Results 291 to 300 of about 2,744,109 (362)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Clinical outcomes of thoracic radiotherapy in combination with chemoimmunotherapy in elderly patients with extensive-stage small cell lung cancer. [PDF]

Precis Radiat Oncol
Han J, Zheng W, Jiang J, Shi H, Liu C.
europepmc   +1 more source

Physiological responses of elderly recreational alpine skiers of different fitness and skiing abilities.

, 2011
Sabine Krautgasser, Peter Scheiber, Serge P. von Duvillard, Erich Müller   +3 more
openalex   +1 more source

Nutritional vulnerability and its associated characteristics among the elderly in Seoul: analysis of data from the Seoul food survey 2024. [PDF]

Front Nutr
Lee M, Nam Y, Yoo HJ, Yoon J.
europepmc   +1 more source

Decreasing admissions in older and increasing mortality in younger patients: a nationwide observational study of all German ICU cases 2011-2022. [PDF]

Crit Care
Thomsen SY, Kakavand N, von Samson-Himmelstjerna FA, Eitel I, Jung C, Schmitt R, Schulte K, Kolbrink B.   +7 more
europepmc   +1 more source

Ageing of the Oral Mucosa: Mechanisms and Consequences. [PDF]

Int Dent J
Qiu C, Jie W, Qian Y, Lu X, Chen Y, Si M.   +5 more
europepmc   +1 more source

Application of Enhanced Recovery After Surgery in high-risk patients undergoing colon cancer surgery: a retrospective cohort study. [PDF]

Ann Surg Treat Res
Alshiakh RMH, Kim IK, Bae JH, Lee YS, Lee IK.   +4 more
europepmc   +1 more source