Results 91 to 100 of about 7,470 (229)
Psychiatric and neurological disorders severely compromised patients' quality of life. Despite their urgent needs, the development of diagnostics and therapeutics based on the biological basis has made only little progress. This is due to limited evidence on the biological basis of these disorders in humans. Synapses are fundamental structural units of
Mai Hatano, Hiroki Abe, Takuya Takahashi
wiley +1 more source
Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives [PDF]
The pathological aggregation and accumulation of tau, a microtubule-associated protein, is a common feature amongst more than 18 different neurodegenerative diseases that are collectively known as tauopathies.
Bucchieri, Fabio +6 more
core +1 more source
Evaluation of confirmatory data following the Article 12 MRL review for isoxaben
Abstract The applicant Corteva Agriscience International Sàrl submitted a request to the competent national authority in Sweden to evaluate the confirmatory data that were identified for isoxaben in the framework of the maximum residue level (MRL) review under Article 12 of Regulation (EC) No 396/2005 as not available.
European Food Safety Authority (EFSA) +18 more
wiley +1 more source
Stereoselective synthesis of α-amino-C-phosphinic acids and derivatives [PDF]
α-Amino-C-phosphinic acids and derivatives are an important group of compounds of synthetic and medicinal interest and particular attention has been dedicated to their stereoselective synthesis in recent years. Among these, phosphinic pseudopeptides have
Cativiela, Carlos +3 more
core +3 more sources
The development of effective strategies for the detoxification of organophosphorus (OP) nerve agents has evolved from the early mechanistic studies of François Terrier and collaborators, who first elucidated the exceptional nucleophilicity of α‐effect species such as oximes and hydroxamates, to the modern design of supramolecular and material‐based ...
Pedro Rodríguez‐Dafonte
wiley +1 more source
Xanthines as a scaffold for molecular diversity [PDF]
Summary: Xanthines represent a new, versatile scaffold for combinatorial chemistry. A five-step solid-phase synthesis of xanthine derivatives is described which includes alkylations, a nucleophilic displacement reaction at a heterocycle and a ring ...
Eberle, Alex, Heizmann, Gerhard
core
Synthesis, characterization and X-ray crystal structures of chiral ferrocene-containing β-diketones [PDF]
CCDC 922490, 922491, and 922492 contain the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif.International audienceThree ...
Ahumada, Guillermo +5 more
core +3 more sources
Herbicide selectivity is the basis for successfull weed chemical control in agricultural production, as it is considered as a measurement of the difeerential response of different plant species to a certain herbicide.
Rosecler Salete Canossa +6 more
doaj +1 more source
Continuous flow chemistry: a discovery tool for new chemical reactivity patterns [PDF]
Continuous flow chemistry as a process intensification tool is well known. However, its ability to enable chemists to perform reactions which are not possible in batch is less well studied or understood. Here we present an example, where a new reactivity
Hartwig, Jan +4 more
core +2 more sources
Reaction of enantiopure 3,4-dialkoxy-pyrroline N-oxides with benzyne affords the expected tetrahydrobenzo[d]pyrrolo[1,2-b]isoxazoles along with an unexpected 2,3-disubstitued-N-phenyl-pyrrole derived from an unprecedented rearrangement of the adduct of ...
Franca M. Cordero +3 more
doaj +1 more source

