Results 221 to 230 of about 326,761 (272)

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee, Amy‐Lee Richards, Nageswara Reddy, Brian Beers, Lee Golden, Ronald Kong   +5 more
wiley   +1 more source

Photoplethysmography-Based Machine Learning Approaches for Atrial Fibrillation Burden: Algorithm Development and Validation. [PDF]

JMIR Cardio
Wang H, Liu B, Zhang H, Zhang Z, Jin Z, Wang H, Guo YT.   +6 more
europepmc   +1 more source

A Phase 1, Randomized, Placebo‐Controlled, Multiple‐Dose, Double‐Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This Phase 1, randomized, placebo‐controlled, double‐blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1 ...
Rajinder Bhardwaj, Chay Ngee Lim, Yinhua Li, Kyle T. Matschke, Richard Bertz, Robert Croop, Jing Liu   +6 more
wiley   +1 more source

Bidirectional Ventricular Tachycardia Secondary to Dichloromethane Intoxication: A Case Report. [PDF]

Cureus
Sardinha Borborema LH, Adedd Filho DA.
europepmc   +1 more source

Takotsubo Cardiomyopathy Following an Emergent Midline Exploratory Laparotomy: A Case Report. [PDF]

Cureus
Abu Ghazal DA, Khalil AA, Abu Ghazal J, Abu Ghazal MA, Alsayed O.   +4 more
europepmc   +1 more source

Corrigendum to "Comparison of pilot tone-triggered and electrocardiogram-triggered cardiac magnetic resonance imaging: a prospective clinical feasibility study" [J Cardiovasc Magn Reson 27 (2025) 101925]. [PDF]

J Cardiovasc Magn Reson
Qian X, Wu Y, Speier P, Fu C, Wu Y, Cheng L, Chen Y, Wang S, Chen C, Liu K, Chen L, Jin H, Zeng M.   +12 more
europepmc   +1 more source

Effectiveness evaluation of standardized patient training system on emergency department residents in disposing patients with acute chest pain. [PDF]

BMC Med Educ
Lu F, Huang T, Chen R, Wang Y, Yin H.
europepmc   +1 more source