochemical Sciences, 1994
Phosphorylation of eukaryotic initiation factor-2 (eIF-2) is an important mechanism regulating general translation initiation. Two mammalian eIF-2 kinases, the double-stranded-RNA-dependent kinase (PKR) and heme-regulated inhibitor kinase (HRI), have been characterized by sequencing, revealing shared sequence and structural features distinct from other
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Partial purification and characterization of a 90000-dalton peptide involved in activation of the eIF-2.alpha. protein kinase of the hemin-controlled translational repressor

Biochemistry, 1980
In the absence of heme, a negative translational control system is activated in reticulocytes or their lysates that causes the phosphorylation of the smallest subunit of peptide initiation factor 2 and the inhibition of peptide initiation. Two partially purified enzyme fractions are shown to give a concerted effect for phosphorylation of this subunit ...
Boyd Hardesty, Gisela Kramer, Mary H. Wallis   +2 more
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Molecular Cloning and Sequencing of the Human Heme-regulated Eukaryotic Initiation Factor 2 Alpha (eIF-2 Alpha) Kinase from Bone Marrow Culture

DNA Sequence, 2002
The cDNA encoding human heme-regulated eukaryotic initiation factor-2 alpha (eIF-2 alpha) kinase was cloned from a human bone marrow culture. Its deduced amino acid sequence comprised of 629 amino acids with a calculated molecular weight of 71,031 Da.
Yi-Guang Chen, Takeshi Omasa, Athanasios Mantalaris, Ying-Chuech Tsai, J. H. David Wu   +4 more
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Regulation of protein synthesis by heme-regulated eIF-2α kinase

Trends in Biochemical Sciences, 1995
Protein synthesis is regulated by the phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 (eIF-2 alpha) in a variety of cells. At present, there are two distinct mammalian eIF-2 alpha kinases that have been cloned, the double-stranded-RNA-dependent eIF-2 alpha kinase (PKR) and the heme-regulated eIF-2 alpha kinase (HRI).
Irving M. London, Jane-Jane Chen
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Rat Liver pp49, a Protein That Forms Complexes with Protein Kinase CK2, Is Composed of the β and the γ Subunits of Translation Initiation Factor eIF-2

Biochemical and Biophysical Research Communications, 1996
Comparison of the amino acid sequences of two peptides derived from proteolysis of rat liver pp49 identified it as composed of the beta-subunit and the gamma-subunit of eukaryotic initiation factor-2 (eIF-2). Partial purification of rat liver eIF-2 showed that its trimeric form (alpha beta gamma) co-eluted with protein kinase CK2.
Emilio Itarte, Carles Gil, Maria Plana, Marta Riera   +3 more
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