European Journal of Neurology, Volume 33, Issue 9, September 2026.ABSTRACT Background Neurological and psychiatric disorders pose a persistent global health burden, with conventional therapies often providing inadequate relief. Transcranial ultrasound stimulation (TUS) has attracted considerable attention as a non‐invasive neuromodulation technique offering high spatial resolution and the distinctive capacity to ...
Yunjie Sui +3 more
wiley +1 more source
Synthesis of Isoxazoles via Electrophilic Cyclization
, 2016 A variety of 3,5-disubstituted 4-halo(seleno)isoxazoles are readily prepared in good to excellent yields under mild reaction conditions by the reaction of 2-alkyn-1-one O-methyl oximes with ICl, I2, Br2, or ...
Richard C. Larock (1353099) +1 more
core +1 more source
Structure‐Guided Optimization of a Molecular Glue Targeting the KBTBD4‐HDAC1/2 Complex
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Structure‐based optimization of the molecular glue degrader UM171 resulted in a near 20‐fold improvement of ternary complex stability but also revealed the challenges of glue discovery. Optimization of UM171, a molecular glue initiating the degradation of neosubstrate HDAC1/2–CoREST–LSD1 through a multiprotein complex formed with KBTBD4, was carried ...
Timea Balo +8 more
wiley +1 more source
Synthesis of substituted isoxazoles
, 2013 Darbā veikta noteiktu izoksazolu atvasinājumu sintēze, kas kalpotu kā nepeptīdiskie inhibitori malārijas ārstēšanai. Pierādīta iegūto savienojumu struktūra un noteikta to aktivitāte uz plazmepsīnu II.
Kolesnikova, Ksenia
core
An interesting fragmentation during the thermoiysis of azido isoxazoles
, 1979 Thermolysis of azido isoxazoles has been found to give cinnamoyl cyanides formed by facile fragmentation of the isoxazole ...
Balasubramanian, K. K. +3 more
core +1 more source
Calcium-mediated one-pot preparation of isoxazoles with deuterium incorporation
, 2018 In this work, a novel synthetic methodology for the one-pot preparation of isoxazoles directly from the reaction of calcium carbide with aldoximes is reported.
Konstantin S. Rodygin +2 more
core +1 more source
Synthesis of 3,5-Disubstituted Isoxazoles via Cope-Type Hydroamination of 1,3-Dialkynes
, 2016 An efficient method for the synthesis of 3,5-disubstituted isoxazoles is described. The reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in DMSO under mild reaction conditions to produce 3,5-disubstituted isoxazoles in satisfactory to ...
Xiaoqiang Yu (128293) +3 more
core +1 more source
Síntesis de C-glicosil isoxazoles con potencial actividad biológica mediante adición 5-endo-trig de radicales iminoxilo catalizada por tempo [PDF]
, 2016 La síntesis de diversos C-glicosilmetil isoxazoles ha sido llevada a cabo mediante adición intramolecular 5-endo-trig de radicales iminoxilo generados a partir de cetoximas alfa, beta - insaturadas.
Llantén Martínez, Helberth Jesús
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Copper(0) Nanoparticles in Click Chemistry: Synthesis of 3,5-Disubstituted Isoxazoles
, 2015 An efficient procedure for the synthesis of 3,5-disubstituted isoxazoles via 3+2 cycloaddition reaction of in situ generated nitrile oxides with acetylenes employing readily preparable copper(0) nanoparticles is described.
Vishwanatha, T.M., Sureshbabu, V.V.
core +1 more source
Step-by-Step Multifunctionalization of Isoxazoles Based On SEAr Reactions and C–H Direct Arylations
, 2017 Functionalized isoxazoles are important as pharmaceuticals and agrochemicals. Generally, electrophilic aromatic substitution or generation of carbanions/electrophilic trapping approach is used to introduce functional groups into unsubstituted ...
Taiki Morita +2 more
core +1 more source