Results 31 to 40 of about 3,701 (179)

Design, Synthesis and Biological Activity of Regioisomeric 3,5-Disubstituted Isoxazoles and 5-(Hydroxy)Isoxazolines with Aryl and Either (Diterpenylfuran-2-Carbonyl) or (Methylfuran-2-Carbonyl) Moiety

Scientia Pharmaceutica
Alkyn-1,2-diones have gained great attention as useful building blocks in organic synthesis. Regioselective synthetic routes towards 3,5-disubstituted isoxazoles, containing the methylfuroyl or diterpenylfuroyl moiety at the C-3 or C-5 position from ...
Maksim E. Mironov, Dmitry S. Baev, Mohammad S. Hamad, Sergey A. Borisov, Vyacheslav I. Krasnov, Tatyana V. Rybalova, Maksim P. Pitukhin, Irina V. Sorokina, Tatyana G. Tolstikova, Andrey G. Pokrovsky, Anastasia I. Poltanovich, Elvira E. Shults   +11 more
doaj   +1 more source

Multidimensional Engineering Enabling Rate‐Matched C−N Coupling for Efficient Organonitrogen Electrosynthesis

EcoEnergy, EarlyView.
This review introduces rate matching as a unifying design principle for efficient electrochemical C−N coupling and highlights multidimensional engineering of catalysts, interfaces, and reactors to synchronize the generation of carbon‐ and nitrogen‐containing intermediates, balance their surface coverages, maximize C−N bond formation, and enable ...
Kaixing Cai, Chunyang Pu, Jun Yang, Guangqin Li, Jiahui Xian   +4 more
wiley   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

5-(Benzoyloxymethyl)isoxazole-3-carboxylic Acid Ethyl Ester

Molbank
We describe here the palladium hydrogenation of ethyl 5-(benzoyloxymethyl)isoxazole-3-carboxylate. The presence of two reducible sites in the molecule, namely the benzylic-like position and the isoxazole N–O bond, creates a possible competition.
Cosimo Antonini, Franca M. Cordero, Fabrizio Machetti   +2 more
doaj   +1 more source

Electrochemical Synthesis of Isoxazoles and Isoxazolines via Anodic Oxidation of Oximes

ChemElectroChem, 2023
Isoxazol(in)es are widely featured structural motifs in natural products, agrochemicals, and pharmaceuticals. The first intermolecular approach for a direct electrochemical synthesis from readily available aldoximes is reported.
Silja Hofmann, Johannes Winter, Tobias Prenzel, Dr. María deJesús Gálvez‐Vázquez, Prof. Dr. Siegfried R. Waldvogel   +4 more
doaj   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Machine learning‐driven advances in carbon‐based quantum dots: Opportunities accompanied by challenges

Responsive Materials, EarlyView.
Machine learning provides a unifying framework to connect structure, fluorescence properties, and applications of carbon‐based quantum dots. This review highlights how data‐driven strategies enable fluorescence regulation, reveal underlying mechanisms, and accelerate the rational design of functional carbon dots.
Liangfeng Chen, Siwei Yang, Xiangqian Cui, Ziheng Liu, Hang Wang, Yongqiang Li, Peng He, Miao Wang, Guqiao Ding   +8 more
wiley   +1 more source

Therapeutic potential of a Bax inhibitor‐1/TMBIM6 antagonist (BIA) and its analogues in Aspergillus fumigatus‐induced asthma via dual targeting of AKT and epithelial‐derived inflammatory cytokines

British Journal of Pharmacology, EarlyView.
Background and Purpose Aspergillus fumigatus (A. fumigatus) exposure causes of severe allergic asthma, characterized by airway inflammation and epithelial dysfunction. TMBIM6 (Bax inhibitor‐1) has been implicated in airway epithelial stress responses and AKT signalling.
Young‐Jin Yu, Ahsan Ullah, Jisun Kim, Mehedi Hasan Bappi, Yerim Heo, Jin Hee Ahn, Hyun‐Kyoung Kim, Han‐Jung Chae   +7 more
wiley   +1 more source

Síntesis y evaluación “in vitro” de la actividad antifúngica de oximas, éteres de oxima e isoxazoles

Universitas Scientiarum, 2011
Synthesis and in vitro assessment of antifungal activity of oximes, oxime ethers and isoxazoles. Objective. To synthesize and carryout a preliminary evaluation of the in vitro antifungal activity of oximes, oxime ethers and isoxazoles.
John Diaz-Velandia, Natalia Durán-Díaz, Jorge Robles-Camargo, Alix Elena Loaiza   +3 more
doaj  

Tolerância de híbridos de milho ao herbicida isoxaflutole Tolerance of corn hybrids to isoxaflutole

Planta Daninha, 2008
Objetivou-se com este trabalho avaliar a tolerância de híbridos de milho ao isoxaflutole e relacionar estudos de seletividade desse herbicida conduzidos em casa de vegetação com estudos desenvolvidos em campo.
S.D. Cavalieri, R.S. Oliveira Jr, J. Constantin, D.F. Biffe, E.C. Dvoranen, E. Blainski   +5 more
doaj   +1 more source