Results 91 to 100 of about 20,751 (243)

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Clinical studies on incontinence treated by electroacupuncture: a metaanalysis

Huli yanjiu, 2018
Objective:To evaluate the effectiveness of electroacupuncture in the treatment of senile incontinence.Methods:The literatures of randomized controlled trial(RCT)on senile incontinence treated by electroacupuncture were retrieved from PubMed,Web of ...
张嘉鹏, 陈佩仪, 赵子煜
doaj  

GABRB3 Gene Polymorphisms Influences the Analgesic Response to Acupuncture Treatment in Patients With Chronic Knee Pain: A Randomized Controlled Neuroimaging Transcriptomics Study

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Study on KOA chronic knee pain patients shows GABRB3 rs4906902 polymorphism influences acupuncture analgesic efficacy, related to gray matter volume and gene expression in pain‐modulating brain regions. ABSTRACT The mechanisms underlying individual variability in acupuncture analgesia among patients with chronic pain remain unclear.
Sai Wu, Wanxia Wu, Jun Zhou, Shirui Cheng, Xiaohui Dong, Yang Chen, Chenjian Tang, Wenhua He, Fang Zeng, Fanrong Liang, Zhengjie Li   +10 more
wiley   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, Volume 13, Issue 19, 2 April 2026.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Real‐Time and High‐Resolution NIR‐II‐L Imaging of Netrin‐1‐Mediated Neurovascular Coupling Driven by Dose‐Dependent Electroacupuncture

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Disrupted neurovascular coupling contributes to ovarian dysfunction in polycystic ovary syndrome. Using near‑infrared II long‑wavelength imaging, this study visualizes how electroacupuncture dynamically regulates ovarian blood vessels in vivo. Immediate and cumulative stimulation elicit distinct vascular responses via a Netrin‐1 dependent mechanism ...
Yicong Wang, Zi‐Han Chen, Jiajia Li, Wei Hu, Ying Cao, Yu Wang, Xiaoyu Tong, Wenhan Lu, Yuze Yang, Yuehao Wang, Yan Xiao, Wenhao Gao, Yuning Chen, Yuyan Hou, Fan Zhang, Yi Feng   +15 more
wiley   +1 more source

Acupuncture: A Promising Non‐Pharmacological Approach to Parkinson's Disease Management

Brain and Behavior, Volume 16, Issue 4, April 2026.
The mechanism of acupuncture treatment of PD models involves oxidative stress, intestinal flora, neuroinflammation, autophagy, neurogenesis, pyroptosis, and apoptosis. ABSTRACT Purpose This review aims to elucidate the molecular mechanisms underlying the neuroprotective effects of acupuncture in preclinical models of Parkinson's disease (PD).
Xi‐Chen Wu, Yi‐Yue Dong, Yu‐Chen Ying, Ping Yin, Yue‐Lai Chen   +4 more
wiley   +1 more source

Acupuncture Modulates Neurotransmitter‐Related Molecules in the Amygdala to Ameliorate Generalized Anxiety Disorder

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
Acupuncture alleviates anxiety‐like behaviors by modulating functional brain regions and neurotransmitter‐related gene expression. In both human and animal models, this study confirms that acupuncture regulates amygdala activity, offering potential for anxiety management. ABSTRACT Background Neurotransmitter imbalance is a key mechanism contributing to
Zhao Sun, Yixiang Wang, Xiaona Kang, Binyan Ran, Qiong Wu, Luyu Huang, Jiaxin Li, Lina Kan, Haixia Long, Jiabin Liang, Wei Shen   +10 more
wiley   +1 more source

Electroacupuncture Modulates Multiple Pathways for Neuroprotection and Neurorepair in Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
EA exerts therapeutic effects in ischemic stroke through multiple mechanisms: it alleviates acute injury by suppressing neuroinflammation, excitotoxicity, oxidative stress, apoptosis, pyroptosis, ferroptosis, autophagy dysregulation, and blood–brain barrier disruption, while enhancing cerebral blood flow, angiogenesis, and neurogenesis to support ...
Mingyue Zhao, Hangyu Shen, Xu Yan, Xiang Gao, Yuchun Liu, Shengjun Zhou, Jingxian Sun, Jie Sun, Yi Huang   +8 more
wiley   +1 more source

Acupuncture for cancer pain in adults. [PDF]

, 2015
Background: Forty per cent of individuals with early or intermediate stage cancer and 90% with advanced cancer have moderate to severe pain and up to 70% of patients with cancer pain do not receive adequate pain relief.
Alimi, Aung, Bao, Bardia, Beuken-van Everdingen, Beuken-van Everdingen, Brainin-Mattos, Cata, Chao, Chen, Chen, Choi, Coleman, Dang, Dang, Dang, Davis, Derry, Dillon, Ernst, Ernst, Ezzo, Filshie, Filshie, Filshie, Furlan, Garcia, Gralow, Green, Guo, Harding, He, He, Hopwood, Hu, Johnson, Keskinbora, Kwon, Laird, Lee, Lian, Lipton, Liu, Lu, Lund, Lundeberg, Lundeberg, MacPherson, Manheimer, Manheimer, Meng, Minton, Nguyen, Payne, Petrut, Poulain, Qaseem, Ripamonti, Rosier, Strong, Sun, Towler, Trinh, Twycross, Urch, Vallerand, Wang, White, White, Xia, Yu, Zhang   +71 more
core   +1 more source

Astrocytes as central integrators of neural circuit function: Mechanisms and dysregulation in neuropsychiatric disorders

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
1. Astrocytes are central integrators of neural circuit function through tripartite synapse modulation and neurovascular coupling. 2. Dysregulation of glutamate/GABA homeostasis and neuroinflammation represents shared mechanisms across diverse neuropsychiatric disorders. 3.
Xinyu Liu, Xinyue Zhou, Ruotong Meng, Yanxi Chen, You Chen, Blake Highet, Maurice Curtis, Bernhard Hirt, Shunying Yu, Jin Zhou, Linya You   +10 more
wiley   +1 more source