Results 171 to 180 of about 48,655 (256)

Enhanced Clearance of HIV‐1 Broadly Neutralizing Antibody VRC07‐523‐LS During Viremia: Influences on Trial Design and Analysis

open access: yesClinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Broadly neutralizing antibodies (BNAb) are capable of neutralizing multiple HIV‐1 strains through the targeting of conserved epitopes. This study's objective was to quantify the pharmacokinetic (PK) parameters describing the distribution and elimination of the BNAb VRC07‐523‐LS in people with HIV (PWH), and to identify the influence of viral ...
Nicholas M. Smith   +14 more
wiley   +1 more source

Secukinumab in the Treatment of Moderate‐to‐Severe Hidradenitis Suppurativa: Pooled Pharmacokinetics and Safety Results From the SUNSHINE and SUNRISE Phase 3 Studies

open access: yesInternational Journal of Dermatology, Volume 65, Issue 2, Page 289-298, February 2026.
ABSTRACT Background Secukinumab, a fully human, monoclonal antibody targeting interleukin‐17A, is approved for moderate‐to‐severe HS in adults. This study evaluated pharmacokinetics (PK), high‐sensitivity C‐reactive protein (hsCRP) changes, and safety of secukinumab over 52 weeks in SUNSHINE and SUNRISE Phase 3 trials.
Afsaneh Alavi   +13 more
wiley   +1 more source

Inflammatory and Myocardial Biomarker Response Following Pulmonary Vein Isolation: Cryoballoon Versus Balloon‐in‐Basket Pulsed Field Ablation

open access: yesJournal of Cardiovascular Electrophysiology, Volume 37, Issue 2, Page 296-304, February 2026.
ABSTRACT Background Cryoballoon ablation (CB) is a well‐established thermal technique for pulmonary vein isolation (PVI), while balloon‐in‐basket pulsed field ablation (BiB‐PFA) represents a novel non‐thermal alternative. Both single‐shot systems may trigger systemic inflammation and myocardial injury, yet direct comparisons are lacking.
Jan‐Per Wenzel   +9 more
wiley   +1 more source

Plasma Proteome Signature for Leukocyte Telomere Length and Its Link to Abdominal Aortic Aneurysm

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Shorter leukocyte telomere length (LTL) is an aging biomarker and risk factor for aging‐related diseases, including abdominal aortic aneurysm (AAA). This study aimed to identify plasma proteins causally associated with LTL and investigate their roles in linking LTL to AAA. A proteomics analysis was conducted for LTL and a polygenic risk score (
Aixin Li   +15 more
wiley   +1 more source

Ruthenium Complexes in Protein Science: Heading a New Generation of Therapeutic and Analytical Tools

open access: yesAngewandte Chemie, Volume 138, Issue 4, 22 January 2026.
This review presents the latest advances in the development of ruthenium complexes within the field of protein science, highlighting their potential applications in biomedical and bioanalytical fields. Abstract Ruthenium complexes are distinguished by their versatile coordination chemistry, redox behaviors and photochemical properties. In recent years,
Liyan Zhang, Yun Chen, Sylvestre Bonnet
wiley   +2 more sources

Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging [PDF]

open access: yes, 2018
Batrla-Utermann, Richard   +10 more
core   +1 more source

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