Results 71 to 80 of about 5,265 (218)
Dual‐Site Catalysis in Electrocatalytic C–N Coupling: Challenges and Design Principles
ChemElectroChem, Volume 13, Issue 11, 3 June 2026.This review examines dual‐site catalysis in electrocatalytic C─N coupling through four recurring challenges: energetic barriers, kinetic mismatch, selectivity loss, and systemic constraints. It highlights how rationally designed dual‐site catalysts cooperatively lower reaction barriers, synchronize intermediate generation, suppress competing pathways ...
Tao You +3 more
wiley +1 more source
Synthesis of Isoxazoles via Electrophilic Cyclization
, 2016 A variety of 3,5-disubstituted 4-halo(seleno)isoxazoles are readily prepared in good to excellent yields under mild reaction conditions by the reaction of 2-alkyn-1-one O-methyl oximes with ICl, I2, Br2, or ...
Richard C. Larock (1353099) +1 more
core +1 more source
ChemistryEurope, Volume 4, Issue 6, June 2026.Polycyclic intermediates enable stereocontrolled synthesis of densely functionalized cis‐1,3‐diamine and amino alcohol carbocycles and heterocycles via structural‐to‐functional complexity transformations from low‐complexity starting material. Cis‐1,3‐functionalized carbocycles and saturated heterocycles are ubiquitous motifs in natural products ...
Jiayi Zhu +2 more
wiley +1 more source
Synthesis and Antimicrobial Evaluation of Some Heterocyclic Chalcone Derivatives
Molecules, 2011 Some new heterocyclic compounds containing isoxazole, pyrazole and oxadiazole ring systems were prepared from various chalcones. The synthesized compounds have been characterized by elemental analysis and spectral methods.
Essam Mohamed Sharshira +1 more
doaj +1 more source
An interesting fragmentation during the thermoiysis of azido isoxazoles
, 1979 Thermolysis of azido isoxazoles has been found to give cinnamoyl cyanides formed by facile fragmentation of the isoxazole ...
Balasubramanian, K. K. +3 more
core +1 more source
Acta Physiologica, Volume 242, Issue 6, June 2026.ABSTRACT Aim The alkali cation/proton exchanger NHE6/SLC9A6 regulates luminal pH homeostasis and trafficking of recycling endosomes in most tissues, especially neurons. Loss‐of‐function mutations in NHE6 cause Christianson Syndrome, an X‐linked neurodevelopmental and neurodegenerative disorder; however, the underlying molecular and cellular mechanisms ...
Rebecca Flessner +6 more
wiley +1 more source
Synthesis of 3,5-Disubstituted Isoxazoles via Cope-Type Hydroamination of 1,3-Dialkynes
, 2016 An efficient method for the synthesis of 3,5-disubstituted isoxazoles is described. The reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in DMSO under mild reaction conditions to produce 3,5-disubstituted isoxazoles in satisfactory to ...
Xiaoqiang Yu (128293) +3 more
core +1 more source
Synergistische Entwicklungsstrategien von Inhibitoren gegen humane UDP‐Galactose‐4‐Epimerase
Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.Die Epimerase GalE ist essenziell für die Biosynthese von krebsrelevanten O‐GalNAc Glykanen. Wir verwenden orthogonales, strukturbasiertes Screening niedermolekularer Fragmente an, um kovalente und nichtkovalente Inhibitoren gegen GalE mit nicht mehr als 22 optimierten Verbindungen zu erhalten.
William M. Browne +22 more
wiley +1 more source
Synthesis of substituted isoxazoles
, 2013 Darbā veikta noteiktu izoksazolu atvasinājumu sintēze, kas kalpotu kā nepeptīdiskie inhibitori malārijas ārstēšanai. Pierādīta iegūto savienojumu struktūra un noteikta to aktivitāte uz plazmepsīnu II.
Kolesnikova, Ksenia
core
Step-by-Step Multifunctionalization of Isoxazoles Based On SEAr Reactions and C–H Direct Arylations
, 2017 Functionalized isoxazoles are important as pharmaceuticals and agrochemicals. Generally, electrophilic aromatic substitution or generation of carbanions/electrophilic trapping approach is used to introduce functional groups into unsubstituted ...
Taiki Morita +2 more
core +1 more source