Utilizing MEDT analysis of [3 + 2] cycloaddition reaction: x-ray crystallography of spirooxindole linked with thiophene/furan heterocycles and triazole framework [PDF]
BMC ChemistryHybridization of spirooxindole with different pharmacophores such as triazole and heterocycle such as thiophene and furan moiety was achieved by the [3 + 2] cycloaddition (32CA) reaction approach. Structural investigations of the compounds 4a and 4b were
Abdulmajeed Abdullah Alayyaf +7 more
doaj +5 more sources
A cross-sectional survey on depersonalization/derealization and meditation-induced alterations of the self [PDF]
Scientific ReportsDepersonalization/derealization (DPDR) involves feeling detached from one’s body, thoughts, or emotions and is often triggered by trauma, stress, mental health issues, or drug use, typically causing high distress. Similar experiences are also reported in
Erola Pons +3 more
doaj +2 more sources
Novel multi-task learning for Alzheimer’s stage classification using hippocampal MRI segmentation, feature fusion, and nomogram modeling [PDF]
European Journal of Medical ResearchObjective To develop and validate a comprehensive and interpretable framework for multi-class classification of Alzheimer’s disease (AD) progression stages based on hippocampal MRI, integrating radiomic, deep, and clinical features. Materials and methods
Wenqi Hu +4 more
doaj +2 more sources
Subcortical gray matter aging and attentional control in amateur musicians and nonmusicians. [PDF]
Ann N Y Acad Sci108 adults aged 20 to 88 years were recruited, including 34 singers, 37 instrumentalists, and 37 active nonmusicians. Participants completed an auditory selective attention task and a visual inhibition task. MRI images were acquired to examine the relationship between subcortical volumes and attention in these groups.
Sicard A, Tremblay P.
europepmc +2 more sources
Enhancing Antimicrobial Susceptibility Testing for Acinetobacter baumannii Using Physiologically Relevant Culture Media and Biofilm Formation Assays. [PDF]
Curr ProtocAbstract Acinetobacter baumannii is a high‐risk pathogen associated with increased patient morbidity and mortality. Host‐pathogen interactions amplify its virulence, in part by promoting biofilm formation—a crucial factor in antimicrobial resistance and persistence.
Sakyi Opoku NYP +4 more
europepmc +2 more sources
Molecules, 2023 A new series of spirooxindoles based on benzimidazole, triazole, and isatin moieties were synthesized via a [3+2] cycloaddition reaction protocol in one step. The single X-ray crystal structure of the intermediate triazole-benzimidazole 4 was solved. The
Mar Rios-Gutierrez +2 more
exaly +3 more sources
Intramolecular Versus Intermolecular Diels–Alder Reactions: Insights from Molecular Electron Density Theory [PDF]
MoleculesThe intramolecular Diels–Alder (IMDA) reactions of four substituted deca-1,3,9-trienes and one N-methyleneocta-5,7-dien-1-aminium with different electrophilic/nucleophilic activations have been studied within the Molecular Electron Density Theory (MEDT ...
Luis R. Domingo, Patricia Pérez
doaj +2 more sources
Enhancing Deep Learning-Based Subabdominal MR Image Segmentation During Rectal Cancer Treatment: Exploiting Multiscale Feature Pyramid Network and Bidirectional Cross-Attention Mechanism. [PDF]
Int J Biomed ImagingBackground: This study is aimed at solving the misalignment and semantic gap caused by multiple convolutional and pooling operations in U‐Net while segmenting subabdominal MR images during rectal cancer treatment. Methods: We propose a new approach for MR Image Segmentation based on a multiscale feature pyramid network and a bidirectional cross ...
Xiao Y, Yang X, Huang S, Guo L.
europepmc +2 more sources
Experimental and MEDT Study of Sydnone–Alkyne Cycloaddition-Based Synthesis of 1,4-Disubstituted Pyrazoles and In Silico Investigation of Their Binding to HCV and HIV Proteins [PDF]
MoleculesSix 1,4-disubstituted pyrazoles linked to a benzenesulfonamide and a benzodioxane unit have been synthesized through a copper(I)-catalyzed formal [3+2] cycloaddition (32CA) reaction of alkynes with 3-arylsydnones.
Souad Zerbib +9 more
doaj +2 more sources
Computational study of the mechanism and selectivity of [3 + 2] cycloaddition reactions between nitrone and carbodiimide leading to the formation of anticancer 1,2,4-oxadiazolidine compounds from a MEDT perspective [PDF]
Scientific ReportsThis study explores the reactivity and pharmaceutical potential of a novel anticancer compound, 1,2,4-oxadiazolidine, synthesized through the [3 + 2] cycloaddition (32CA) reaction between nitrone (1a) and carbodiimide (2a).
Moulay Driss Mellaoui +7 more
doaj +2 more sources