Results 51 to 60 of about 3,701 (179)

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, Volume 13, Issue 38, 9 July 2026.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Acridine–Isoxazole and Acridine–Azirine Hybrids: Synthesis, Photochemical Transformations in the UV/Visible Radiation Boundary Region, and Anticancer Activity

Molecules
Easy-to-handle N-hydroxyacridinecarbimidoyl chloride hydrochlorides were synthesized as convenient nitrile oxide precursors in the preparation of 3-(acridin-9/2-yl)isoxazole derivatives via 1,3-dipolar cycloaddition with terminal alkynes, 1,1 ...
Ekaterina E. Galenko, Mikhail S. Novikov, Alexander S. Bunev, Alexander F. Khlebnikov   +3 more
doaj   +1 more source

Relapses, Comorbidities, and Predictors of Outcome in Anti‐GABAA Receptor Encephalitis

Annals of Neurology, Volume 100, Issue 1, Page 139-150, July 2026.
Objectives To characterize the magnetic resonance imaging (MRI) lesion dynamics, comorbidities, predictors of relapse, and outcomes in anti‐γ‐aminobutyric acid type A receptor (GABAAR) encephalitis, and assess the utility of LIM‐domain‐only‐protein 5 (LMO5) antibodies as tumor markers.
Claudia Papi, Chiara Milano, Laura Marmolejo, Ana Beatriz Serafim, Esther Aguilar, Mar Guasp, Elianet Fonseca, Mateus Mistieri Simabukuro, Raffaele Iorio, Yuki Fukami, Maria Lucia Schmitz Ferreira Santos, Takashi Miwa, Takashi Araga, Yuto Uchida, Masanori Kurihara, Satoshi Okada, Luz Victoria Garcia, Kenichi Kaida, Natalia Spinola Costa da Cunha, Alberto Vogrig, Florian Lamblin, Juna M. de Vries, Livia Almeida Dutra, Romana Höftberger, Maarten J. Titulaer, Jesús Planagumà, Lidia Sabater, Eugenia Martinez‐Hernandez, Thais Armangué, Francesc Graus, Takahiro Iizuka, Josep Dalmau, Marianna Spatola, Anti‐GABAAR encephalitis study group   +33 more
wiley   +1 more source

Regioselective synthesis of heterocyclic N-sulfonyl amidines from heteroaromatic thioamides and sulfonyl azides

Beilstein Journal of Organic Chemistry, 2020
N-Sulfonyl amidines bearing 1,2,3-triazole, isoxazole, thiazole and pyridine substituents were successfully prepared for the first time by reactions of primary, secondary and tertiary heterocyclic thioamides with alkyl- and arylsulfonyl azides.
Vladimir Ilkin, Vera Berseneva, Tetyana Beryozkina, Tatiana Glukhareva, Lidia Dianova, Wim Dehaen, Eugenia Seliverstova, Vasiliy Bakulev   +7 more
doaj   +1 more source

Clinical validation of a patient‐friendly saliva microsampling approach to monitor perampanel levels in people with epilepsy

Epilepsia, Volume 67, Issue 7, Page e102-e108, July 2026.
Abstract Perampanel (PER) is a third‐generation antiseizure medication (ASM) with a well‐established concentration–effect relationship. Saliva represents a non‐invasive alternative to plasma for therapeutic drug monitoring (TDM) of PER, as it reflects the free plasma fraction.
Valentina Franco, Francesca Dattrino, Michela Palmisani, Federica Tacchella, Elena Tartara, Valentina De Giorgis, Carlo Alberto Quaranta, Ludovica Pasca, Paola Rota, Emilio Russo, Andrea Romigi, Cecilie Johannessen Landmark, Guido Fedele, Cristina Tassorelli, Pierluigi Nicotera   +14 more
wiley   +1 more source

Isoxazole Derivatives as Regulators of Immune Functions

Molecules, 2018
In this review, we present reports on the immunoregulatory properties of isoxazole derivatives classified into several categories, such as immunosuppressive, anti-inflammatory, immunoregulatory, and immunostimulatory compounds.
Michał Zimecki, Urszula Bąchor, Marcin Mączyński   +2 more
doaj   +1 more source

Dexmedetomidine Rapidly Relieves Stress‐Induced Hyperalgesia via Presynaptic α2‐Adrenergic Inhibition at Orbitofrontal–Insular Glutamatergic Synapses

MedComm, Volume 7, Issue 7, July 2026.
This study identified a maladaptive OFC–AIC glutamatergic circuit in stress‐induced hyperalgesia induction. This critical circuit provides an α2‐AR‐dependent braking target for dexmedetomidine to alleviate excessive glutamatergic transmission and hyperalgesia. ABSTRACT Dexmedetomidine (Dex), an α2‐adrenergic receptor (α2‐AR) agonist, is widely used for
Hui Rong, Yang‐Xun Zhang, Huijie Zhu, Yinyao Li, Yunfan Hou, Yun‐Yong Xie, Lu‐Yao Li, Bei‐Bei Zhang, Shu‐Tao Xie, Wei Zhang, Qi‐Peng Zhang, Xiao‐Yang Zhang, Jing‐Ning Zhu, Xiaoping Gu, Zhengliang Ma   +14 more
wiley   +1 more source

Fluorescent Probes from Aromatic Polycyclic Nitrile Oxides: Isoxazoles versus Dihydro‐1λ3,3,2λ4‐Oxazaborinines

ChemistryOpen, 2019
Anthracenenitrile oxide undergoes 1,3‐dipolar cycloaddition reaction with propargyl bromide affording the expected isoxazole as single regioisomer, suitably synthetically elaborated and functionalized with a protected triple bond.
Dr. Mattia Moiola, Dr. Antonio Bova, Dr. Stefano Crespi, Dr. Misal G. Memeo, Prof. Mariella Mella, Prof. Herman S. Overkleeft, Dr. Bogdan I. Florea, Prof. Paolo Quadrelli   +7 more
doaj   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Synthesis and Antimicrobial Evaluation of Some Heterocyclic Chalcone Derivatives

Molecules, 2011
Some new heterocyclic compounds containing isoxazole, pyrazole and oxadiazole ring systems were prepared from various chalcones. The synthesized compounds have been characterized by elemental analysis and spectral methods.
Essam Mohamed Sharshira, Nagwa Mohamed Mahrous Hamada   +1 more
doaj   +1 more source