Results 51 to 60 of about 6,093,819 (293)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Laser Wakefield Electron Acceleration in a Periodically Modulated Plasma Density Profile

Plasma
We investigate laser wakefield electron acceleration in a periodic plasma density profile using 2D PIC simulations with the EPOCH code. The profile of the electron density has the form n(x)=n01+δsin2πx/x0, where n0 is the steady electron density, x0=100m
Rareș Iovănescu, Radu P. Daia, Anana C. Gîrlea, Emil I. Slușanschi, Cătălin M. Ticoș   +4 more
doaj   +1 more source

A Study of the Ionospheric Electron Measurement on the Medium-sized Scientific Rocket, KSR-II [PDF]

Journal of Astronomy and Space Sciences, 1998
This paper reports the results obtained from the Langmuir probe (LP) and Electron Temperature Probe (ETP) experiments on the sounding rocket KSR-II (Korean Scientific Rocket - II) which was launched on Jun 11, 1998 at 10:00 KST from Tae-An peninsula (37 ...
Jae-Jin Lee, Jhoon Kim, Soo-Jin Lee, Kyoung-Wook Min, You Surn Pyo, Gwang Rae Cho, Hwang-Jae Rhee   +6 more
doaj  

Self-consistent modelling of the daytime electron density profile in the ionospheric F region [PDF]

Annales Geophysicae, 1997
A theoretical self-consistent method for the description of daytime Ne(h) profiles in the ionospheric F region measured by EISCAT is proposed. It is based on the use of a theoretical F-region model and measured electron density, Ne(h), electron, Te(h)
A. Mikhailov, A. Mikhailov, K. Schlegel
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Mechanisms to control laser-plasma coupling in laser wakefield electron acceleration

Physical Review Accelerators and Beams, 2022
Experimental results, supported by precise modeling, demonstrate optimization of a plasma-based injector with intermediate laser pulse energy (
L. T. Dickson, C. I. D. Underwood, F. Filippi, R. J. Shalloo, J. Björklund Svensson, D. Guénot, K. Svendsen, I. Moulanier, S. Dobosz Dufrénoy, C. D. Murphy, N. C. Lopes, P. P. Rajeev, Z. Najmudin, G. Cantono, A. Persson, O. Lundh, G. Maynard, M. J. V. Streeter, B. Cros   +18 more
doaj   +1 more source

Influence of sintering temperature and pressure on crystallite size and lattice defect structure in nanocrystalline SiC [PDF]

, 2007
Microstructure of sintered nanocrystalline SiC is studied by x-ray line profile analysis and transmission electron microscopy. The lattice defect structure and the crystallite size are determined as a function of pressure between 2 and 5.5 GPa for ...
T. Ungár, Nauyoks, S., Gubicza, Jenő, Lábár, János, L. Balogh, Zerda, T. W., J. Gubicza, Balogh, Levente, Ungár, Tamás, S. Nauyoks, T.W. Zerda, J. Labar   +11 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Radio occultation techniques for probing the ionosphere

Annals of Geophysics, 2004
GPS radio occultation measurements establish the basis for a new remote sensing technique for vertical profile information on the electron density of the entire ionosphere from satellite orbit heights down to the bottomside.
M. Angling, R. Leitinger, N. Jakowski
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source