Results 61 to 70 of about 806,757 (266)

Dynamic Changes in ALFF and DC in Subthreshold Depression Before and After ICBT Intervention

Neuropsychiatric Disease and Treatment
Yu Wang,1,* Yuchen Ying,2,* Zili Zhu,1 Li Wang,2 YiLing Yang,2 Li Zhang,2 Wenquan Yu,1 Yichuan Liang,1 Hui Zhang,1 Yunxin Ji,3 Yuning Pan1 1Department of Radiology, THE First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang ...
Wang Y, Ying Y, Zhu Z, Wang L, Yang Y, Zhang L, Yu W, Liang Y, Zhang H, Ji Y, Pan Y   +10 more
doaj  

Diabetes in Elderly

Collegium antropologicum, 2015
Diabetes is a major public health problem in the world and one of the leading causes of morbidity and mortality from cardiovascular and chronic kidney disease. Aging of the population is expected to further increase the prevalence of type 2 diabetes, particularly in the age group over 65. According to the 2011 census, in Croatia, 17.7% of thepopulation
Vrdoljak, Davorka, Pavlov, Renata
openaire   +4 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Process of implementing and delivering the Prevention of Delirium system of care: a mixed method preliminary study

BMC Geriatrics, 2019
Background Delirium is a frequent complication of hospital admission among older people. Multicomponent interventions which can reduce incident delirium by ≈one-third are recommended by the National Institute of Health and Care Excellence.
Mary Godfrey, John Green, Jane Smith, Francine Cheater, Sharon K. Inouye, Keith Hurst, John Young   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Association of multimorbidity and its patterns with risk of mortality among the elderly in Shenzhen, China

BMC Geriatrics
Objective This study aimed to identify multimorbidity pattern in the elderly population, and to investigate the associations of multimorbidity and its patterns with risk of mortality. Methods A total of 107,217 participants aged ≥ 65, with 47,205 men and
Yijin Zheng, Xueli Yuan, Wenqing Ni, Hongmin Zhang, Yan Zhang, Yuan Wei, Jian Xu   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Factors related to intentional non-initiation of bisphosphonate treatment in patients with a high fracture risk in primary care: a qualitative study

BMC Family Practice, 2018
Background Adherence to osteoporosis treatment is crucial for good treatment effects. However, adherence has been shown to be poor and a substantial part of the patients don’t even initiate treatment.
Karin M. A. Swart, Myrthe van Vilsteren, Wesley van Hout, Esther Draak, Babette C. van der Zwaard, Henriette E. van der Horst, Jacqueline G. Hugtenburg, Petra J. M. Elders   +7 more
doaj   +1 more source