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Interdomain interactions regulate the activation of the heme-regulated eIF2α kinase
Biochimica et Biophysica Acta (BBA) - General Subjects, 2005The heme-regulated inhibitor of protein synthesis (HRI) regulates translation through the phosphorylation of the alpha-subunit of eukaryotic initiation factor-2 (eIF 2). While HRI is best known for its activation in response to heme-deficiency, we recently showed that the binding of NO and CO to the N-terminal heme-binding domain (NT-HBD) of HRI ...
Jessica Matts +2 more
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The eIF-2α kinases: regulators of protein synthesis in starvation and stress
Seminars in Cell Biology, 1994Phosphorylation of translation initiation factor 2 alpha is a highly conserved mechanism for down-regulating protein synthesis in response to starvation or stress. The yeast eIF-2 alpha kinase GCN2 is stimulated by deprivation for amino acids or purines.
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Trends in kinase drug discovery: targets, indications and inhibitor design
Nature Reviews Drug Discovery, 2021Helgi B Schiöth +2 more
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Kinase drug discovery 20 years after imatinib: progress and future directions
Nature Reviews Drug Discovery, 2021Darren Cross +2 more
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Kinase inhibition in autoimmunity and inflammation
Nature Reviews Drug Discovery, 2021Ali A Zarrin +2 more
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Lung cancer: New biological insights and recent therapeutic advances
Ca-A Cancer Journal for Clinicians, 2011Suresh S Ramalingam +2 more
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Treatment of renal cell carcinoma: Current status and future directions
Ca-A Cancer Journal for Clinicians, 2017Pedro Barata, Brian I Rini
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Kinase inhibitors: the road ahead
Nature Reviews Drug Discovery, 2018Fleur M Ferguson, Nathanael S Gray
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