Results 141 to 150 of about 7,855,345 (303)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Antithrombotic therapies for elderly patients: handling problems originating from their comorbidities

, 2018
Masahisa Arahata, Hidesaku Asakura Department of Hematology, Graduate School of Medicine of Kanazawa University, Kanazawa, Ishikawa, Japan Abstract: Compared with younger people, elderly people have higher risks for both thrombosis and bleeding ...
Asakura H, Arahata M
core  

Clinical remission in elderly patients with sarcoidosis. [PDF]

Sarcoidosis Vasc Diffuse Lung Dis
Yatagai Y, Maezawa Y, Shiozawa T, Ohara G, Satoh H.   +4 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Nurses' knowledge and practice towards home palliative care of elderly patients. [PDF]

Palliat Care Soc Pract
Baker OG, Alrasheedi FH, Almutairi AM, Alluhebi RS, Hamid Al Dhafer NA.   +4 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Urological surgery in elderly patients: results and complications

, 2015
Milos Brodak, Jan Tomasek, Jaroslav Pacovsky, Lukas Holub, Petr Husek Department of Urology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic Purpose: Owing to the large aging population, a growing number of elderly patients are ...
Brodak M, Husek P, Tomasek J, Holub L, Pacovsky J   +4 more
core  

Hemodynamic safety of remimazolam <i>vs</i> propofol in elderly patients. [PDF]

World J Gastrointest Pharmacol Ther
Tahir N, Khan A, Faryal S, Faizan M, Irshad A, Iqbal U, Wasay M, Arsal SA, Kumar A, Okon II, Amin SB.   +10 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Oral glycogenic acanthosis: variable clinical presentations in three elderly patients. [PDF]

An Bras Dermatol
Monteiro F, Tribolet-Abreu I, Almeida-Silva G, de Vasconcelos P, Fernandes S, Antunes J.   +5 more
europepmc   +1 more source