Results 31 to 40 of about 5,925 (227)

Cycloadditions of cyclohexynes and cyclopentyne. [PDF]

, 2014
We report the strategic use of cyclohexyne and the more elusive intermediate, cyclopentyne, as a tool for the synthesis of new heterocyclic compounds. Experimental and computational studies of a 3-substituted cyclohexyne are also described.
Garg, Neil K, Houk, KN, Jiménez-Osés, Gonzalo, McMahon, Travis C, Medina, Jose M   +4 more
core   +2 more sources

Kinetic Study on the Base-Catalyzed Imine-Enamine Tautomerism of a Chiral Biologically Active Isoxazoline Derivative by HPLC on Amylose Tris(3,5-dimethylphenylcarbamate) Chiral Stationary Phase

Molecules, 2023
Isoxazoline is a nitrogen- and oxygen-containing five-membered heterocyclic scaffold with diverse biological profiles such as antimicrobial, fungicidal, anticancer, antiviral, analgesic and anti-inflammatory activity.
Daniele Sadutto, Paolo Guglielmi, Simone Carradori, Daniela Secci, Roberto Cirilli   +4 more
doaj   +1 more source

The Chemoselective Reduction of Isoxazoline γ-Lactams Through Iminium Aza-Diels-Alder Reactions: A Short-Cut Synthesis of Aminols as Valuable Intermediates towards Nucleoside Derivatives

The Scientific World Journal, 2012
Isoxazoline γ-lactams are prepared starting from the regioisomeric cycloadducts of benzonitrile oxide to the N-alkyl 2-azanorbornenes taking advantage of the efficient catalytic oxidation by RuO4.
Misal Giuseppe Memeo, Mariella Mella, Paolo Quadrelli   +2 more
doaj   +1 more source

An improved model of the Trypanosoma brucei CTP synthetase glutaminase domain-acivicin complex [PDF]

, 2017
The natural product acivicin inhibits the glutaminase activity of CTP synthetase and is a potent lead compound for drug discovery in the area of neglected tropical diseases, specifically trypanosomaisis.
Chen, Conti, Eadsforth, Emsley, Fijolek, Fyfe, Fyffe, Hofer, Hunter, Ida, Kursula, Murshudov, Pinto, Rimsa, Smart, Tamborini, Touw, Wada, Williams   +18 more
core   +2 more sources

A study on selective transformation of norbornadiene into fluorinated cyclopentane-fused isoxazolines

Beilstein Journal of Organic Chemistry, 2021
This work presents an examination of the selective functionalization of norbornadiene through nitrile oxide 1,3-dipolar cycloaddition/ring-opening metathesis (ROM)/cross-metathesis (CM) protocols. Functionalization of commercially available norbornadiene
Zsanett Benke, Attila M. Remete, Loránd Kiss   +2 more
doaj   +1 more source

Discovery of a Novel Class of Acylthiourea-Containing Isoxazoline Insecticides against Plutella xylostella

Molecules, 2023
Isoxazoline structures are widely found in natural products and are rich in biological activities. This study discloses the development of a series of novel isoxazoline derivatives by introducing acylthiourea fragments to access insecticidal activity ...
Fangyi Li, Biaobiao Jiang, Yuqin Luo, Siqi He, Di Feng, Deyu Hu, Runjiang Song   +6 more
doaj   +1 more source

Asymmetric 1,3-dipolar cycloadditions of acrylamides [PDF]

, 2009
This critical review, which is relevant to researchers in synthetic organic chemistry, focuses on asymmetric 1,3-dipolar cycloadditions with acrylamides.
Kissane, Marie, Maguire, Anita R.
core   +1 more source

Synthesis and Pharmacological Significance of Isoxazoline Derivatives: A Mini review

Academic Science Journal
Five-membered heterocycles, like isoxazolines, are an important class of compounds of bioorganic and pharmacological importance. They have been treated as useful intermediates for the transformation of a large number of bioactive molecules.
mohammed alwan
doaj   +1 more source

Combined experimental and theoretical studies of regio- and stereoselectivity in reactions of β-isoxazolyl- and β-imidazolyl enamines with nitrile oxides

Beilstein Journal of Organic Chemistry, 2016
Reactions of β-azolyl enamines and nitrile oxides were studied by both experimental and theoretical methods. (E)-β-(4-Nitroimidazol-5-yl), (5-nitroimidazol-4-yl) and isoxazol-5-yl enamines smoothly react regioselectively at room temperature in dioxane ...
Ilya V. Efimov, Marsel Z. Shafikov, Nikolai A. Beliaev, Natalia N. Volkova, Tetyana V. Beryozkina, Wim Dehaen, Zhijin Fan, Viktoria V. Grishko, Gert Lubec, Pavel A. Slepukhin, Vasiliy A. Bakulev   +10 more
doaj   +1 more source

Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition [PDF]

, 2016
International audienceGlycogen phosphorylase (GP) is a target for the treatment of hyperglycaemia in the context of type 2 diabetes. This enzyme is responsible for the depolymerization of glycogen into glucose thereby affecting the levels of glucose in ...
Azay-Milhau, Jacqueline, Balzarin, Sophie, Chajistamatiou, Aikaterini S., Chrysina, Evangelia D., Docsa, Tibor, Duret, Cédric, Gergely, Pál, Goyard, David, Kónya, Bálint, Leroy, Jérémy, Maurel, Patrick, Petit, Pierre, Praly, Jean-Pierre, Somsák, László, Tournier, Michel, Tousch, Didier, Vidal, Sébastien   +16 more
core   +2 more sources