Results 121 to 130 of about 101,796 (243)

Elastin and the lung. [PDF]

Thorax, 1986
openaire   +2 more sources

Effects of Bone Morphogenetic Protein‐7 on Steroid‐Induced Extracellular Matrix Accumulation in Human Trabecular Meshwork Cells

FASEB BioAdvances, EarlyView.
Long‐term steroid use can elevate intraocular pressure (IOP) and lead to steroid‐induced glaucoma by promoting extracellular matrix (ECM) accumulation in the trabecular meshwork (TM). This study demonstrates that bone morphogenetic protein‐7 (BMP‐7), delivered via a micellized protein transduction domain (mPTD), effectively inhibits steroid‐induced ECM
Eun Woo Kim, Jin‐Ok Choi, Min Kyung Chae, Jin‐Sol Lee, Chang Ha Lee, Jo Eun Um, Nam Hee Kim, Jihyeong Kim, Wungrak Choi, Chan Yun Kim   +9 more
wiley   +1 more source

Elastin Peptides as a Potential Disease Vector in the Pathogenesis of Pulmonary Emphysema: An Investigation of This Hypothesis. [PDF]

Life (Basel)
Cantor J.
europepmc   +1 more source

Compressive Forces Induce Epigenetic Activation of Aged Human Dermal Fibroblasts Through ERK Signaling Pathway

Aging Cell, EarlyView.
Direct activation and rejuvenation of aged fibroblasts through the application of mechanical forces in a 3D spheroid culture model. The ERK signaling pathway was revealed as a key underlying mechanism. ABSTRACT Age‐related changes in human dermal fibroblasts (HDFs) contribute to impaired wound healing and skin aging.
Hui Liu, Luezhen Yuan, Lucrezia Baldi, Trinadha Rao Sornapudi, G. V. Shivashankar   +4 more
wiley   +1 more source

Skin Photoprotection and Anti-Aging Benefits of a Combination of Rosemary and Grapefruit Extracts: Evidence from In Vitro Models and Human Study. [PDF]

Int J Mol Sci
Navarro P, Castillo J, Jones J, García A, Caturla N.   +4 more
europepmc   +1 more source

Dietary Restriction Mitigates Vascular Aging, Modulates the cGAS‐STING Pathway and Reverses Macrophage‐Like VSMC Phenotypes in Progeroid DNA‐Repair‐Deficient Ercc1Δ/− Mice

Aging Cell, EarlyView.
Dietary restriction mitigates vascular aging in DNA‐repair‐deficient Ercc1Δ/− mice by reducing extracellular matrix remodeling, inflammation, oxidative stress, and switching of vascular smooth muscle cells to a macrophage‐like phenotype. Our findings suggest that the cGAS‐STING pathway plays a key role in vascular aging and that the benefits of dietary
S. J. M. Stefens, J. van der Linden, J. M. Heredia‐Genestar, R. M. C. Brandt, S. Barnhoorn, I. Nieuwenhuizen‐Bakker, N. van Vliet, J. H. M. Odijk, Y. Ridwan, D. Stuijts, M. Batenburg, J. H. J. Hoeijmakers, R. Kanaar, J. Essers, I. van der Pluijm   +14 more
wiley   +1 more source

Comprehensive Quantification of Collagen, Elastin, and Glycosaminoglycans in the Human Facial Dermis: Insights From a Pilot Study. [PDF]

Cureus
Bouchelkia I, Sadacharan C.
europepmc   +1 more source

Late Life Supplementation of 25‐Hydroxycholesterol Reduces Aortic Stiffness and Cellular Senescence in Mice

Aging Cell, EarlyView.
25‐hydroxycholesterol (25HC) targets senescent cell anti‐apoptotic pathways (SCAPs) to reduce vascular cell senescence, favorably remodel aortic wall components, and reduce aortic stiffening with advancing age. ABSTRACT Stiffening of the aorta is a key antecedent to cardiovascular diseases (CVD) with aging.
Sophia A. Mahoney, Mary A. Darrah, Ravinandan Venkatasubramanian, Serban Ciotlos, Matthew J. Rossman, Judith Campisi, Douglas R. Seals, Simon Melov, Zachary S. Clayton   +8 more
wiley   +1 more source

Variations in stiffness and structure of the human aorta along its length. [PDF]

Sci Rep
Shahbad R, Kazim M, Razian SA, Desyatova A, Jadidi M.   +4 more
europepmc   +1 more source

Serum Biomarkers of Extracellular Matrix Remodeling in Ulcerative Colitis—One Step Closer to Fibrosis Biomarkers in Inflammatory Bowel Disease

United European Gastroenterology Journal, EarlyView.
Helena Tavares de Sousa, Raquel Oliveira
wiley   +1 more source