Results 11 to 20 of about 5,810 (212)

Synthesis of Fused Isoxazoles: A Comprehensive Review

Engineering Proceedings
Pharmaceutically important isoxazoles are within the wide range of heterocycles. The isoxazole ring, being five-membered, is also found in many bioactive natural products in addition to synthetic drugs.
Niveditha N. Mallik, Chandramouli Manasa, Vrushabendra Basavanna, Dileep C. Shanthakumar, Srikantamurthy Ningaiah, Nagarakere S. Lingegowda   +5 more
doaj   +2 more sources

Facile Synthesis of 2-Dimethylamino-Δ-1-Azirine Derivatives by Thermal or Photo-Isomerization of Isoxazoles [1]

CHIMIA, 1976
3,5-Bisdimethylamino-isoxazoles II are obtained easily from 1,3-dichloro-trimethinecyanine I and a water solution of hydroxylamine. Besides precedented photo-isomerization of 4-substituted isoxazoles IIb,c to azirines IIIb,c near quantitative thermal ...
G.J. de Voghel, T.L. Eggerichs, Brigitte Clamot, H.G. Viehe   +3 more
doaj   +2 more sources

Copper-Catalyzed [4+2]-Cycloadditions of Isoxazoles with 2‑Alkynylbenzaldehydes To Access Distinct α‑Carbonylnaphthalene Derivatives: C(3,4)- versus C(4,5)-Regioselectivity at Isoxazoles

, 2019
Cu­(II)-catalyzed [4+2]-cycloadditions occur between Cu–benzopyryliums and substituted isoxazoles with the regioselectivity on the C­(3,4)-carbons of isoxazoles.
Sovan Sundar Giri (6988292), Sovan Sundar Giri, Rai-Shung Liu (1393513), Rai-Shung Liu   +3 more
core   +7 more sources

Síntesis y evaluación “in vitro” de la actividad antifúngica de oximas, éteres de oxima e isoxazoles [PDF]

Universitas Scientiarum, 2011
Synthesis and in vitro assessment of antifungal activity of oximes, oxime ethers and isoxazoles. Objective. To synthesize and carryout a preliminary evaluation of the in vitro antifungal activity of oximes, oxime ethers and isoxazoles.
John Diaz-Velandia, Natalia Durán-Díaz, Jorge Robles-Camargo, Alix Elena Loaiza   +3 more
doaj   +1 more source

Ring-Opening Fluorination of Isoxazoles [PDF]

, 2022
A ring-opening fluorination of isoxazoles has been developed. Upon treatment of isoxazoles with an electrophilic fluorinating agent (Selectfluor), fluorination followed by deprotonation leads to tertiary fluorinated carbonyl compounds.
Masaaki Komatsuda (5482064), Hiroki Kondo, Masaaki Komatsuda, Ayane Suto (12462506), Hugo Ohki (12462503), Junichiro Yamaguchi, Junichiro Yamaguchi (1685833), Ayane Suto, Hugo Ohki, Hiroki Kondo (155338)   +9 more
core   +3 more sources

Mechanochemical Desymmetrization of Unbiased Bis- and Tris-alkynes to Access 3,5-Isoxazoles-Alkyne Adducts and Unsymmetrical Bis-3,5-isoxazoles [PDF]

, 2022
A mechanochemical desymmetrization of symmetrical bis- and tris-alkynes via a controlled 1,3-dipolar cycloaddition reaction with nitrile oxide dipoles has been developed.
Irini , Trakakis, Rafael A., Hernandez R., Jean-Louis , Do, Tomislav , Friščić, Pat , Forgione, Louis A., Cuccia   +5 more
core   +2 more sources

A de-novo Approach Towards Divergent [3+2π/σ] Photocycloadditions of Nitrones via Assembly-Controlled Kinetic Electron Transfer Gating. [PDF]

Angew Chem Int Ed Engl
A metal‐free photocatalytic platform converts nitrones into 4‐isoxazolines and oxa–aza–bicycloheptanes through divergent [3+2π/σ] cycloadditions. Assembly‐controlled kinetic electron transfer gating dictates substrate activation, enabling selective reactivity beyond thermodynamic expectations.
Saha N, Kancherla R, Escorihuela J, Chandran S, Bera MK, Rueping M, König B.   +6 more
europepmc   +3 more sources

Trifluoromethylated Flavonoid-Based Isoxazoles as Antidiabetic and Anti-Obesity Agents: Synthesis, In Vitro α-Amylase Inhibitory Activity, Molecular Docking and Structure–Activity Relationship Analysis

Molecules, 2021
Diabetes mellitus is a major health problem globally. The management of carbohydrate digestion provides an alternative treatment. Flavonoids constitute the largest group of polyphenolic compounds, produced by plants widely consumed as food and/or used ...
Faisal K. Algethami, Ilyes Saidi, Hani Nasser Abdelhamid, Mohamed R. Elamin, Babiker Y. Abdulkhair, Amani Chrouda, Hichem Ben Jannet   +6 more
doaj   +1 more source

[3 + 2] Cycloaddition reactions of nitrile oxides generated in situ from aldoximes with alkenes and alkynes under ball-milling conditions

Green Chemistry Letters and Reviews, 2022
A convenient and efficient [3 + 2] cycloaddition reaction of alkenes and alkynes with the in situ generated nitrile oxides from aldoximes in the presence of NaCl, Oxone and Na2CO3 has been developed to afford a series of isoxazoles and isoxazolines at ...
Run-Kai Fang, Zheng-Chun Yin, Jun-Shen Chen, Guan-Wu Wang   +3 more
doaj   +1 more source

Synthesis and Antiprotozoal Profile of 3,4,5‐Trisubstituted Isoxazoles

ChemistryOpen, 2021
A series of 60 4‐aminomethyl 5‐aryl‐3‐substituted isoxazoles were synthesized by an efficient method and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi, protozoa that cause the neglected tropical diseases leishmaniasis and Chagas
Prof. Fernanda Andreia Rosa, Samara Mendes de Souza Melo, Dr. Karlos Eduardo Pianoski, Julia Poletto, Mariellen Guilherme dosSantos, Dr. Michael Jackson Vieira da Silva, Dr. Danielle Lazarin‐Bidóia, Dr. Hélito Volpato, Prof. Sidnei Moura, Prof. Celso Vataru Nakamura   +9 more
doaj   +1 more source