Results 1 to 10 of about 3,701 (179)

Regioselective approach to 5-arylsulfonylisoxazoles and their antimicrobial activity [PDF]

Beilstein Journal of Organic Chemistry
This study presents a novel regioselective synthesis of 3-electron-withdrawing-group-(EWG)-substituted 5-sulfonyl- and 5-sulfinylisoxazoles from 3-EWG-5-nitroisoxazoles via nucleophilic aromatic substitution with thiophenols followed by oxidation with m ...
Artem S. Sazonov, Dmitry A. Vasilenko, Denis V. Porfiriev, Yuri K. Grishin, Rimma A. Gazzaeva, Alisa P. Chernyshova, Maxim A. Kryakvin, Anna A. Baranova, Vera A. Alferova, Elena B. Averina   +9 more
doaj   +2 more sources

Synthesis of Some Fused Pyrazoles and Isoxazoles

Molecules, 2000
The α-keto methylene group in 3,5-diaryl-2-cyclohexenones 2 and 3,5-diarylcyclohexanones 8 have been used to obtain fused pyrazoles and isoxazoles. The new compounds were characterized by IR and 1H-NMR spectral data.
Venkatapuram Padmavathi
exaly   +3 more sources

Divergent photochemical ring-replacement of isoxazoles [PDF]

Nature Communications
Isoxazoles, oxazoles, and other five-membered heteroaromatics are prevalent motifs in core structure of pharmaceuticals and agrochemicals. In early-stage drug discovery, it is common practice to prepare libraries of analogues featuring different ...
Yan Xu, Lorenzo Poletti, Enrique M. Arpa, Baptiste Roure, Alessandro Ruffoni, Daniele Leonori   +5 more
doaj   +2 more sources

Azirinyl-Substituted Nitrile Oxides: Generation and Use in the Synthesis of Isoxazole Containing Heterocyclic Hybrids [PDF]

Molecules
The procedure for the generation of azirinyl-substituted nitrile oxides by the reaction of 2-(diazoacetyl)-2H-azirines with tert-butyl nitrite while preserving the azirine ring has been developed.
Alexander S. Dudik, Timur O. Zanakhov, Ekaterina E. Galenko, Mikhail S. Novikov, Alexander F. Khlebnikov   +4 more
doaj   +2 more sources

Synthesis of 2H-azirine-2,2-dicarboxylic acids and their derivatives [PDF]

Beilstein Journal of Organic Chemistry
Methods for the preparation of 3-aryl-2H-azirine-2,2-dicarboxylic acids and their amides, esters, and azides by FeCl2-catalyzed isomerization of 3-aryl-5-chloroisoxazole-4-carbonyl chlorides into 3-aryl-2H-azirine-2,2-dicarbonyl dichlorides followed by ...
Anastasiya V. Agafonova, Mikhail S. Novikov, Alexander F. Khlebnikov   +2 more
doaj   +2 more sources

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Pharmaceuticals, 2023
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates.
Xiyue Wang, Qingyun Hu, Hui Tang, Xinhui Pan   +3 more
doaj   +1 more source

Synthesis of 3,4,5-trisubstituted isoxazoles in water via a [3 + 2]-cycloaddition of nitrile oxides and 1,3-diketones, β-ketoesters, or β-ketoamides

Beilstein Journal of Organic Chemistry, 2022
Herein we report a method for the synthesis of 3,4,5-trisubstituted isoxazoles in water under mild basic conditions at room temperature via a [3 + 2]-cycloaddition of nitrile oxides and 1,3-diketones, β-ketoesters, or β-ketoamides.
Md Imran Hossain, Md Imdadul H. Khan, Seong Jong Kim, Hoang V. Le   +3 more
doaj   +1 more source

Design, Synthesis, and Biological Assessment of Novel Vanillin-Isoxazole Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptor

Chemistry Proceedings, 2023
The homomeric α7 nicotinic acetylcholine receptor (α7 nAChR) is a cation-permeable pentameric ligand-gated channel present in the nervous system and non-neuronal cells.
Santiago Stabile, Juan Facundo Chrestia, Gabriel Radivoy, Cecilia Bouzat   +3 more
doaj   +1 more source

Simple Access to Isoxazole-Containing Heterocyclic Hybrids: Isoxazole/Oxazole and Isoxazole/Pyridine

Russian Journal of General Chemistry, 2023
Abstract The synthesis of substituted isoxazole–oxazole hybrids by the noncatalytic reaction of methyl 2-diazo-2-(alkyl/aryl/hetarylisoxazol-5-yl)acetates with alkyl and aryl cyanides has been reported. According to DFT calculations, the reaction proceeds through the intermediate formation
A. E. Taishev, E. E. Galenko, M. S. Novikov, A. F. Khlebnikov   +3 more
openaire   +1 more source

MnVI-NP–Catalyzed Generation of Nitrile Oxides: Easy Access to Isoxazolines and Isoxazoles via Stereoselective 1,3-Dipolar Cyclo­addition Reactions

SynOpen, 2022
The versatility and effectiveness of MnVI-NPs as a catalyst is examined for the generation of nitrile oxides from aldoximes and subsequent 1,3-dipolar cycloaddition reactions.
Yasmin Saima, Saikat Khamarui
doaj   +1 more source