Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Potentially inappropriate medication use among Brazilian elderly in a medication management program
, 2016 Vanessa Mayra de Oliveira Mauricio +3 more
openalex +1 more source
The Association of Stage 1 Hypertension Defined by the 2017 ACC/AHA Guideline with Stroke and Its Subtypes among Elderly Chinese [PDF]
, 2020 Jinyue Gao +10 more
openalex +1 more source
Zinc Supplementation Partially Reconstitutes Impaired Interferon-γ Production in the Elderly. [PDF]
Int J Mol SciOlah K +5 more
europepmc +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Night-to-Night Variability of Disturbed Breathing During Sleep in an Elderly Community Sample [PDF]
, 1991 Stephen R. Lord +9 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Overcoming Barriers and Increasing Independence – Service Robots for Elderly and Disabled People [PDF]
, 2015 Marion Hersh
openalex +1 more source
Improving the predictive validity of acute Kidney Injury after hip fracture Surgery in elderly ICU patients-A focus on "Acute Kidney Injury after hip fracture surgery among elderly patients in the ICU: incidence, risk factors and their predictive value, clinical impact-A retrospective single-center study". [PDF]
Ren FailZhang B, Yu R, Xu W, Li H, Qi P.
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source