Results 231 to 240 of about 3,263,574 (391)

Regional distribution of pulmonary ventilation and perfusion in elderly subjects [PDF]

, 1968
Janet E. Holland, J. Milic‐Emili, Peter T. Macklem, David V. Bates   +3 more
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Breaking age barriers: the efficacy of ERCP in advanced age patients. [PDF]

BMC Surg
Li Z, Qiao Z, Wang W, Sun Y, Sun D, Sheng M.   +5 more
europepmc   +1 more source

Short‐Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma

New England Journal of Medicine, 2017
J. Perry, N. Laperriere, C. O'Callaghan, A. Brandes, J. Menten, C. Phillips, M. Fay, R. Nishikawa, G. Cairncross, W. Roa, D. Osoba, J. Rossiter, A. Sahgal, H. Hirte, F. Laigle-Donadey, E. Franceschi, O. Chinot, V. Golfinopoulos, L. Fariselli, A. Wick, L. Feuvret, M. Back, M. Tills, C. Winch, B. Baumert, W. Wick, K. Ding, W. Mason   +27 more
semanticscholar   +1 more source

The food purchases of elderly women living alone: a statistical inconsistency and its investigation [PDF]

, 1964
B. S. Platt, Phyllis Gray, Elizabeth Parr, A. H. J. Baines, Stephanie Clayton, Elizabeth Anne Hobson, Dorothy F. Hollingsworth, W. T. C. Berry, Elizabeth A. Washington   +8 more
openalex   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source

Inequality in opportunities for utilizing community-based care services among the elderly in China - an analysis based on the "circumstance-effort" perspective. [PDF]

BMC Health Serv Res
Jiang H, Huang Y.
europepmc   +1 more source

Do Coresidency with and Financial Transfers from Children Reduce the Need for Elderly Parents to Work in Developing Countries? [PDF]

What drives the labor supply decisions of the elderly in developing countries? To what extent do elderly parents use coresidence with or financial transfers from children to reduce their own labor supply in old age?
Deborah Cobb-Clark, Lisa A Cameron
core  

A single gene mutation predicts response to immune checkpoint blockade in ovarian clear cell carcinoma

Molecular Oncology, EarlyView.
Loss‐of‐function mutations in the scaffold subunit of protein phosphatase 2A (PP2A), PPP2R1A, sensitize ovarian clear cell carcinoma to immune checkpoint blockade (ICB) by enhancing the interferon gamma response and promoting antitumor immune cell infiltration.
Matheus Henrique Dias, René Bernards
wiley   +1 more source