Results 91 to 100 of about 7,470 (229)

The development of positron emission tomography (PET) tracer for glutamate AMPA receptors and its application to human biology and clinics

open access: yesPsychiatry and Clinical Neurosciences, Volume 80, Issue 5, Page 367-373, May 2026.
Psychiatric and neurological disorders severely compromised patients' quality of life. Despite their urgent needs, the development of diagnostics and therapeutics based on the biological basis has made only little progress. This is due to limited evidence on the biological basis of these disorders in humans. Synapses are fundamental structural units of
Mai Hatano, Hiroki Abe, Takuya Takahashi
wiley   +1 more source

Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives [PDF]

open access: yes, 2019
The pathological aggregation and accumulation of tau, a microtubule-associated protein, is a common feature amongst more than 18 different neurodegenerative diseases that are collectively known as tauopathies.
Bucchieri, Fabio   +6 more
core   +1 more source

Evaluation of confirmatory data following the Article 12 MRL review for isoxaben

open access: yesEFSA Journal, Volume 24, Issue 5, May 2026.
Abstract The applicant Corteva Agriscience International Sàrl submitted a request to the competent national authority in Sweden to evaluate the confirmatory data that were identified for isoxaben in the framework of the maximum residue level (MRL) review under Article 12 of Regulation (EC) No 396/2005 as not available.
European Food Safety Authority (EFSA)   +18 more
wiley   +1 more source

Stereoselective synthesis of α-amino-C-phosphinic acids and derivatives [PDF]

open access: yes, 2016
α-Amino-C-phosphinic acids and derivatives are an important group of compounds of synthetic and medicinal interest and particular attention has been dedicated to their stereoselective synthesis in recent years. Among these, phosphinic pseudopeptides have
Cativiela, Carlos   +3 more
core   +3 more sources

From Mechanisms to Materials: Oximate Reactivity and Emerging Strategies for Organophosphate Detoxification

open access: yesChemPhysChem, Volume 27, Issue 7, 14 April 2026.
The development of effective strategies for the detoxification of organophosphorus (OP) nerve agents has evolved from the early mechanistic studies of François Terrier and collaborators, who first elucidated the exceptional nucleophilicity of α‐effect species such as oximes and hydroxamates, to the modern design of supramolecular and material‐based ...
Pedro Rodríguez‐Dafonte
wiley   +1 more source

Xanthines as a scaffold for molecular diversity [PDF]

open access: yes, 2018
Summary: Xanthines represent a new, versatile scaffold for combinatorial chemistry. A five-step solid-phase synthesis of xanthine derivatives is described which includes alkylations, a nucleophilic displacement reaction at a heterocycle and a ring ...
Eberle, Alex, Heizmann, Gerhard
core  

Synthesis, characterization and X-ray crystal structures of chiral ferrocene-containing β-diketones [PDF]

open access: yes, 2013
CCDC 922490, 922491, and 922492 contain the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif.International audienceThree ...
Ahumada, Guillermo   +5 more
core   +3 more sources

Contrasts among origins of corn hybrids in relation to their susceptibility to nicosulfuron and isoxaflutole herbicides
Contrastes entre procedências de híbridos de milho em relação à suscetibilidade aos herbicidas nicosulfuron e isoxaflutole

open access: yesSemina: Ciências Agrárias, 2010
Herbicide selectivity is the basis for successfull weed chemical control in agricultural production, as it is considered as a measurement of the difeerential response of different plant species to a certain herbicide.
Rosecler Salete Canossa   +6 more
doaj   +1 more source

Continuous flow chemistry: a discovery tool for new chemical reactivity patterns [PDF]

open access: yes, 2014
Continuous flow chemistry as a process intensification tool is well known. However, its ability to enable chemists to perform reactions which are not possible in batch is less well studied or understood. Here we present an example, where a new reactivity
Hartwig, Jan   +4 more
core   +2 more sources

Cycloaddition of Benzyne with Alkoxy-Substituted Pyrroline-N-oxides­: Unexpected Rearrangement to an N-Phenylpyrrole

open access: yesSynOpen, 2018
Reaction of enantiopure 3,4-dialkoxy-pyrroline N-oxides with benzyne affords the expected tetrahydrobenzo[d]pyrrolo[1,2-b]isoxazoles along with an unexpected 2,3-disubstitued-N-phenyl-pyrrole derived from an unprecedented rearrangement of the adduct of ...
Franca M. Cordero   +3 more
doaj   +1 more source

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