Results 11 to 20 of about 4,771 (210)

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

Pharmaceuticals, 2023
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates.
Pan Xinhui
exaly   +3 more sources

A de-novo Approach Towards Divergent [3+2π/σ] Photocycloadditions of Nitrones via Assembly-Controlled Kinetic Electron Transfer Gating. [PDF]

Angew Chem Int Ed Engl
A metal‐free photocatalytic platform converts nitrones into 4‐isoxazolines and oxa–aza–bicycloheptanes through divergent [3+2π/σ] cycloadditions. Assembly‐controlled kinetic electron transfer gating dictates substrate activation, enabling selective reactivity beyond thermodynamic expectations.
Saha N, Kancherla R, Escorihuela J, Chandran S, Bera MK, Rueping M, König B.   +6 more
europepmc   +3 more sources

Synthesis of novel 1,2,4-oxadiazole-isoxazoline hybrids and their in silico potential with adenosine receptors [PDF]

Beilstein Journal of Organic Chemistry
A concise and efficient synthetic route to novel 1,2,4-oxadiazole-isoxazoline hybrids 7 has been developed via regioselective 1,3-dipolar cycloaddition of in situ-generated nitrile oxides with 3-(p-substituted-aryl)-5-vinyl-1,2,4-oxadiazoles 6.
Pshtiwan S. Mohammed, Mohammed K. S. Dalo, Onur C. Yazıcı, Muhammet Yildirim, Akın Sağırlı   +4 more
doaj   +2 more sources

Studies of the Synthesis of Fused Isoxazoline/Isoquinolinones and Evaluation of the Antifungal Activity of Isoxazole-like Benzamide and Isoquinolinone Hybrids [PDF]

Molecules
Isoxazole derivatives (isoxazoles, isoxazolines, and isoxazolidines) are present in the structure of several natural products and/or pharmaceutically interesting compounds.
Konstantinos A. Ouzounthanasis, Jasmina Glamočlija, Ana Ćirić, Alexandros E. Koumbis   +3 more
doaj   +2 more sources

The Chemoselective Reduction of Isoxazoline γ-Lactams Through Iminium Aza-Diels-Alder Reactions: A Short-Cut Synthesis of Aminols as Valuable Intermediates towards Nucleoside Derivatives

The Scientific World Journal, 2012
Isoxazoline γ-lactams are prepared starting from the regioisomeric cycloadducts of benzonitrile oxide to the N-alkyl 2-azanorbornenes taking advantage of the efficient catalytic oxidation by RuO4.
Misal Giuseppe Memeo, Mariella Mella, Paolo Quadrelli   +2 more
doaj   +2 more sources

A novel method for the determination of isoxazoline derivatives in plasma by ultra-high performance liquid chromatography–tandem mass spectrometry: validation and applicability to screening tests [PDF]

Journal of Veterinary Research
Isoxazoline derivatives such as fluralaner, sarolaner, lotilaner, and afoxolaner are a new class of insecticide and acaricide compounds. These compounds are characterised by rapid action and high efficacy over a period of up to several weeks.
Markowska-Buńka Paulina, Jaroszewski Jerzy J., Rasiński Bartosz, Ziółkowski Hubert   +3 more
doaj   +2 more sources

Evaluation of efficacy and pharmacokinetics of novel fluralaner tablet formulation (WellPet™) in dogs [PDF]

Frontiers in Veterinary Science
The increasing use of isoxazolines represents a major trend in the control of ectoparasites in companion animals. WellPet™ (Ourofino Saúde Animal Ltd., Brazil) is a newly developed, highly palatable oral tablet containing fluralaner.
Breno Cayeiro Cruz, Marina Belucci Teixeira, Marina Belucci Teixeira, Gessica Ariane de Melo Cruz, Juliana Aparecida do Carmo Emidio Moreira da Silva, Milenni Garcia Michels, Caroline Della Nina Pistoni, Marcus Antonio Martins Buso, Ferdinando Nielsen de Almeida, Igor Renan Honorato Gatto   +9 more
doaj   +2 more sources

A Facile Synthesis of Some Bioactive Isoxazoline Dicarboxylic Acids via Microwave-Assisted 1,3-Dipolar Cycloaddition Reaction

Reactions
The microwave-assisted 1,3-dipolar cycloaddition reaction of several aldoximes and dimethyl-2-methylene glutarate in the presence of diacetoxyiodobenzene as an oxidant produced four new isoxazoline-derived dimethyl carboxylates.
Jessica Master, Shekiel Sydney, Harsha Rajapaske, Malek Saffiddine, Vikiana Reyes, Richard W. Denton   +5 more
doaj   +2 more sources

Asymmetric Synthesis of Functionalized 2-Isoxazolines. [PDF]

ACS Omega
The asymmetric synthesis of the isoxazoline skeleton was achieved by the oxidation of hydroxylaminoalkyl furan prepared from simple starting materials: 2-methylfuran and (S)-epichlorohydrin. The synthesis features an NBS-mediated oxidation of hydroxylaminoalkyl furan to give an α,β-unsaturated ketone intermediate which cyclized to the isoxazoline.
Hamur B, Albayrak Halac F, Yilmazer F, Fleming FF, Kulu I, Altundas R.   +5 more
europepmc   +4 more sources

The mosquitocidal activity of isoxazoline derivatives afoxolaner, lotilaner, and fluralaner are not affected by mosquito sugar or antibiotic treatment [PDF]

Scientific Reports
Long-lasting insecticidal nets and indoor residual sprays have played a major role in significantly reducing the burden of malaria. However, the management of mosquitoes resistant to current insecticides continues to be challenging.
Harouna Soré, Wamdaogo Moussa Guelbeogo, Soumanaba Zongo, Judith M. Bolscher, Nicolas Ouédraogo, Adama Gansané, Teun Bousema, Katharine A. Collins, Koen J. Dechering   +8 more
doaj   +2 more sources