Results 61 to 70 of about 7,470 (229)

Rational Design, Synthesis and Biological Evaluation of Pyrimidine-4,6-diamine derivatives as Type-II inhibitors of FLT3 Selective Against c-KIT. [PDF]

, 2018
FMS-like Tyrosine Kinase 3 (FLT3) is a clinically validated target for acute myeloid leukemia (AML). Inhibitors targeting FLT3 have been evaluated in clinical studies and have exhibited potential to treat FLT3-driven AML.
Bharate, Jaideep B, Ding, Lucky, Frett, Brendan, Lakkaniga, Naga Rajiv, Li, Hong-Yu, McConnell, Nicholas, Naresh, Gunaganti, Shah, Neil P, Zhang, Lingtian   +8 more
core   +2 more sources

Push–Pull Ynamines and Push–Pull Ynamides: Synthesis, Structure, Reactivity, and Application

European Journal of Organic Chemistry, EarlyView.
Push–pull ynamines and push–pull ynamides, which carry an EWG and an amino or amido group as EDG, are highly interesting classes of EDG‐EWG alkynes that have been intensively studied due to their exceptional reactivity. In this review, the synthesis, structure, reactivity, and application of push–pull ynamines, push–pull ynecarbamates, push–pull ...
Hans‐Joachim Gais
wiley   +1 more source

One‐Pot Amidation/C─H Halogenation by an Efficient Electrochemical Cascade

Angewandte Chemie, Volume 138, Issue 19, 4 May 2026.
A sustainable electrochemical cascade enables the one‐pot synthesis of regioselectively halogenated N‐aryl amides from readily available amines and acyl halides under mild conditions. The method merges amidation and C─H halogenation in a single operational step, delivering broad substrate scope, high selectivity, and scalability, and provides an ...
Sudipta Ponra, Ruzal Sitdikov, Hasil Aman, Alyssio Calis, Gergely Laczkó, Virgile Rouffeteau, Maxime R. Vitale, Imre Pápai, Oscar Verho   +8 more
wiley   +2 more sources

(1RS,3SR)-1-(4-Methylbenzyl)-7-phenyl-5-oxa-6-azaspiro[2.4]hept-6-en-4-one

Molbank
The previously unknown cyclopropane spiro-fused with isoxazol-5-one ((1RS,3SR)-1-(4-methylbenzyl)-7-phenyl-5-oxa-6-azaspiro[2.4]hept-6-en-4-one) was synthesized from benzylideneisoxazol-5-one in 34% yield via double methylene transfer from diazomethane ...
Gleb D. Titov, Nikolai V. Rostovskii
doaj   +1 more source

Cyclodextrin-based catalysts and molecular reactors [PDF]

, 2015
We suggest two nonparametric approaches, based on kernel methods and orthogonal series to estimating regression functions in the presence of instrumental variables. For the first time in this class of problems, we derive optimal convergence rates, and
Easton, Christopher J.
core   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, EarlyView.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2 [PDF]

, 2015
In the present study, we used solution combustion synthesis-bismuth oxide (Bi2O3) as catalyst for the simple and efficient synthesis of 1,2-oxazine based derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazoles, 1-arylpiperazine and carbazoles.
Baburajeev, C.P., Basappa, ., Bender, A., Chandra, ., Fuchs, J.E., Jagadish, S., Madegowda, M., Mason, D.J., Mohan, C.D., Rangappa, K.S., Rangappa, S., Sharath Kumar, K.S., Srinivas, V., Sukhorukov, A.Y.   +13 more
core   +1 more source

Base‐Mediated Synthesis of Sulfur‐Substituted Imides using N‐(acyloxy)‐Tetrachlorophthalimides/Anhydrides and Alkyl Isothiouronium Salts

European Journal of Organic Chemistry, EarlyView.
An efficient, scalable, and versatile base‐triggered synthesis of sulfur‐substituted imides with the utility of alkyl isothiouronium salts and masked carboxylic acids under mild reaction conditions. Imides have a vast presence in pharmaceuticals and natural products, and their synthesis generally relies on the utility of the disagreeable strong ...
Malibongwe P. Shandu, Andile R. Ngwenya, Madelien Wooding, Jairus L. Lamola, Paseka T. Moshapo   +4 more
wiley   +1 more source

Molecular Recognition by a Tris(phenylisoxazolyl)Benzene Derivative Under Flow‐Through Conditions

Advanced Sensor Research
The application of host molecules as separation media has attracted considerable attention owing to their intrinsic molecular recognition capabilities. Herein, we report the host–guest complexation behavior of a tris(phenylisoxazolyl)benzene derivative ...
Mao Kawasaki, Yudai Ono, Tomoko Amimoto, Takehiro Hirao, Takeharu Haino   +4 more
doaj   +1 more source

Synthesis and Antimicrobial Activity of N′-Heteroarylidene-1-adamantylcarbohydrazides and (±)-2-(1-Adamantyl)-4-acetyl-5-[5-(4-substituted phenyl-3-isoxazolyl)]-1,3,4-oxadiazolines

Molecules, 2012
The reaction of adamantane-1-carbohydrazide (1) with heterocyclic aldehydes, namely 5-(4-chlorophenyl)isoxazole-3-carboxaldehyde (2a), 5-(4-methylphenyl)isoxazole-3-carboxaldehyde (2b), 5-(4-methoxyphenyl)isoxazole-3-carboxaldehyde (2c), 1H-imidazole-2 ...
Abdul-Malek S. Al-Tamimi, Ali A. El-Emam, Mohamed A. Al-Omar, Khalid A. Alrashood   +3 more
doaj   +1 more source