Results 81 to 90 of about 291,615 (215)
The FEBS Journal, Volume 292, Issue 10, Page 2688-2709, May 2025.N6‐methyladenosine is a key mRNA modification that regulates transcript turnover, translation, and other aspects of RNA fate. The m6A‐demethylase ‘eraser’ enzyme FTO reverses this modification. While FTO is known to promote oncogenic signaling in triple‐negative breast cancer, its wider role across the genome and specific downstream signaling has yet ...
Hidde R. Zuidhof +6 more
wiley +1 more source
Resistance to Systemic Agents in Renal Cell Carcinoma Predict and Overcome Genomic Strategies Adopted by Tumor [PDF]
, 2019 The development of new systemic agents has led us into a “golden era” of management of metastatic renal cell carcinoma (RCC). Certainly, the approval of immune-checkpoint inhibitors and the combination of these with targeted compounds has irreversibly ...
Battelli, Nicola +10 more
core +3 more sources
Nuclear to Cytoplasmic Transport Is a Druggable Dependency in HDAC7‐driven Small Cell Lung Cancer
Advanced Science, Volume 12, Issue 14, April 10, 2025.This work reports that a HDAC7‐high SCLC subtype is associated with enhanced proliferation and a poor prognosis. Furthermore, nuclear‐to‐cytoplasmic transport is emerged as a druggable dependency in HDAC7‐mediated SCLC. Elevated HDAC7 predicts increase sensitivity to selinexor both in vitro and in patient‐derived organoids.
Tingting Qin +14 more
wiley +1 more source
Regulation of protein synthesis in rabbit reticulocyte lysates [PDF]
FEBS Letters, 1986 The heme‐regulated protein kinase, which specifically phosphorylates the 38‐kDa subunit of initiation factor eiF‐2, can utilize adenosine 5′‐O‐(3‐thiotriphosphate) (ATP[γS]) as a substrate. The rate of thiophosphorylation is 5‐6‐times slower than that observed with ATP.
openaire +3 more sources
Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors. [PDF]
, 2009 Protein kinase PKR (also known as EIF2AK2) is activated during viral infection and phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF2), leading to inhibition of translation and viral replication. We report fast evolution
Dever, Thomas E +4 more
core
Development and plasticity of the Drosophila larval neuromuscular junction [PDF]
, 2013 The Drosophila larval neuromuscular system is relatively simple, containing only 32 motor neurons in each abdominal hemisegment, and its neuromuscular junctions (NMJs) have been studied extensively.
Carrillo, Robert A. +2 more
core +1 more source
Cancer Medicine, Volume 14, Issue 7, April 2025.ABSTRACT Chemokines, a family of chemotactic cytokines, play a central role in shaping the tumor microenvironment (TME) and in influencing the progression of hepatocellular carcinoma (HCC), a well‐known inflammation‐related cancer. This review addresses the intricate interplay between chemokines and HCC and highlights their multifaceted role.
Jiezuan Yang, Haifeng Lu, Lanjuan Li
wiley +1 more source
Mode of action of the hemin-controlled inhibitor of protein synthesis [PDF]
, 1978 Despite the finding that the hemin-controlled translational inhibitor in reticulocyte lysates is a cyclic AMP-independent protein kinase that phosphorylates the small subunit of the initiation factor eIF-2, the mechanism of inhibition of translation ...
Datta, A., de Haro, C., Ochoa, Severo
core
The Plant Genome, Volume 18, Issue 1, March 2025.Abstract Root‐lesion nematodes (RLN) pose a significant threat to chickpea (Cicer arietinum L.) by damaging the root system and causing up to 25% economic losses due to reduced yield. Worldwide commercially grown chickpea varieties lack significant genetic resistance to RLN, necessitating the identification of genetic variants contributing to natural ...
Ashish Kumar +14 more
wiley +1 more source
Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia [PDF]
, 2013 BACKGROUND: Chemotherapy-induced hair loss (alopecia) (CIA) is one of the most feared side effects of chemotherapy among cancer patients. There is currently no pharmacological approach to minimize CIA, although one strategy that has been proposed ...
Chu, Jennifer +9 more
core +2 more sources