Results 51 to 60 of about 5,962,888 (299)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Dietary assessment methods for micronutrient intake in elderly people: a systematic review [PDF]

, 2009
The European micronutrient recommendations aligned (EURRECA) Network of Excellence seeks to establish clear guidelines for assessing the validity of reported micronutrient intakes among vulnerable population groups.
Jorge Doreste-Alonso, Serra-Majem, L., Vries, Jeanne de, Lluís Serra-Majem, de Vries, J.H.M., Groot, C.P.G.M., de, Almudena Sánchez-Villegas, Groot, Lisette de, Vries, J.H.M., de, Ortiz-Andrellucchi, A., Sanzech-Villegas, A., de Groot, C.P.G.M., Jeanne de Vries, Ortiz-Andrellucchi, Adriana, Doreste-Alonso, Jorge, Doreste-Alonso, J., Adriana Ortiz-Andrellucchi, Serra-Majem, Lluís, Lisette de Groot, Sánchez-Villegas, Almudena   +19 more
core   +1 more source

The vulnerability of rural elderly Indonesian people to disability: an analysis of the national socioeconomic survey

Rural and Remote Health, 2021
Introduction: There is a high prevalence of elderly people aged 65 years and older with disabilities in low- and middle-income countries, including Indonesia. This study examined urban-rural disparities in disabilities among elderly Indonesian people by
Mardiana Puspitasari, Mugia Rahardja, Maria Gayatri, Adhi Kurniawan   +3 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

ANALISIS KUNJUNGAN LANSIA DALAM KEGIATAN POSYANDU DI WILAYAH KERJA PUSKESMAS PINTU LANGIT KEC. PADANGSIDIMPUAN ANGKOLA JULU KOTA PADANGSIDIMPUAN TAHUN 2019

JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan), 2020
Overcoming a variety of health problems for the elderly, the government has made various health care policies for elderly people, one of them is the posyandu for the elderly.
Betti Agustina Nasution, Namora Lumongga Lubis, Tengku Moriza   +2 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Localised erythema nodosum leprosum—A rare entity managed with thalidomide

Skin Health and Disease
Leprosy is caused by Mycobacterium leprae. The condition primarily affects the skin and peripheral nerves. There are two types of leprosy reactions, Type 1 and Type 2 or erythema nodosum leprosum (ENL).
Chandni Patel, Barbara De Barros, Stephen L. Walker   +2 more
doaj   +1 more source

Oral health status of elderly people in Rome-Italy

Senses and Sciences, 2014
Background: Actually there is no survey on the oral health of elderly in Lazio region or in Rome. Study aims to assess the dental and oral health status and treatments needs of the elderly population in Rome in order to assess need for care. Materials
Licia Manzon, Evaristo Ettorre, Eros Rossi, Laith Kostantino Besharat, Piero Romanelli, Giovanni Fratto   +5 more
doaj   +1 more source

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

Aging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara, Takashi Kawahara, Kazuhide Makiyama, Hiroji Uemura   +3 more
wiley   +1 more source