Results 241 to 250 of about 1,488,212 (358)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Utilization of Apixaban Pharmacokinetics for Dose Optimization in High-Risk Elderly Patients. [PDF]

Clin Pharmacokinet
Goldstein R, Sandouka K, Zighan L, Ya'ari S, Bialer M, Muszkat M.   +5 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Cognitive Impact of Colorectal Cancer Surgery in Elderly Patients: A Narrative Review. [PDF]

Cancers (Basel)
Filho OM, Alves Martins BA, Colles T, de Almeida RM, de Sousa JB.   +4 more
europepmc   +1 more source

Elderly Cancer Patients’ Use of Hope and Faith-Based Services: Social Workers’ Perspectives

, 2013
Katie Lynn Thayer
openalex   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Transoral Robotic Surgery for Elderly Patients with Oropharyngeal and Laryngeal Cancer: A Comprehensive Review. [PDF]

J Clin Med
Russo E, Porcuna DV, Gorphe P, Paleri V, Pellini R, Costantino A, Accorona R, De Virgilio A.   +7 more
europepmc   +1 more source

Epidemiological Profile and Risk Factors of Hip Fractures in Elderly Patients: A Retrospective Study

Rajendra Bhandari, Sunita Bhandari, Nusrat Gaffoor   +2 more
openalex   +1 more source