Results 61 to 70 of about 5,810 (212)

Real‐Time Neurochemical Sensing in Zebrafish: Electrochemical and Fluorescent Approaches

open access: yesAnalysis &Sensing, Volume 6, Issue 6, November 2026.
The use of zebrafish has emerged as a powerful approach for real‐time neurochemical measurements. This review highlights recent advances in electrochemical and fluorescent sensing strategies that enable dynamic measurements in live preparations of this complex vertebrate. These complementary approaches provide new insights into neurochemical signaling,
Piyanka Hettiarachchi   +2 more
wiley   +1 more source

(1RS,3SR)-1-(4-Methylbenzyl)-7-phenyl-5-oxa-6-azaspiro[2.4]hept-6-en-4-one

open access: yesMolbank
The previously unknown cyclopropane spiro-fused with isoxazol-5-one ((1RS,3SR)-1-(4-methylbenzyl)-7-phenyl-5-oxa-6-azaspiro[2.4]hept-6-en-4-one) was synthesized from benzylideneisoxazol-5-one in 34% yield via double methylene transfer from diazomethane ...
Gleb D. Titov, Nikolai V. Rostovskii
doaj   +1 more source

Fluorescent Probes from Aromatic Polycyclic Nitrile Oxides: Isoxazoles versus Dihydro‐1λ3,3,2λ4‐Oxazaborinines

open access: yesChemistryOpen, 2019
Anthracenenitrile oxide undergoes 1,3‐dipolar cycloaddition reaction with propargyl bromide affording the expected isoxazole as single regioisomer, suitably synthetically elaborated and functionalized with a protected triple bond.
Dr. Mattia Moiola   +7 more
doaj   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

open access: yesMedicinal Research Reviews, Volume 46, Issue 6, Page 1735-1752, November 2026.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino   +3 more
wiley   +1 more source

Molecular Recognition by a Tris(phenylisoxazolyl)Benzene Derivative Under Flow‐Through Conditions

open access: yesAdvanced Sensor Research
The application of host molecules as separation media has attracted considerable attention owing to their intrinsic molecular recognition capabilities. Herein, we report the host–guest complexation behavior of a tris(phenylisoxazolyl)benzene derivative ...
Mao Kawasaki   +4 more
doaj   +1 more source

Deciphering Solvation Chemistry for Low‐Temperature Lithium‐Ion Battery Electrolytes: Mechanisms, Strategies, and Beyond

open access: yesRare Metals, Volume 45, Issue 11, November 2026.
ABSTRACT Low‐temperature performance degradation limits lithium‐ion batteries (LIBs) in extreme climates and specialized applications. Electrolytes govern Li+ transport and interfacial reactions, whereas their solvation chemistry controls ionic conductivity, desolvation kinetics, and interphase stability.
Yuqing Chen   +7 more
wiley   +1 more source

Synthesis and Antimicrobial Evaluation of Some Heterocyclic Chalcone Derivatives

open access: yesMolecules, 2011
Some new heterocyclic compounds containing isoxazole, pyrazole and oxadiazole ring systems were prepared from various chalcones. The synthesized compounds have been characterized by elemental analysis and spectral methods.
Essam Mohamed Sharshira   +1 more
doaj   +1 more source

Tuning the Triazolotriazine Scaffold Toward Selective A3 Adenosine Receptor Antagonists: From Molecular Recognition to Neuroprotection

open access: yesChemMedChem, Volume 21, Issue 20, 28 October 2026.
Structure‐based optimization of the triazolo‐triazine scaffold afforded highly potent and selective adenosine A3 receptor antagonists. Replacement of the classical 2‐furyl group with phenyl‐based substituents markedly improved A3 receptor affinity and selectivity.
Veronika Kost   +12 more
wiley   +1 more source

Acridine–Isoxazole and Acridine–Azirine Hybrids: Synthesis, Photochemical Transformations in the UV/Visible Radiation Boundary Region, and Anticancer Activity

open access: yesMolecules
Easy-to-handle N-hydroxyacridinecarbimidoyl chloride hydrochlorides were synthesized as convenient nitrile oxide precursors in the preparation of 3-(acridin-9/2-yl)isoxazole derivatives via 1,3-dipolar cycloaddition with terminal alkynes, 1,1 ...
Ekaterina E. Galenko   +3 more
doaj   +1 more source

Divergent Reactivity in the Reaction of β‑Oxodithioesters and Hydroxylamine: Access to β‑Ketonitriles and Isoxazoles

open access: yes, 2015
Starting from β-oxodithioesters and hydroxylamine, two completely different transformations afford either β-ketonitriles or isoxazoles with high chemoselectivity depending on the reaction conditions.
Jiaheng Li (1490077)   +5 more
core   +1 more source

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