Results 81 to 90 of about 48,655 (256)

Thyroid hormone status within the physiological range affects bone mass and density in healthy men at the age of peak bone mass [PDF]

, 2011
Context: The hormonal factors involved in the regulation of peak bone mass (PBM) in men have not been fully investigated. Apart from gonadal steroids and somatotropic hormones, thyroid hormones are known to affect bone maturation and homeostasis and are ...
Fiers, Tom, Goemaere, Stefan, Kaufman, Jean, Lapauw, Bruno, ROEF, GREET, Taes, Youri, Zmierczak, Hans-Georg   +6 more
core   +2 more sources

Serum p‐tau217 Is a Prognostic Indicator of Cognitive Impairment in Idiopathic REM Sleep Behavior Disorder

Annals of Neurology, EarlyView.
Objective Assess the performance of serum phosphorylated tau 217 (p‐tau217) and neurofilament light chain (NfL) in predicting risk of cognitive impairment or phenoconversion to dementia in individuals with iRBD. Methods We measured serum p‐tau217 and NfL levels by electrochemiluminescence across 4 polysomnographically confirmed iRBD cohorts (n = 300 ...
Shijun Yan, Anis Sahoo, Tanja Zerenner, Kenneth Marek, Michael Sommerauer, Wolfgang Oertel, Michele T. Hu, George K. Tofaris   +7 more
wiley   +1 more source

Validation and Suitability Assessment of Multiplex Mesoscale Discovery Immunogenicity Assay for Establishing Serological Signatures Using Vaccinated, Non-Vaccinated and Breakthrough SARS-CoV-2 Infected Cases

Vaccines
Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are multi-targeted and variable over time. Multiplex quantitative serological assays are needed to provide accurate and robust seropositivity data for the establishment of
Sushant Shengule, Shweta Alai, Sachin Bhandare, Sumant Patil, Manish Gautam, Bhushan Mangaonkar, Sumit Gupta, Umesh Shaligram, Sunil Gairola   +8 more
doaj   +1 more source

Novel Detection of Acrylamide by Electrochemiluminescence Sensor and Optical Imaging Analysis

International Journal of Electrochemical Science, 2019
Acrylamide, a carcinogen with debilitating effects on human health, was detected by electrochemiluminescence (ECL) measurement using Ru(bpy)32+ as the luminophore.
Xin Yang, Peng Pan, Li Tu, Zhenyu Liao, Huimin Niu, Chuanlai Zang, Mingchen Li, Jun Liu, Zhengchun Yang, Yangyang Qi, Jun Wei, Kwok Wei Shah   +11 more
doaj   +1 more source

Population pharmacokinetics and exposure–response analysis of durvalumab in patients with resectable stage II to IIIB (N2) NSCLC in the phase III AEGEAN study

British Journal of Clinical Pharmacology, EarlyView.
Aims In the AEGEAN study, perioperative durvalumab plus platinum‐based neoadjuvant chemotherapy for patients with resectable stage II to IIIB (N2) non‐small‐cell lung cancer (NSCLC) demonstrated a favourable benefit–risk profile. This study evaluated population pharmacokinetics (PopPK) and exposure–response (ER) relationships of durvalumab in patients ...
Xiaoying Zhao, Junjie Ding, Jiajia Zhao, Ling Zhang, Aburough Abegesah, Yu‐qian Zhang, Cathy O'Brien, Gary J. Doherty, Allen C. Chen, KyoungSoo Lim, Song Ren, Peiming Ma, Diansong Zhou   +12 more
wiley   +1 more source

Ru@NiMoS aggregate with boosted electrochemical catalysis for enhanced electrochemiluminescence and lidocaine detection

Smart Molecules
A binder‐free Ru@NiMoS electrode was engineered by in situ growth of two‐dimensional NiMoS nanosheets on nickel foam. This process effectively promoted the electrostatic‐driven aggregation of Ru(bpy)32+, harnessing the synergistic effect to enhance ...
Yongzhuang Lu, Haoran Wang, Qiyao Li, Qian Liu, Xiaoxu Zhang, Yuying Jia, Xiangyu Cai, Zheng Zhao, Yanfu Huan, Ben Zhong Tang   +9 more
doaj   +1 more source

Montmorency cherries reduce the oxidative stress and inflammatory responses to repeated days high-intensity stochastic cycling [PDF]

, 2014
This investigation examined the impact of Montmorency tart cherry concentrate (MC) on physiological indices of oxidative stress, inflammation and muscle damage across 3 days simulated road cycle racing.
Alessio, Bitsch, Delgado, Emma Stevenson, Felgines, Fossati, Gareth Davison, Girotti, Glyn Howatson, Goldfarb, Ian Walshe, Kelley, Phillip Bell, Phillips, Sies, Starkie   +15 more
core   +2 more sources

Calcium retinoate nanoparticle mediated microglial polarization to regulate inflammatory microenvironment for therapy of neuroinflammatory disease

BMEMat, EarlyView.
A nano‐drug based on retinoic acid and calcium is developed, which can be rapily endocytosed by microglia and decomposed into small molecule/ion storms in lysosomes. This nano‐drug regulates microglial phenotype switching from M1 to M2 while indirectly guiding neuronal differentiation of endogenous neural stem cells, thereby ameliorating ...
Shuo Zhang, Yuan Yao, Wenfeng Shao, Jiapei Shi, Benjie Wei, Chunhui Sun, Jingang Wang, Jiaming Shi, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Na Ren, Yuchun Tang, Wenjuan Zhou, Shuping Wang   +13 more
wiley   +1 more source

Avaliação comparativa de dosagem do marcador tumoral CA 15-3 em cadelas hígidas ou com neoplasia mamária

Pesquisa Veterinária Brasileira
RESUMO: O antígeno CA 15-3 é uma proteína presente no soro utilizado no acompanhamento de mulheres com câncer de mama, essencialmente na detecção de metástases.
Gabriela B. Roberto, Liane Ziliotto, Meire Christina Seki   +2 more
doaj   +1 more source

Ground and excited state communication within a ruthenium containing benzimidazole metallopolymer [PDF]

, 2011
Emission spectroscopy and electrochemistry has been used to probe the electronic communication between adjacent metal centres and the conjugated backbone within a family of imidazole based metallopolymer, [Ru(bpy)2(PPyBBIM)n]2+, in the ground and excited
Blakely, Cameron, Cameron, Crawford, Dahms, Darren Griffith, Dennany, Dennany, Dennany, Dennany, Dennany, Dennany, Doherty, Emmet J. O'Reilly, Forster, Francois Moser, Haas, Hogan, Holiday, Jr. Arnold, Kaneko, Kasha, Keyes, Kingsborough, Kurashina, Lynn Dennany, Lyons, McClean, Mortimer, Nishihara, O'Mullane, Ofer, Osaheni, Paul, Rehm, Robert J. Forster, Roberts, Ruff, Shardon-Noblat, Terrill, Thackeray, Tia E. Keyes, Venkatanarayanan, Vogel, Wuelfing, Xing, Zhu, Ziessel   +47 more
core   +1 more source