Results 91 to 100 of about 7,750,015 (291)

Exploration on natural bond orbitals, molecular electrostatic potential, drug likeness and Ramachandran plot of diethyl 3-hydroxyglutarate (C9H16O5): A potential ingredient for cancer treatment

Next Materials
The ester derivative of 3-hydroxyglutaric acid, diethyl 3-hydroxyglutarate (DE 3-HG; C9H16O5), has shown promise in the search for new anticancer drugs because of its structural resemblance to α-ketoglutarate and ability to interfere with tumor ...
M. Lawrence, C. Prabhu, Immaculate A. Geetha Anthappa, S. Sahaya Jude Dhas, Mohammed T. Alotaibi   +4 more
doaj   +1 more source

Localization-delocalization transition in one-dimensional electron systems with long-range correlated disorder [PDF]

, 2004
We investigate localization properties of electron eigenstates in one-dimensional (1D) systems with long-range correlated diagonal disorder. Numerical studies on the localization length ξ of eigenstates demonstrate the existence of the localization ...
Shima, H., Nakayama, T., Nomura, T., 島, 弘幸   +3 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain

eLife, 2017
Protein kinase A (PKA) plays critical roles in neuronal function that are mediated by different regulatory (R) subunits. Deficiency in either the RIβ or the RIIβ subunit results in distinct neuronal phenotypes.
Ronit Ilouz, Varda Lev-Ram, Eric A Bushong, Travis L Stiles, Dinorah Friedmann-Morvinski, Christopher Douglas, Jeffrey L Goldberg, Mark H Ellisman, Susan S Taylor   +8 more
doaj   +1 more source

Chromosome Centromeres: Structural and Analytical Investigations with High Resolution Scanning Electron Microscopy in Combination with Focused Ion Beam Milling [PDF]

, 2009
Whole mount mitotic metaphase chromosomes of different plants and animals were investigated with high resolution field emission scanning electron microscopy (FESEM) to study the ultrastructural organization of centromeres, including metacentric ...
Schroeder-Reiter, E., Wanner, Gerhard
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Josephson effect in strongly disordered metallic wires

SciPost Physics
We study localization effects in Josephson junctions with two superconductors connected by a strongly disordered metallic wire of length $L$. The conventional description of the Josephson effect in such systems, based on the quasiclassical Usadel ...
Mustafa E. Ismagambetov, Aleksey V. Lunkin, Pavel M. Ostrovsky
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

First-principles study of MXene properties with varying hydrofluoric acid concentration

iScience
Summary: With varying hydrofluoric acid (HF) concentrations under three etching conditions, we presented a comparative study of the effects of both the ordered and randomly ternary mixed terminated Ti3C2Tx surfaces with a wide variation of O/OH/F ...
Yi Zhi Chu, Megan Hoover, Patrick Ward, Kah Chun Lau   +3 more
doaj   +1 more source

Electron energy spectrum and oscillator strengths of quantum transitions in double quantum ring nanostructure driven by electric field

Condensed Matter Physics, 2018
The effect of homogeneous electric field on the energy spectrum, wave functions of electron and oscillator strengths of intra-band quantum transitions in a double cylindrical quantum ring (GaAs/Al_{x}Ga_{1-x}As) is studied within the approximations of ...
O.M. Makhanets, V.I. Gutsul, A.I. Kuchak
doaj   +1 more source