Results 11 to 20 of about 2,967 (176)

Biocatalytic Synthesis of Isoxazolines Enabled by Cryptic Nitrile Oxide Formation by a Vanadium‐Dependent Chloroperoxidase [PDF]

Angewandte Chemie, Volume 138, Issue 20, 11 May 2026.
The vanadium‐dependent haloperoxidase (VHPO) class of enzymes has been shown to catalyze cryptic nitrile oxide generation in an oxidative [3+2] cycloaddition reaction between aldoximes and alkenes to generate isoxazolines. This biotechnology has been applied to a chemoenzymatic sequence starting from aldehydes through in situ condensation with ...
Manik Sharma, Kyle F. Biegasiewicz
wiley   +3 more sources

Functional Characterization of the Cat and Dog Wild‐Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany [PDF]

Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 3, Page 237-256, May 2026.
ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Lisa Siegl, Mies Bethäuser, Daniela Nürnberger, Stefan Oswald, Andreas Moritz, Melanie Hamann, Joachim Geyer   +6 more
wiley   +2 more sources

Studies of the Synthesis of Fused Isoxazoline/Isoquinolinones and Evaluation of the Antifungal Activity of Isoxazole-like Benzamide and Isoquinolinone Hybrids [PDF]

Molecules
Isoxazole derivatives (isoxazoles, isoxazolines, and isoxazolidines) are present in the structure of several natural products and/or pharmaceutically interesting compounds.
Konstantinos A. Ouzounthanasis, Jasmina Glamočlija, Ana Ćirić, Alexandros E. Koumbis   +3 more
doaj   +2 more sources

A novel method for the determination of isoxazoline derivatives in plasma by ultra-high performance liquid chromatography–tandem mass spectrometry: validation and applicability to screening tests [PDF]

Journal of Veterinary Research
Isoxazoline derivatives such as fluralaner, sarolaner, lotilaner, and afoxolaner are a new class of insecticide and acaricide compounds. These compounds are characterised by rapid action and high efficacy over a period of up to several weeks.
Markowska-Buńka Paulina, Jaroszewski Jerzy J., Rasiński Bartosz, Ziółkowski Hubert   +3 more
doaj   +2 more sources

Evaluation of efficacy and pharmacokinetics of novel fluralaner tablet formulation (WellPet™) in dogs [PDF]

Frontiers in Veterinary Science
The increasing use of isoxazolines represents a major trend in the control of ectoparasites in companion animals. WellPet™ (Ourofino Saúde Animal Ltd., Brazil) is a newly developed, highly palatable oral tablet containing fluralaner.
Breno Cayeiro Cruz, Marina Belucci Teixeira, Marina Belucci Teixeira, Gessica Ariane de Melo Cruz, Juliana Aparecida do Carmo Emidio Moreira da Silva, Milenni Garcia Michels, Caroline Della Nina Pistoni, Marcus Antonio Martins Buso, Ferdinando Nielsen de Almeida, Igor Renan Honorato Gatto   +9 more
doaj   +2 more sources

Asymmetric Synthesis of Functionalized 2-Isoxazolines [PDF]

ACS Omega
The asymmetric synthesis of the isoxazoline skeleton was achieved by the oxidation of hydroxylaminoalkyl furan prepared from simple starting materials: 2-methylfuran and (S)-epichlorohydrin. The synthesis features an NBS-mediated oxidation of hydroxylaminoalkyl furan to give an α,β-unsaturated ketone intermediate which cyclized to the isoxazoline.
Beyza Hamur, Fatma Albayrak Halac, Fethiye Yilmazer, Fraser F. Fleming, Irem Kulu, Ramazan Altundas   +5 more
openaire   +4 more sources

The mosquitocidal activity of isoxazoline derivatives afoxolaner, lotilaner, and fluralaner are not affected by mosquito sugar or antibiotic treatment [PDF]

Scientific Reports
Long-lasting insecticidal nets and indoor residual sprays have played a major role in significantly reducing the burden of malaria. However, the management of mosquitoes resistant to current insecticides continues to be challenging.
Harouna Soré, Wamdaogo Moussa Guelbeogo, Soumanaba Zongo, Judith M. Bolscher, Nicolas Ouédraogo, Adama Gansané, Teun Bousema, Katharine A. Collins, Koen J. Dechering   +8 more
doaj   +3 more sources

4′-Methyl-3-(4-nitrophenyl)-4-phenyl-4,5,1′,2′,3′,4′-hexahydrospiro[isoxazole-5,2′-naphthalen]-1′-one

Acta Crystallographica Section E, 2008
The title compound, C25H20N2O4, is a new spiro-isoxazoline derivative. It contains a five-membered isoxazoline ring (A), a tetralone unit (E and D), a 4-nitrophenyl substituent (B), and a phenyl ring (C).
Helen Stoeckli-Evans, Taibi Ben Hadda, Brahim Bennani, Najib Ben Larbi, Abdelali Kerbal, Ghali Alhouari   +5 more
doaj   +1 more source

Hypervalent iodine-mediated Ritter-type amidation of terminal alkenes: The synthesis of isoxazoline and pyrazoline cores

Beilstein Journal of Organic Chemistry, 2018
Hypervalent iodine-mediated olefin functionalization provides a rapid gateway towards accessing both various heterocyclic cores and functional groups.
Sang Won Park, Soong-Hyun Kim, Jaeyoung Song, Ga Young Park, Darong Kim, Tae-Gyu Nam, Ki Bum Hong   +6 more
doaj   +1 more source

Enantioselective 5-exo-Fluorocyclization of Ene-Oximes

Molecules, 2019
The enantioselective 5-exo-fluorocyclization of ene-oxime compounds was demonstrated under phase-transfer catalysis. Although deprotonative fluorinations competed, the chemical yields and the ee values of the desired isoxazoline products were generally ...
Taiki Rouno, Tomoki Niwa, Kousuke Nishibashi, Nobuharu Yamamoto, Hiromichi Egami, Yoshitaka Hamashima   +5 more
doaj   +1 more source