Results 1 to 10 of about 8,655 (241)

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Pharmaceuticals, 2023
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates.
Pan Xinhui
exaly   +4 more sources

Studies of the Synthesis of Fused Isoxazoline/Isoquinolinones and Evaluation of the Antifungal Activity of Isoxazole-like Benzamide and Isoquinolinone Hybrids [PDF]

Molecules
Isoxazole derivatives (isoxazoles, isoxazolines, and isoxazolidines) are present in the structure of several natural products and/or pharmaceutically interesting compounds.
Konstantinos A. Ouzounthanasis, Jasmina Glamočlija, Ana Ćirić, Alexandros E. Koumbis   +3 more
doaj   +3 more sources

Novel Quinazolinone–Isoxazoline Hybrids: Synthesis, Spectroscopic Characterization, and DFT Mechanistic Study

Chemistry, 2022
Quinazolinone and isoxazoline systems have attracted much attention due to their interesting pharmacological properties. The association of these two pharmacophores in a single hybrid structure can boost the biological activity or bring a new one ...
Mohamed El Yazidi, Akhazzane Mohamed, Mohammed Chalkha   +2 more
exaly   +4 more sources

Biocatalytic Synthesis of Isoxazolines Enabled by Cryptic Nitrile Oxide Formation by a Vanadium-Dependent Chloroperoxidase. [PDF]

Angew Chem Int Ed Engl
The vanadium‐dependent haloperoxidase (VHPO) class of enzymes has been shown to catalyze cryptic nitrile oxide generation in an oxidative [3+2] cycloaddition reaction between aldoximes and alkenes to generate isoxazolines. This biotechnology has been applied to a chemoenzymatic sequence starting from aldehydes through in situ condensation with ...
Sharma M, Biegasiewicz KF.
europepmc   +3 more sources

Discovery of a Novel Class of Acylthiourea-Containing Isoxazoline Insecticides against Plutella xylostella

Molecules, 2023
Isoxazoline structures are widely found in natural products and are rich in biological activities. This study discloses the development of a series of novel isoxazoline derivatives by introducing acylthiourea fragments to access insecticidal activity ...
Fangyi Li, Biaobiao Jiang, Yuqin Luo, Siqi He, Di Feng, Deyu Hu, Runjiang Song   +6 more
doaj   +2 more sources

Synthesis of novel 1,2,4-oxadiazole-isoxazoline hybrids and their in silico potential with adenosine receptors [PDF]

Beilstein Journal of Organic Chemistry
A concise and efficient synthetic route to novel 1,2,4-oxadiazole-isoxazoline hybrids 7 has been developed via regioselective 1,3-dipolar cycloaddition of in situ-generated nitrile oxides with 3-(p-substituted-aryl)-5-vinyl-1,2,4-oxadiazoles 6.
Pshtiwan S. Mohammed, Mohammed K. S. Dalo, Onur C. Yazıcı, Muhammet Yildirim, Akın Sağırlı   +4 more
doaj   +2 more sources

A novel method for the determination of isoxazoline derivatives in plasma by ultra-high performance liquid chromatography–tandem mass spectrometry: validation and applicability to screening tests [PDF]

Journal of Veterinary Research
Isoxazoline derivatives such as fluralaner, sarolaner, lotilaner, and afoxolaner are a new class of insecticide and acaricide compounds. These compounds are characterised by rapid action and high efficacy over a period of up to several weeks.
Markowska-Buńka Paulina, Jaroszewski Jerzy J., Rasiński Bartosz, Ziółkowski Hubert   +3 more
doaj   +2 more sources

Functional Characterization of the Cat and Dog Wild-Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany. [PDF]

J Vet Pharmacol Ther
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Siegl L, Bethäuser M, Nürnberger D, Oswald S, Moritz A, Hamann M, Geyer J.   +6 more
europepmc   +2 more sources

Evaluation of efficacy and pharmacokinetics of novel fluralaner tablet formulation (WellPet™) in dogs [PDF]

Frontiers in Veterinary Science
The increasing use of isoxazolines represents a major trend in the control of ectoparasites in companion animals. WellPet™ (Ourofino Saúde Animal Ltd., Brazil) is a newly developed, highly palatable oral tablet containing fluralaner.
Breno Cayeiro Cruz, Marina Belucci Teixeira, Marina Belucci Teixeira, Gessica Ariane de Melo Cruz, Juliana Aparecida do Carmo Emidio Moreira da Silva, Milenni Garcia Michels, Caroline Della Nina Pistoni, Marcus Antonio Martins Buso, Ferdinando Nielsen de Almeida, Igor Renan Honorato Gatto   +9 more
doaj   +2 more sources

Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Reduction in clinical cases of vector-borne diseases is strongly dependent on the ability to reduce the number of infectious insect bites.
Arnab Chatterjee, Marie Miglianico, Constantianus Koenraadt   +2 more
exaly   +2 more sources