Results 91 to 100 of about 8,312,375 (325)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Electron-electron interactions and two-dimensional - two-dimensional tunneling

, 1996
We derive and evaluate expressions for the dc tunneling conductance between interacting two-dimensional electron systems at non-zero temperature. The possibility of using the dependence of the tunneling conductance on voltage and temperature to determine
A. H. MacDonald, A. V. Chaplik, A.-P. Jauho, A.H. MacDonald, C. Hodges, C.A. Kukkonen, C.S. Ting, D. Rogovin, D.M. Ceperley, D.R. Penn, F. Giuliani, F. Stern, G. Vignale, G.D. Mahan, G.F. Giuliani, H. Fukuyama, H.C. Tso, J. Smoliner, J.F. Janak, J.P. Eisenstein, J.P. Eisenstein, J.P. Eisenstein, K. Flensberg, L. Zheng, L. Zheng, P.F. Maldague, P.J. Price, S. Das Sarma, S. Moroni, S. Yarlagadda, S.Q. Murphy, T. Jungwirth, T.J. Gramila, T.J. Gramila, U. Sivan, X. Zhu   +35 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Enamel Surface and Elemental Changes Following In Vitro Bleaching: A SEM-EDS Approach

Dentistry Journal
Background and Objectives: Chairside bleaching can alter enamel morphology and mineral content. This in vitro study compared surface changes and elemental shifts after three in-office protocols using scanning electron microscopy (SEM) and energy ...
Berivan Laura Rebeca Buzatu, Ramona Dumitrescu, Magda Mihaela Luca, Roxana Buzatu, Atena Galuscan, Vanessa Bolchis, Gabriela Vlase, Titus Vlase, Daniela Elisabeta Jumanca   +8 more
doaj   +1 more source

OVERVIEW OF X-RAY FLUORESCENCE SPECTROMETRY [PDF]

Fiabilitate şi Durabilitate, 2021
One of the techniques used in identifying the constituent chemical elements of a material is the X-ray fluorescence method. From the analysis of X-ray fluorescence data the energy and intensity of the characteristic photons emitted by the sample can be
Nicoleta-Maria MIHUȚ, Cătălina IANĂȘI   +1 more
doaj  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Polarization phenomena initiated by electromagnetic interactions of particles with nuclei [PDF]

Ядерна фізика та енергетика, 2010
Polarization phenomena in the processes induced by electromagnetic interaction of photons, electrons, nucleons and certain composite particles with nuclei are studied.
V. K. Tartakovsky
doaj  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Electron-Electron Bremsstrahlung Emission and the Inference of Electron Flux Spectra in Solar Flares

, 2007
Although both electron-ion and electron-electron bremsstrahlung contribute to the hard X-ray emission from solar flares, the latter is normally ignored.
A. Gordon Emslie, Anna Maria Massone, Eduard P. Kontar, Haug E., Haug E., John C. Brown, Marco Prato, Michele Piana, Trottet G.   +8 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source