Results 141 to 150 of about 1,622,974 (278)

Bringing Gene Therapy Into Real World Clinical Practice

Haemophilia, EarlyView.
ABSTRACT Introduction Adeno‐associated virus (AAV)‐based gene therapy for haemophilia has shifted therapeutic paradigms by enabling hepatic gene transfer, restoring endogenous clotting factor expression, and reducing reliance on conventional prophylactic treatments. Two products, valoctocogene roxaparvovec (haemophilia A) and etranacogene dezaparvovec (
Wolfgang Miesbach, Pratima Chowdary, Margareth C. Ozelo   +2 more
wiley   +1 more source

Splenic Stiffness Measurement: A New Frontier in the Management of Pediatric Portal Hypertension

Portal Hypertension &Cirrhosis, EarlyView.
Samannay Das, Tamoghna Biswas
wiley   +1 more source

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

A new 5-grading score in the diagnosis of prostate cancer with real-time elastography.

International journal of clinical and experimental pathology, 2015
To evaluate the clinical significance of transrectal real-time elastography (TRTE) in diagnosis of prostate cancer (PCA).195 patients with an elevated PSA level were enrolled in the study. A novel 5-grading score of prostate outer gland was applied by TRTE imaging.
Guang, Xu, Lijing, Feng, Minghua, Yao, Jian, Wu, Lehang, Guo, Xudong, Yao, Lixia, Zhao, Huixiong, Xu, Rong, Wu   +8 more
openaire   +1 more source

Validation of the Baveno Endoscopy Avoidance Criteria in Japanese Patients With Chronic Liver Disease: A Real‐World Cohort Study

Hepatology Research, EarlyView.
Many patients with chronic liver disease can safely avoid unnecessary screening endoscopy using the Baveno VII criteria. We developed a simple three‐factor score to identify patients at high risk of serious esophageal varices. Using both approaches together may improve the efficiency and safety of endoscopic screening.
Maiko Asami, Yoshihito Uchida, Shohei Tsuji, Satsuki Ando, Kayoko Sugawara, Masamitsu Nakao, Nobuaki Nakayama, Yukinori Imai, Suguru Mizuno, Satoshi Mochida   +9 more
wiley   +1 more source

Sonographic elastography combined with conventional sonography: how much is it helpful for diagnostic performance? [PDF]

, 2009
OBJECTIVE: The purpose of this study was to evaluate the diagnostic performance of conventional sonography combined with sonographic elastography for differentiation between benign and malignant breast lesions and to assess the diagnostic performance ...
손유미, 곽진영, 문희정, 김수진, 김은경, 김민정   +5 more
core  

Cisterna Chyli Dilation Is a Risk Factor for Liver Nodules and Hepatocellular Carcinoma in Fontan‐Associated Liver Disease: Pathophysiological Role of Lymphatic Dysfunction

Hepatology Research, EarlyView.
ABSTRACT Aim In Fontan‐associated liver disease (FALD), chronic congestion often confounds conventional fibrosis markers, complicating surveillance for hepatocellular carcinoma (HCC). Although lymphatic dysfunction is fundamental to Fontan physiology, its contribution to hepatocarcinogenesis remains unclear.
Koji Imoto, Masatake Tanaka, Takeshi Goya, Yuuki Azuma, Tomonobu Hioki, Yusuke Morita, Keisuke Sakaguchi, Nobuhiro Fujita, Takamori Kakino, Ayako Ishikita, Kenichiro Yamamura, Ichiro Sakamoto, Kousei Ishigami, Kohtaro Abe, Yoshihiro Ogawa   +14 more
wiley   +1 more source

Role of FibroScan in evaluating hepatic involvement in systemic amyloidosis: a single‐centre prospective pilot study

Internal Medicine Journal, EarlyView.
Abstract Background Amyloidosis encompasses a group of diseases characterised by extracellular deposition of misfolded protein fibrils, potentially leading to organ dysfunction. Liver involvement occurs via direct amyloid infiltration, common in immunoglobulin light chain (AL) amyloidosis, or congestive hepatopathy, more typical in transthyretin (ATTR)
M Tang, N Vootukuru, J Tjahyadi, D Clayton Chubb, H Jina, SB Ting, S Bloom, R Sawhney, S Gibbs, O. Niewiadomski   +9 more
wiley   +1 more source

Changes in liver steatosis and liver stiffness following Empagliflozin treatment in patients with MASLD and type 2 diabetes: A single‐arm pre–post study

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) is common in subjects with type 2 diabetes mellitus (T2DM), being linked to a higher risk for the development of liver‐related and cardiovascular diseases.
Mobina Shieh, Davood Dalil, Alireza Arefzadeh, Maryam Shiehmorteza   +3 more
wiley   +1 more source

Optimizing surgery in hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Surgery in hidradenitis suppurativa should be matched to disease extent. A structured six‐step approach—comprehensive assessment, optimal timing, ultrasound‐guided mapping, tailored intervention, individualized reconstruction and structured wound care—integrated with targeted systemic therapy optimizes outcomes and reduces recurrence.
Eva Vilarrasa, Philippe Guillem, Barbara Horváth, Marco Romanelli, Carolin E.Frost, Falk G. Bechara, Øystein Grimstad, Antonio Martorell   +7 more
wiley   +1 more source