Results 201 to 210 of about 2,235,192 (340)

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Frequency of Anemia in Patients With Heart Failure With Preserved Ejection Fraction (HFpEF). [PDF]

Cureus
Ahmed N, Shaikh K, Kumar A, Bai E, Kour S, Fatima F.   +5 more
europepmc   +1 more source

291 Real-time, quantitative assessment of left ventricular ejection fraction and regional wall motion by speckle imaging [PDF]

, 2006
Marina Leitman, Peter Lysyansky, Zvi Vered   +2 more
openalex   +1 more source

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Pathogenesis and Therapeutic Advances in Heart Failure with Preserved Ejection Fraction. [PDF]

Rev Cardiovasc Med
Fan X, Ma J, Zhao X, Yu J.
europepmc   +1 more source

Non-coding RNAs in the pathophysiology of heart failure with preserved ejection fraction [PDF]

Elisabeth A. Jalink, Amber W. Schonk, Reinier A. Boon, Rio P. Juni   +3 more
openalex   +1 more source

P6176Feasibility of handgrip exercise test for detection of early heart failure with preserved ejection fraction compared to bicycle exercise test (invasive hemodynamic study) [PDF]

, 2017
Hyun Seok Hwang, KyungJun Kim, Koung Mi Kang, P.H.W. Park, Kyung-Cheol Koh, P.J.R. Park, Hye Jeong Hwang   +6 more
openalex   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Heart Failure With Mildly Reduced Ejection Fraction: A Call for a Precision Medicine Approach. [PDF]

JACC Adv
Wu L, Rizwan A, Rodriguez M, El Hachem K, Hassan Virk HU, Khawaja M, Strauss M, Krittanawong C.   +7 more
europepmc   +1 more source

2060Prognostic relevance of preclinical diastolic dysfunction across left ventricular ejection fraction categories. The DAVID-Berg study [PDF]

, 2017
Mauro Gori, Alice Calabrese, Paolo Canova, Giovanni Cioffi, Renata De Maria, A Grosu, Attilio Iacovoni, Alessandra Fontana, Paola Ferrari, Gianfranco Parati, Antonello Gavazzi, Michele Senni   +11 more
openalex   +1 more source