Results 11 to 20 of about 3,701 (179)

Trifluoromethylated Flavonoid-Based Isoxazoles as Antidiabetic and Anti-Obesity Agents: Synthesis, In Vitro α-Amylase Inhibitory Activity, Molecular Docking and Structure–Activity Relationship Analysis

Molecules, 2021
Diabetes mellitus is a major health problem globally. The management of carbohydrate digestion provides an alternative treatment. Flavonoids constitute the largest group of polyphenolic compounds, produced by plants widely consumed as food and/or used ...
Faisal K. Algethami, Ilyes Saidi, Hani Nasser Abdelhamid, Mohamed R. Elamin, Babiker Y. Abdulkhair, Amani Chrouda, Hichem Ben Jannet   +6 more
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Facile Synthesis of 2-Dimethylamino-Δ-1-Azirine Derivatives by Thermal or Photo-Isomerization of Isoxazoles [1]

CHIMIA, 1976
3,5-Bisdimethylamino-isoxazoles II are obtained easily from 1,3-dichloro-trimethinecyanine I and a water solution of hydroxylamine. Besides precedented photo-isomerization of 4-substituted isoxazoles IIb,c to azirines IIIb,c near quantitative thermal ...
G.J. de Voghel, T.L. Eggerichs, Brigitte Clamot, H.G. Viehe   +3 more
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[3 + 2] Cycloaddition reactions of nitrile oxides generated in situ from aldoximes with alkenes and alkynes under ball-milling conditions

Green Chemistry Letters and Reviews, 2022
A convenient and efficient [3 + 2] cycloaddition reaction of alkenes and alkynes with the in situ generated nitrile oxides from aldoximes in the presence of NaCl, Oxone and Na2CO3 has been developed to afford a series of isoxazoles and isoxazolines at ...
Run-Kai Fang, Zheng-Chun Yin, Jun-Shen Chen, Guan-Wu Wang   +3 more
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Synthesis and Antiprotozoal Profile of 3,4,5‐Trisubstituted Isoxazoles

ChemistryOpen, 2021
A series of 60 4‐aminomethyl 5‐aryl‐3‐substituted isoxazoles were synthesized by an efficient method and evaluated in vitro against Leishmania amazonensis and Trypanosoma cruzi, protozoa that cause the neglected tropical diseases leishmaniasis and Chagas
Prof. Fernanda Andreia Rosa, Samara Mendes de Souza Melo, Dr. Karlos Eduardo Pianoski, Julia Poletto, Mariellen Guilherme dosSantos, Dr. Michael Jackson Vieira da Silva, Dr. Danielle Lazarin‐Bidóia, Dr. Hélito Volpato, Prof. Sidnei Moura, Prof. Celso Vataru Nakamura   +9 more
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5-Chloroisoxazoles: A Versatile Starting Material for the Preparation of Amides, Anhydrides, Esters, and Thioesters of 2H-Azirine-2-carboxylic Acids

Molecules, 2022
Amides, anhydrides, esters, and thioesters of 2H-azirine-2-carboxylic acids were prepared by a rapid procedure at room temperature involving FeCl2-catalyzed isomerization of 5-chloroisoxazoles to 2H-azirine-2-carbonyl chlorides, followed by reaction with
Anastasiya V. Agafonova, Mikhail S. Novikov, Alexander F. Khlebnikov   +2 more
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Isoxazole derivatives as new nitric oxide elicitors in plants

Beilstein Journal of Organic Chemistry, 2017
Several 3,5-disubstituted isoxazoles were obtained in good yields by regiospecific 1,3-dipolar cycloaddition reactions between aromatic nitrile oxides, generated in situ from the corresponding hydroxyimidoyl chlorides, with non-symmetrical activated ...
Anca Oancea, Emilian Georgescu, Florentina Georgescu, Alina Nicolescu, Elena Iulia Oprita, Catalina Tudora, Lucian Vladulescu, Marius-Constantin Vladulescu, Florin Oancea, Calin Deleanu   +9 more
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Electrocyclizations of Conjugated Azapolyenes Produced in Reactions of Azaheterocycles with Metal Carbenes

Organics, 2021
Conjugated azapolyenes (azabuta-1,3-dienes, aza-/diaza-/oxaza-/oxadiazahexa-1,3,5-trienes) are highly reactive in electrocyclization reactions, which makes them convenient precursors for the synthesis of a wide range of four-, five-, and six-membered ...
Nikolai V. Rostovskii, Mikhail S. Novikov, Alexander F. Khlebnikov   +2 more
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Über Triaryl‐isoxazole [PDF]

Berichte der deutschen chemischen Gesellschaft (A and B Series), 1921
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Meisenheimer, Jakob, Weibezahn, Karl
openaire   +2 more sources

Synthesis and Antimicrobial Activity of some Ester Functionalized Isoxazoles incorporating Anthracene Moieties via Nucleophilic Substitution Reaction

Zanco Journal of Medical Sciences, 2023
Background and objective: Five-membered heterocycle compounds having single oxygen and nitrogen atom at adjacent positions are known as isoxazoles. Isoxazole compounds have a broad range of biological activities and therapeutic value.
Sarbast M. Ahmed, Hewa Omer Ahmed, Faiq H. S. Hussain, Hayman Sardar Abdulrahman, Hemn A. Qader   +4 more
doaj  

Synthesis of Fused Isoxazoles: A Comprehensive Review

Engineering Proceedings
Pharmaceutically important isoxazoles are within the wide range of heterocycles. The isoxazole ring, being five-membered, is also found in many bioactive natural products in addition to synthetic drugs.
Niveditha N. Mallik, Chandramouli Manasa, Vrushabendra Basavanna, Dileep C. Shanthakumar, Srikantamurthy Ningaiah, Nagarakere S. Lingegowda   +5 more
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