Results 61 to 70 of about 976,567 (240)

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

A Safety Detection Method for Electric Bike Riding Incorporating License Plate Region Recognition

IEEE Access
The widespread use of electric bikes has made rider safety a crucial issue in intelligent transportation research. To address the limitations of existing methods in terms of accuracy and robustness in electric bike license plate recognition, helmet ...
Shaohui Zhong, Xiaofei Liu
doaj   +1 more source

Impacts of Smart Configuration in Pedelec-Sharing: Evidence from a Panel Survey in Madrid

Journal of Advanced Transportation, 2017
Despite the recently increasing research interest, this is one of the first studies employing a panel sample of users and nonusers to understand the bike-sharing phenomenon (N=205). On the basis of a novel surveying technique, a case study on the clients
András Munkácsy, Andrés Monzón
doaj   +1 more source

Early Spatial and Contextual Coding Deficits in Hippocampal CA1 Precede Performance Decline in an Alzheimer's Disease Model

Advanced Science, EarlyView.
Two‐photon calcium imaging in behaving 5xFAD mice reveals early CA1 coding deficits before behavioral decline. Task‐related place cell activity and splitter cell trajectory coding are impaired, with reduced retrospective dominance and greater prospective weighting.
Yimei Li, Mary Ann Go, Hualong Zhang, Robertas Aleksynas, Juliana Kim, Mingyang Gao, Seigfred Prado, Magdalena Sastre, Simon R. Schultz   +8 more
wiley   +1 more source

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

An Overview of Existing Experiences with Solar-Powered E-Bikes

Energies, 2018
Electric bicycles (e-bikes) are considered a sustainable alternative to automobile transportation today. The electric bike includes all the benefits that conventional bicycles offer, plus faster, more comfortable and longer trips, as well as less effort ...
Georgia Apostolou, Angèle Reinders, Karst Geurs   +2 more
doaj   +1 more source

Similarity‐Enhanced Representation Learning of Non‐Canonical Amino Acids for Therapeutic Peptide Modeling

Advanced Science, EarlyView.
Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu, Lesong Wei, Jianmin Wang, Yuanpeng Xiong, Ruochi Zhang, Yu Wang, Chao Zha, Qiangcheng Zeng, Xin Gao   +8 more
wiley   +1 more source

Cycling into the workshop: e-bike and m-bike mobility patterns for predictive maintenance in Barcelona’s bike-sharing system

EPJ Data Science
Bike-sharing systems have emerged as a significant element of urban mobility, providing an environmentally friendly transportation alternative. With the increasing integration of electric bikes alongside mechanical bikes, it is crucial to illuminate ...
Jordi Grau-Escolano, Aleix Bassolas, Julian Vicens   +2 more
doaj   +1 more source

STRIDE Project F3 - Bike Share, Electric-Powered Pedal-Assist Bike Share, and Electric Scooter System Operation

, 2023
<p>STRIDE Project F3 - Bike Share, Electric-Powered Pedal-Assist Bike Share, and Electric Scooter System Operation Data including:</p> <p>1) Birmingham, AL trip counts</p> <p>2) Mobile, AL trip counts</p> <p>3)
Michalaka, Dimitra, Hughey, Morgan, Kweku, Brown, Davis, William, Watkins, Kari   +4 more
core   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source