Results 41 to 50 of about 847,944 (321)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Femtosecond gas-phase mega-electron-volt ultrafast electron diffraction

Structural Dynamics, 2019
The development of ultrafast gas electron diffraction with nonrelativistic electrons has enabled the determination of molecular structures with atomic spatial resolution.
X. Shen, J. P. F. Nunes, J. Yang, R. K. Jobe, R. K. Li, Ming-Fu Lin, B. Moore, M. Niebuhr, S. P. Weathersby, T. J. A. Wolf, C. Yoneda, Markus Guehr, Martin Centurion, X. J. Wang   +13 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Double-shot MeV electron diffraction and microscopy

Structural Dynamics, 2017
In this paper, we study by numerical simulations a time-resolved MeV electron scattering mode where two consecutive electron pulses are used to capture the evolution of a material sample on 10 ps time scales.
P. Musumeci, D. Cesar, J. Maxson
doaj   +1 more source

Structural dynamics of surfaces by ultrafast electron crystallography: Experimental and multiple scattering theory [PDF]

, 2011
Recent studies in ultrafast electron crystallography (UEC) using a reflection diffraction geometry have enabled the investigation of a wide range of phenomena on the femtosecond and picosecond time scales.
Liang, Wenxi, Schäfer, Sascha, Zewail, Ahmed H.   +2 more
core   +1 more source

Hollow Electron Ptychographic Diffractive Imaging [PDF]

Physical Review Letters, 2018
We report a method for quantitative phase recovery and simultaneous electron energy loss spectroscopy analysis using ptychographic reconstruction of a data set of "hollow" diffraction patterns. This has the potential for recovering both structural and chemical information at atomic resolution with a new generation of detectors.
Song, B, Ding, Z, Allen, C, Sawada, H, Zhang, F, Pan, X, Warner, J, Kirkland, A, Wang, P   +8 more
openaire   +3 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Angle-Resolved Time-of-Flight Electron Spectrometer Designed for Femtosecond Laser-Assisted Electron Scattering and Diffraction

Instruments, 2023
We developed an apparatus for measuring kinetic energy and two-dimensional angular distributions of femtosecond laser-assisted electron scattering (LAES) signals with a high detection efficiency, consisting of a photocathode-type ultrashort pulsed ...
Motoki Ishikawa, Kakuta Ishida, Reika Kanya, Kaoru Yamanouchi   +3 more
doaj   +1 more source

Structure elucidation of polyheptazine imide by electron diffraction — a templated 2D carbon nitride networkw [PDF]

, 2009
Structure elucidation of a condensed carbon IV) nitride with a stoichiometry close to C3N4 by electron diffraction reveals a two-dimensional planar heptazine-based network containing isolated melamine molecules in the trigonal ...
Döblinger, Markus, Lotsch, Bettina V., Schnick, Wolfgang, Senker, Jürgen, Thun, Jürgen, Wack, Julia   +5 more
core   +1 more source