Results 11 to 20 of about 40,530 (210)

Effects of specific inhibition of sterol biosynthesis on the uptake and utilization of low density lipoprotein cholesterol by HepG2 cells.

Journal of Lipid Research, 1991
Treatment of HepG2 cells in lipoprotein-deficient media with 4,4,10 beta-trimethyl-trans-decal-3 beta-ol (TMD) abolished the incorporation of [3H]acetate into cholesterol with concomitant accumulation of squalene 2,3(S)-oxide and squalene 2,3(S):22(S),23-
SR Panini, GT Everson, TA Spencer
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Endogenous sterol synthesis is not required for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by low density lipoprotein

Journal of Lipid Research, 1987
It has been proposed that an endogenously synthesized oxysterol mediates the regulation of cholesterol biosynthesis by low density lipoprotein in cultured mammalian cells.
E Burki, J Logel, M Sinensky
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Thirty-Two Teeth, Thirty-Two Challenges: Memoirs of a Dentist Turned Policy Maker

Nigerian Dental Journal, 2023
According to Eleanor Roosevelt, “memoirs are only useful as the lives you read about and analyse may suggest to you something that you may find useful in your own journey through life.” I am therefore glad to state that I see myself quite relevant to ...
Adebimpe Adebiyi
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Pauli Murray: Human Rights Visionary and Trailblazer

AJIL Unbound, 2023
While other scholars have discussed Dr. Pauli Murray's remarkable contributions to race and sex equality law,1 few, if any, have placed her contributions within the context of the broader tradition of human rights law.
Darin E. W. Johnson, Catherine Powell
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A Cystine-Rich Whey Supplement (Immunocal®) Delays Disease Onset and Prevents Spinal Cord Glutathione Depletion in the hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

Antioxidants, 2014
Depletion of the endogenous antioxidant, glutathione (GSH), underlies progression of the devastating neurodegenerative disease, amyotrophic lateral sclerosis (ALS). Thus, strategies aimed at elevating GSH may yield new therapeutics for ALS.
Erika K. Ross, Aimee N. Winter, Heather M. Wilkins, Whitney A. Sumner, Nathan Duval, David Patterson, Daniel A. Linseman   +6 more
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Reduced purine biosynthesis in humans after their divergence from Neandertals

eLife, 2021
We analyze the metabolomes of humans, chimpanzees, and macaques in muscle, kidney and three different regions of the brain. Although several compounds in amino acid metabolism occur at either higher or lower concentrations in humans than in the other ...
Vita Stepanova, Kaja Ewa Moczulska, Guido N Vacano, Ilia Kurochkin, Xiangchun Ju, Stephan Riesenberg, Dominik Macak, Tomislav Maricic, Linda Dombrowski, Maria Schörnig, Konstantinos Anastassiadis, Oliver Baker, Ronald Naumann, Ekaterina Khrameeva, Anna Vanushkina, Elena Stekolshchikova, Alina Egorova, Anna Tkachev, Randall Mazzarino, Nathan Duval, Dmitri Zubkov, Patrick Giavalisco, Terry G Wilkinson, David Patterson, Philipp Khaitovich, Svante Pääbo   +25 more
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The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord

Frontiers in Cellular Neuroscience, 2018
The molecular mechanisms leading to motor neuron death in amyotrophic lateral sclerosis (ALS) are unknown; however, several studies have provided evidence of a central role for intrinsic apoptosis.
Nathan Duval, Whitney A. Sumner, Anna G. Andrianakos, Josie J. Gray, Ron J. Bouchard, Heather M. Wilkins, Daniel A. Linseman   +6 more
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First Female Travel Journalist Meets First Lady: Mary Pos and Eleanor Roosevelt Speak on Women’s Roles and Intercultural Understanding

European Journal of American Studies, 2017
Mary Pos, self-proclaimed first female travel journalist from the Netherlands, met Eleanor Roosevelt first in 1937 during a women-only press conference at the White House, and then in 1950 when Roosevelt visited Amsterdam.
Babs Boter
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The CRISPR-Cas9 crATIC HeLa transcriptome: Characterization of a novel cellular model of ATIC deficiency and ZMP accumulation

Molecular Genetics and Metabolism Reports, 2020
In de novo purine biosynthesis (DNPS), 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (EC 2.1.2.3)/inosine monophosphate cyclohydrolase (EC 3.5.4.10) (ATIC) catalyzes the last two reactions of the pathway: conversion of 5-aminoimidazole ...
Randall C. Mazzarino, Veronika Baresova, Marie Zikánová, Nathan Duval, Terry G. Wilkinson, II, David Patterson, Guido N. Vacano   +6 more
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Crianças refugiadas que se salvaram através de Portugal durante a Segunda Guerra Mundial (1940-1944)

Revista de História da Sociedade e da Cultura, 2022
Durante a Segunda Guerra Mundial (1939-1945) e, sobretudo, a partir de 1940, ano das principais ocupações e anexações da Europa Ocidental por parte do exército alemão, centenas de crianças em fuga encontraram refúgio provisório neste pequeno, pobre e ...
Carolina Henriques Pereira
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