Results 51 to 60 of about 4,334 (251)

Ocular injuries associated with two-wheeled electric transportation devices and motorcycle accidents

open access: yesScientific Reports, 2022
Electric bicycles and scooters have gained popularity among riders; studies assessing these device-related injuries have not specified ocular trauma.
Omer Lev Ari   +6 more
doaj   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

open access: yesAdvanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen   +15 more
wiley   +1 more source

Charting the Future of Stereoselective Carbohydrate Synthesis: The Essential Role of Cross‐Disciplinary Innovation

open access: yesAdvanced Science, EarlyView.
Cross‐disciplinary endeavors are blossoming across the broad chemical sciences. This perspective provides a glimpse into the rewarding interdisciplinary journey taken by the Charles Loh research group in pioneering the σ‐hole based catalytic glycosylation strategy.
Charles C. J. Loh
wiley   +1 more source

Renal Clearable Luminogenic Reporter for Ultrasensitive Influenza Virus Imaging and Efficient Antiviral Therapies Monitoring in Living Mice

open access: yesAdvanced Science, EarlyView.
A viral luminogenic reporter with chemiluminescence/fluorescence dual‐response and efficient renal clearance was developed for non‐invasive imaging and urinalysis of H1N1 virus protease, allowing for remote detection of H1N1 virus infections and monitoring of antiviral therapeutic efficacy in living mice.
Bankang Ruan   +9 more
wiley   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

open access: yesAdvanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li   +8 more
wiley   +1 more source

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

open access: yesAdvanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei   +10 more
wiley   +1 more source

磁力齿轮-电机复合式电动轮毂驱动特性分析

open access: yesJixie chuandong, 2014
Aiming at investigating the applications of field modulated magnetic gear(FMMG)in electric vehicle drive,firstly,combined with the basic principle of magnetic gear,a new motor combined with the FMMG when it is embedded into the ordinary permanent magnet ...
高广, 曹家勇, 刘洋, 梁庆华
doaj  

Safety of Sodium‐Ion Batteries: Evaluation and Perspective from Component Materials to Cells, Modules, and Packs

open access: yesAdvanced Energy Materials, EarlyView.
This review provides a bottom‐up evaluation of sodium‐ion battery safety, linking material degradation mechanisms, cell engineering parameters, and module/pack assembly. It emphasizes that understanding intrinsic material stability and establishing coordinated engineering control across hierarchical levels are vital for preventing degradation coupling ...
Won‐Gwang Lim   +5 more
wiley   +1 more source

Thermal Runaway Detection Method for Smart Electric Bicycle Charger

open access: yesEngineering Reports
A novel algorithm for thermal runaway detection embedded in the electric bicycle charging system is proposed. The battery's internal temperature is a key indicator to diagnose battery safety and monitor the charging state. First, the relationship between
Jing Ning, Bing Xiao, Wenbin Zhao
doaj   +1 more source

Influence Factor Analysis of Bicycle Free-Flow Speed for Determining the Design Speeds of Separated Bicycle Lanes

open access: yesInformation, 2020
To provide a knowledge basis for updating the design speed in bicycle facility codes, this paper examines factors that influence bicycle free-flow speed.
Xingchen Yan   +4 more
doaj   +1 more source

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