Development of variously functionalized nitrile oxides [PDF]
Beilstein Journal of Organic Chemistry, 2015 N-Methylated amides (N,4-dimethylbenzamide and N-methylcyclohexanecarboxamide) were systematically subjected to chemical transformations, namely, N-tosylation followed by nucleophilic substitution.
Haruyasu Asahara +2 more
doaj +7 more sources
Azirinyl-Substituted Nitrile Oxides: Generation and Use in the Synthesis of Isoxazole Containing Heterocyclic Hybrids [PDF]
MoleculesThe procedure for the generation of azirinyl-substituted nitrile oxides by the reaction of 2-(diazoacetyl)-2H-azirines with tert-butyl nitrite while preserving the azirine ring has been developed.
Alexander S. Dudik +4 more
doaj +3 more sources
Synthesis of 3,4,5-trisubstituted isoxazoles in water via a [3 + 2]-cycloaddition of nitrile oxides and 1,3-diketones, β-ketoesters, or β-ketoamides [PDF]
Beilstein Journal of Organic Chemistry, 2022 Herein we report a method for the synthesis of 3,4,5-trisubstituted isoxazoles in water under mild basic conditions at room temperature via a [3 + 2]-cycloaddition of nitrile oxides and 1,3-diketones, β-ketoesters, or β-ketoamides.
Md Imran Hossain +3 more
doaj +2 more sources
Fluorescent Probes from Aromatic Polycyclic Nitrile Oxides: Isoxazoles versus Dihydro‐1λ3,3,2λ4‐Oxazaborinines [PDF]
ChemistryOpen, 2019 Anthracenenitrile oxide undergoes 1,3‐dipolar cycloaddition reaction with propargyl bromide affording the expected isoxazole as single regioisomer, suitably synthetically elaborated and functionalized with a protected triple bond.
Dr. Mattia Moiola +7 more
doaj +2 more sources
Facile synthesis of hydantoin/1,2,4-oxadiazoline spiro-compounds via 1,3-dipolar cycloaddition of nitrile oxides to 5-iminohydantoins [PDF]
Beilstein Journal of Organic ChemistryThe cycloaddition of 1,3-dipoles at C=N bonds is a relatively rare process, in contrast to the widespread cycloaddition reactions at C=C, C≡C, and C=S bonds.
Juliana V. Petrova +6 more
doaj +2 more sources
Reaction of Nitrilimines and Nitrile Oxides with Hydrazines, Hydrazones and Oximes
Molecules, 2005 This review article discusses the reaction of nitrilimines and nitrile oxides with hydrazines, hydrazones, and oximes. Three reaction modes were observed.
Adel M Awadallah
exaly +3 more sources
The Puzzle of the Regioselectivity and Molecular Mechanism of the (3+2) Cycloaddition Reaction Between E-2-(Trimethylsilyl)-1-Nitroethene and Arylonitrile N-Oxides: Molecular Electron Density Theory (MEDT) Quantumchemical Study [PDF]
MoleculesThe regioselectivity and molecular mechanism of the (3+2) cycloaddition reaction between E-2-(trimethylsilyl)-1-nitroethene and arylonitrile N-oxides were explored on the basis of the ωB97XD/6-311+G(d) (PCM) quantumchemical calculations.
Mikołaj Sadowski +2 more
doaj +2 more sources
Combined experimental and theoretical studies of regio- and stereoselectivity in reactions of β-isoxazolyl- and β-imidazolyl enamines with nitrile oxides [PDF]
Beilstein Journal of Organic Chemistry, 2016 Reactions of β-azolyl enamines and nitrile oxides were studied by both experimental and theoretical methods. (E)-β-(4-Nitroimidazol-5-yl), (5-nitroimidazol-4-yl) and isoxazol-5-yl enamines smoothly react regioselectively at room temperature in dioxane ...
Ilya V. Efimov +10 more
doaj +2 more sources
Scope and Limitations of Boron Fluorescent Complexes from Stable Nitrile Oxides in ABPP Assays [PDF]
ACS Omega, 2019 Mattia Moiola +6 more
doaj +2 more sources
Pharmacochemical Studies of Synthesized Coumarin–Isoxazole–Pyridine Hybrids [PDF]
MoleculesSeveral new coumarin–isoxazole–pyridine hybrids were synthesized through a 1,3-dipolar cycloaddition reaction of nitrile oxides, prepared in situ from pyridine aldehyde oximes, with propargyloxy- or propargylaminocoumarins in moderate-to-good yields ...
Matina D. Douka +5 more
doaj +2 more sources