Results 81 to 90 of about 7,470 (229)

Fluorescent Probes from Aromatic Polycyclic Nitrile Oxides: Isoxazoles versus Dihydro‐1λ3,3,2λ4‐Oxazaborinines

ChemistryOpen, 2019
Anthracenenitrile oxide undergoes 1,3‐dipolar cycloaddition reaction with propargyl bromide affording the expected isoxazole as single regioisomer, suitably synthetically elaborated and functionalized with a protected triple bond.
Dr. Mattia Moiola, Dr. Antonio Bova, Dr. Stefano Crespi, Dr. Misal G. Memeo, Prof. Mariella Mella, Prof. Herman S. Overkleeft, Dr. Bogdan I. Florea, Prof. Paolo Quadrelli   +7 more
doaj   +1 more source

Metal‐Free Electrophilic Borylative Cyclizations of Alkynes

The Chemical Record, EarlyView.
Metal‐free borylative cyclizations based on electrophilic alkyne activation by boron Lewis acids provide efficient access to borylated hetero‐ and carbocycles. Early studies using B(C6F5)3 displayed limited scope and application, whereas recent ClBcat‐ and BCl3‐based methods enable mild CB and CC/CX bond formation for the synthesis of cycles ...
Jaime Mateos‐Gil, Marcos Humanes, Manuel A. Fernández‐Rodríguez, Patricia García‐García   +3 more
wiley   +1 more source

Iterative approach to computational enzyme design [PDF]

, 2012
A general approach for the computational design of enzymes to catalyze arbitrary reactions is a goal at the forefront of the field of protein design. Recently, computationally designed enzymes have been produced for three chemical reactions through the ...
Blomberg, Rebecca, Chica, Roberto A., Hilvert, Donald, Houk, Kendall N., Kiss, Gert, Lee, Toni M., Mayo, Stephen L., Privett, Heidi K., Thomas, Leonard M.   +8 more
core   +2 more sources

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Synthesis and Antimicrobial Evaluation of Some Heterocyclic Chalcone Derivatives

Molecules, 2011
Some new heterocyclic compounds containing isoxazole, pyrazole and oxadiazole ring systems were prepared from various chalcones. The synthesized compounds have been characterized by elemental analysis and spectral methods.
Essam Mohamed Sharshira, Nagwa Mohamed Mahrous Hamada   +1 more
doaj   +1 more source

Sintesis de isoxazol utilizando ultrasonido, para su posterior cambio estructural en microondas y medicion de actividad biologica [PDF]

, 2010
63 p.Los isoxazoles son una clase de heterociclos, que presentan una gran diversidad de actividades biológicas, dependiendo del sustituyente utilizado, este heterociclo posee una actividad biológica determinada entre las que se puede destacar ...
Astudillo Saavedra, Luis (Prof. Guía), Benavides Bobadilla, Andrea   +1 more
core  

Recent developments in chemical reactivity of N,N-dimethylenamino ketones as synthons for various heterocycles [PDF]

, 2017
The current review presents recent progress in the utility of N,N-dimethyl enaminones as building blocks for a diverse range of acyclic, carbocyclic, five- and six-membered heterocyclic a broad range of heterocyclic and fused heterocyclic derivatives ...
Abbas, Abdallah, Abdallah, Abdallah, Abdel-Khalik, Abdel-Khalik, Abdel-Khalik, Abdel-Megid, Abdel-Motaleb, Abdel-Motaleb, Abdelhamid, Abdelhamid, AbdelKhalik, Abu-Shanab, Abu-Shanab, Adams, Agamy, Agamy, Al-Awadi, Al-Awadi, Al-Awadi, Al-Enezi, Al-Etaibi, Al-Mousawi, Al-Mousawi, Al-Mousawi, Al-Mousawi, Al-Mousawi, Al-Mousawi, Al-Mousawi, Al-Omran, Al-Omran, Al-Omran, Al-Omran, Al-Omran, Al-Omran, Al-Omran, Al-Omran, Al-Saleh, Al-Saleh, Al-Saleh, Al-Saleh, Al-Saleh, Al-Saleh, Al-Saleh, Al-Saleh, Al-Shiekh, Al-Shiekh, Al-Shiekh, Al-Zaydi, Al-Zaydi, Al-Zaydi, Al-Zaydi, Al-Zaydi, Al-Zaydi, Al-Zaydi, Alinezhad, Alinezhad, Almazroa, Anwer, Behbehani, Cao, Dawood, Domínguez, El-Desoky, El-Dusouqui, El-Taweel, Eldebss, Elghamry, Farghaly, Figueiredo, Gaber, Gaber, Gaber, Gaber, Gaber, Gaber, Gad-Elkareem, Gad-Elkareem, Ghozlan, Ghozlan, Ghozlan, Gomha, Gomha, Gomha, Gomha, Gomha, Greenhill, Hassanien, Hassanien, Hassanien, Hernández, Ho, Ho, Ho, Hughes, Ibrahim, Igarashi, Ingham, Jiang, Kandeel, Kantevari, Kascheres, Katritzky, Katritzky, Kenawi, Kepe, Kepe, Kim, Kirschbaum, Liu, Lue, Macba, Macba, Makhseed, Manley, Martins, Michael, Mokhtar, Mousawi, Moustafa, Mukhanova, Murphy, Negri, Nishimura, Nishiyama, Pichon, Pigge, Pleier, Raghunadh, Rasmussen, Reidlinger, Sabnis, Saleh, Salomone, Schenone, Shaaban, Shankaraiah, Sherif, Toche, Tois, Trautwein, Verma, Wan, Wan, Wan, Wan, Wan, Wang, Witherington, Xiang, Zhao, Zhou, Šimůnek   +153 more
core   +1 more source

The Recycling Endosomal (Na+, K+)/H+ Exchanger NHE6/SLC9A6 Facilitates Signal Transduction by Shuttling Cyclin‐Dependent Kinase 5 to the Plasma Membrane

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim The alkali cation/proton exchanger NHE6/SLC9A6 regulates luminal pH homeostasis and trafficking of recycling endosomes in most tissues, especially neurons. Loss‐of‐function mutations in NHE6 cause Christianson Syndrome, an X‐linked neurodevelopmental and neurodegenerative disorder; however, the underlying molecular and cellular mechanisms ...
Rebecca Flessner, Alina Ilie, Léo Han, Annie Boucher, Rebecca Anne McKinney, Reza Sharif‐Naeini, John Orlowski   +6 more
wiley   +1 more source

Sintesis de derivados isoxazolil quinolinicos y su actividad biologica [PDF]

, 2009
48 p.Sabidas, son las variadas propiedades que presentan tanto los isoxazoles, como las quinolinas en varios ámbitos hoy en día; Presentan grandes actividades a nivel de antiagregante plaquetario, antifúngicos, inhibidores de enzimas, etc.
Acuna Martinez, Sara, Astudillo Saavedra, Luis (Prof. Guía)   +1 more
core  

Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Cerebral Cortical Encephalitis: A Comparative Study With Antibody‐Negative and Non‐MOG Antibody‐Positive Cortical Encephalitis in Chinese Adults

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
MOG antibody‐associated cortical encephalitis (MOG‐CCE) presents a distinct clinical phenotype characterized by seizure‐dominant onset, unilateral cortical lesions, and favorable immunotherapy response, highlighting the diagnostic and prognostic value of antibody profiling in autoimmune cortical encephalitis.
Qing Yin, Binhong Han, Kai Su, Weiqi Dai, Jing Wu, Li Yang, Yuwei Dai, Dan Wang   +7 more
wiley   +1 more source