Results 211 to 220 of about 1,488,212 (358)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Dupilumab in Elderly Patients with Atopic Dermatitis-A Systematic Review and Meta-Analysis. [PDF]

Biomedicines
Hałubiec P, Gołąbek N, Wojas-Pelc A, Szepietowski JC, Jaworek AK.   +4 more
europepmc   +1 more source

Determinants and predictive performance of reduced muscle mass in elderly patients with type 2 diabetes: a retrospective study [PDF]

Kaili Wang, Weitao Fu, Haiqiao Pan, Jianjun Dong   +3 more
openalex   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Cardiac autonomic function in elderly patients with and without atrial fibrillation. [PDF]

Eur Heart J Open
Hämmerle P, Schier J, Rizas KD, Schlageter V, Kaplan E, Aeschbacher S, Rast M, Krisai P, Coslovsky M, Reichlin T, Bardoczi JB, Rodondi N, Müller AS, Bernheim AM, Moschovitis G, De Perna ML, Conen D, Sticherling C, Osswald S, Bauer A, Mahfoud F, Kühne M, Zuern CS.   +22 more
europepmc   +1 more source

A case of myoepithelial carcinoma ex pleomorphic adenoma in the buccal region of a very elderly patient

Motoki Yahara, Mitsunobu ONO, Hideka NAGAMORI TAKAHASHI, Kyoko YAMAGUCHI, Suguru KAMADA, Eiji Nakamura   +5 more
openalex   +2 more sources

High prevalence of wild-type transthyretin deposition in patients with idiopathic carpal tunnel syndrome: a common cause of carpal tunnel syndrome in the elderly

, 2011
Yoshiki Sekijima, Shigeharu Uchiyama, Kana Tojo, Kenji Sano, Yusaku Shimizu, Toshihiko Imaeda, Yoshibonu Hoshii, Hiroyuki Kato, Shu‐ichi Ikeda   +8 more
openalex   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Efficacy and safety of different doses of ciprofol for general anesthesia induction in elderly patients undergoing hip replacement surgery: a randomized, double-blind, controlled clinical trial

Xiao Tian, Haojun Sun, Yugang Diao, Bin Zou, Zitong Xu, Chunlin Yao, Li Li   +6 more
openalex   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source