Results 71 to 80 of about 70,233 (296)

Background-deflection Brillouin microscopy reveals altered biomechanics of intracellular stress granules by ALS protein FUS [PDF]

, 2018
Altered cellular biomechanics have been implicated as key photogenic triggers in age-related diseases. An aberrant liquid-to-solid phase transition, observed in in vitro reconstituted droplets of FUS protein, has been recently proposed as a possible ...
Antonacci, Giuseppe, DE TURRIS, Valeria, Rosa, Alessandro, Ruocco, Giancarlo   +3 more
core   +3 more sources

AI‐Enhanced Vibrational Capsule for Minimally Invasive Detection of Abnormal Bowel Tissue

Advanced Science, EarlyView.
A fully integrated vibration‐assisted capsule is presented for the minimally invasive detection of bowel lesions. The capsule incorporates a wireless sensor and an eccentric motor to probe tissue mechanics in situ. By coupling triaxial vibration signals with AI‐based classification and analytical modeling, the system enables early, non‐visual ...
Xizheng Fang, Yao Yan, Kenneth Omokhagbo Afebu, Andrew Bickerdike, Bo Tian, Yang Liu, Shyam Prasad   +6 more
wiley   +1 more source

Diagnosis of Thyroid Nodules by Elastography

Journal of Surgical Ultrasound, 2021
Ultrasonography is mandatory for the evaluation of thyroid nodules. Although B-mode and Doppler ultrasonography are both sensitive for the diagnosis of thyroid lesions, they lack specificity in differentiating benign from malignant nodules.
Hyun Jo Youn, Ha Rim Ahn, Sang Yull Kang, Sung Hoo Jung   +3 more
doaj   +1 more source

Interferon free antiviral treatment of chronic hepatitis C in patients affected by β-thalassemia major [PDF]

, 2017
Chronic hepatitis C (CHC) significantly affects the prognosis of liver disease [1] and health related quality of life (HRQOL) in patients with β-thalassemia major [2, 3].
Biliotti, Elisa, Esvan, Rozenn, Franchi, Cristiana, Palazzo, Donatella, Serani, Marco, Silvestri, Alessandro M., Sorrentino, Francesco, Spaziante, Martina, Taliani, Gloria, Volpicelli, Lorenzo   +9 more
core   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Endothelial protection in patients with coronary heart disease in combination with COVID-19: aspects of the different therapeutic strategies

Infusion & Chemotherapy
BACKGROUND. Coronavirus disease 2019 (COVID-19) and coronary heart disease (CHD) are pandemics, their synergy significantly affects population morbidity and mortality.
O.B. Dynnyk, S.Ye. Mostovyi, N.M. Bobok, V.Ye. Medvediev   +3 more
doaj   +1 more source

Ultrasound Vascular Elastography as a Tool for Assessing Atherosclerotic Plaques – A Systematic Literature Review

Ultrasound International Open, 2016
Atherosclerosis is a widespread disease that accounts for nearly 3-quarters of deaths due to cardiovascular disease. Ultrasound elastography might be able to reliably identify characteristics associated with vulnerable plaques.
B. Mahmood, C. Ewertsen, J. Carlsen, M. B. Nielsen   +3 more
doaj   +1 more source

Endobronchial ultrasound elastography

Endoscopic Ultrasound, 2016
Elastographic techniques have recently become available as advanced diagnostic tools for tissue characterization. Strain elastography is a real-time technique used with transcutaneous ultrasound (US) and endoscopic US. Convincing evidence is available demonstrating a significant value of strain elastography for the discrimination of benign and ...
Dietrich, Christoph F., Jenssen, Christian, Herth, Felix J. F.   +2 more
openaire   +3 more sources

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Intervertebral disc characterization by shear wave elastography: an in-vitro preliminary study [PDF]

, 2014
Patient-specific numerical simulation of the spine is a useful tool both in clinic and research. While geometrical personalization of the spine is no more an issue, thanks to recent technological advances, non-invasive personalization of soft tissue’s ...
BONNEAU, Dominique, DUBOIS, Guillaume, DUBOUSSET, Jean, GENNISSON, Jean-Luc, ROUCH, Philippe, SKALLI, Wafa, TANTER, Mickael, VERGARI, Claudio, VERGARI, Claudio   +8 more
core   +4 more sources