Results 11 to 20 of about 8,235 (246)

New (S)-verbenone-isoxazoline-1,3,4-thiadiazole hybrids: synthesis, anticancer activity and apoptosis-inducing effect

Future Medicinal Chemistry, 2023
Background: This study aimed to develop novel isoxazoline-1,3,4-thiadiazole hybrids from (S)-verbenone for potential anticancer treatment, particularly focusing on cytotoxic and apoptotic effects in hormonesensitive MCF-7 and triple-negative MDA-MB-231 ...
Mourad Fawzi (10304096), El Mostafa Ketatni (17065748), Aziz Auhmani (10304105), Abdellah N’ait Oussidi (17065747), Hamid Morjani (27104), Lahcen EL Ammari (15379430), Abdoullah Bimoussa (12809505), Ali Oubella (10304090), Mohamed Saadi (755383), Yassine Laamari (10304099), Moulay Youssef Ait Itto (15996891)   +10 more
core   +2 more sources

Discovery of a Novel Class of Acylthiourea-Containing Isoxazoline Insecticides against Plutella xylostella

Molecules, 2023
Isoxazoline structures are widely found in natural products and are rich in biological activities. This study discloses the development of a series of novel isoxazoline derivatives by introducing acylthiourea fragments to access insecticidal activity ...
Fangyi Li, Biaobiao Jiang, Yuqin Luo, Siqi He, Di Feng, Deyu Hu, Runjiang Song   +6 more
doaj   +2 more sources

Novel Quinazolinone–Isoxazoline Hybrids: Synthesis, Spectroscopic Characterization, and DFT Mechanistic Study

Chemistry, 2022
Quinazolinone and isoxazoline systems have attracted much attention due to their interesting pharmacological properties. The association of these two pharmacophores in a single hybrid structure can boost the biological activity or bring a new one ...
Yassine Rhazi, Mohammed Chalkha, Asmae Nakkabi, Imad Hammoudan, Mohamed Akhazzane, Mohamed Bakhouch, Samir Chtita, Mohamed El Yazidi   +7 more
doaj   +2 more sources

Biocatalytic Synthesis of Isoxazolines Enabled by Cryptic Nitrile Oxide Formation by a Vanadium-Dependent Chloroperoxidase. [PDF]

Angew Chem Int Ed Engl
The vanadium‐dependent haloperoxidase (VHPO) class of enzymes has been shown to catalyze cryptic nitrile oxide generation in an oxidative [3+2] cycloaddition reaction between aldoximes and alkenes to generate isoxazolines. This biotechnology has been applied to a chemoenzymatic sequence starting from aldehydes through in situ condensation with ...
Sharma M, Biegasiewicz KF.
europepmc   +3 more sources

Synthesis and biological activities of novel isoxazoline-linked pseudodisaccharide derivatives

Carbohydrate Research, 2012
A series of novel isoxazoline linked pseudodisaccharide derivatives were regiospecifically synthesized by 1,3-dipolar cycloaddition of alpha-allyl-C-glycopyranosides and sugar-derived nitrile oxides with good yields.
Pingzhu Zhang, Chao Wei, Jinchao Zhang   +2 more
exaly   +2 more sources

Selectivity of 3-bromo-isoxazoline inhibitors between human and Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenases

Bioorganic and Medicinal Chemistry, 2016
Compounds based on the 3-Br-isoxazoline scaffold fully inhibit glyceraldehyde 3-phosphate dehydrogenase from Plasmodium falciparum by selectively alkylating all four catalytic cysteines of the tetramer.
Stefano Bruno, Andrea Pinto, Gregorio Cullia   +2 more
exaly   +2 more sources

Functional Characterization of the Cat and Dog Wild-Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany. [PDF]

J Vet Pharmacol Ther
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Siegl L, Bethäuser M, Nürnberger D, Oswald S, Moritz A, Hamann M, Geyer J.   +6 more
europepmc   +2 more sources

Centripetal Axonal Transport as a Gateway to the CNS for Veterinary Antiparasitics: Bypassing the Blood-Brain Barrier, Clinical Impact in Vulnerable Age Groups, and the Potential Facilitating Role of PFAS. [PDF]

J Toxicol
The widespread use of veterinary antiparasitics, including neonicotinoids, isoxazolines, avermectins, and pyrethroids, is essential for canine health but raises concerns regarding potential neurotoxicity, particularly in young and geriatric animals.
Britti D, Marabelli R, Calzetta L.
europepmc   +2 more sources

Electrochemical Synthesis of Isoxazolines: Method and Mechanism [PDF]

Chemistry – A European Journal, 2022
Abstract An electrochemical method for the green and practical synthesis of a broad range of substituted isoxazoline cores is presented. Both aryl and more challenging alkyl aldoximes are converted to the desired isoxazoline in an electrochemically enabled regio‐ and diastereoselective reaction with electron‐deficient alkenes ...
Holman, Samuel D. L., Wills, Alfie G., Fazakerley, Neal J., Poole, Darren L., Coe, Diane M., Berlouis, Leonard, Reid, Marc   +6 more
openaire   +5 more sources

An easy access to chromano-isoxazolines and functionalized isoxazolines [PDF]

Arkivoc, 2004
2-Allyloxybenzaldoximes on treatment with ceric ammonium nitrate (CAN) at room temperature afforded 3a,4-dihydro-3H-chromeno[4,3-c]isoxazoles while benzaldoximes on interaction with Baylis-Hillman adduct in the presence of CAN produced functionalized isoxazolines.
Biswanath Das, Gurram Mahender, Harish Holla, Joydeep Banerjee   +3 more
openaire   +1 more source